DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5707 and Ephx2

DIOPT Version :9

Sequence 1:	NP_001246563.1	Gene:	CG5707 / 48422	FlyBaseID:	FBgn0026593	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_075225.1	Gene:	Ephx2 / 65030	RGDID:	620732	Length:	554	Species:	Rattus norvegicus

Alignment Length:	219	Identity:	48/219 - (21%)
Similarity:	82/219 - (37%)	Gaps:	57/219 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DMPWGYVVGKWYGNRQVRP--------------ILALHGWLDNLGTWDKLLPLLPK-HLGVLCID 78
            |:..|||.        |:|              |...||:.::..:|...:|.|.: ...||.||
  Rat   234 DVSHGYVT--------VKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAID 290

  Fly    79 LPGHGYSSKLPEGIAYHFVDYLC-VILRVMEEYRWQKVSLMAHSMSAMLCFVFASLYPHRTDMLV 142
            :.|:|.||..|| |..:.::.|| .::..:.:....:...:.|..:.:|.:..|..:|.|...:.
  Rat   291 MKGYGDSSSPPE-IEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVA 354

  Fly   143 SIDIVKTRYRKPPSQIDYLRKNIEGYIVEDERFANSKRQEPPAYTYTEMEQVLYKGTDYSVELEN 207
            |::..........|.::.:|                   ..|.:.|.     ||.......|.|
  Rat   355 SLNTPLMPPNPEVSPMEVIR-------------------SIPVFNYQ-----LYFQEPGVAEAE- 394

  Fly   208 CRHILERNISRSTKFPAKFFFSRD 231
                ||:|:||:.|   .||.:.|
  Rat   395 ----LEKNMSRTFK---SFFRTSD 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5707	NP_001246563.1	MhpC	46..318	CDD:223669	43/202 (21%)
Ephx2	NP_075225.1	Phosphatase	1..224
		HAD-SF-IA-v3	5..203	CDD:273662
		Phosphate binding. /evidence=ECO:0000250\|UniProtKB:P34913	123..124
		HAD_like	<142..205	CDD:304363
		Epoxide hydrolase	233..554		48/219 (22%)
		Abhydrolase	239..>379	CDD:304388	32/167 (19%)
		Abhydrolase_1	257..530	CDD:278959	42/188 (22%)
		Microbody targeting signal. /evidence=ECO:0000255	552..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335868
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840