DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5707 and EPHX2

DIOPT Version :9

Sequence 1:	NP_001246563.1	Gene:	CG5707 / 48422	FlyBaseID:	FBgn0026593	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001970.2	Gene:	EPHX2 / 2053	HGNCID:	3402	Length:	555	Species:	Homo sapiens

Alignment Length:	205	Identity:	49/205 - (23%)
Similarity:	82/205 - (40%)	Gaps:	46/205 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DMPWGYVVGKWYGNRQVR---------PILAL-HGWLDNLGTWDKLLPLLPK-HLGVLCIDLPGH 82
            ||..|||..|    .:||         |.:.| ||:.::..:|...:|.|.: ...||.:|:.|:
Human   236 DMSHGYVTVK----PRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGY 296

  Fly    83 GYSSKLPEGIAYHFVDYLC-VILRVMEEYRWQKVSLMAHSMSAMLCFVFASLYPHRTDMLVSIDI 146
            |.||..|| |..:.::.|| .::..:::....:...:.|....||.:..|..||.|...:.|::.
Human   297 GESSAPPE-IEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360

  Fly   147 VKTRYRKPPSQIDYLRKNIEGYIVEDERFANSKRQEPPAYTYTEMEQVLYKGTDYSVELENCRHI 211
            .........|.::.::.|                   |.:.|.     ||.......|.|
Human   361 PFIPANPNMSPLESIKAN-------------------PVFDYQ-----LYFQEPGVAEAE----- 396

  Fly   212 LERNISRSTK 221
            ||:|:||:.|
Human   397 LEQNLSRTFK 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5707	NP_001246563.1	MhpC	46..318	CDD:223669	42/188 (22%)
EPHX2	NP_001970.2	Phosphatase	1..224
		HAD_sEH-N_like	3..214	CDD:319790
		Phosphate binding. /evidence=ECO:0000269\|PubMed:15096040	123..124
		Epoxide hydrolase	235..555		49/205 (24%)
		Abhydrolase_1	259..531	CDD:395444	41/178 (23%)
		Microbody targeting signal. /evidence=ECO:0000255	553..555
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142142
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840