DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3558 and Fhip1b

DIOPT Version :9

Sequence 1:	NP_001137777.1	Gene:	CG3558 / 48421	FlyBaseID:	FBgn0025681	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_001229293.1	Gene:	Fhip1b / 74349	MGIID:	1921599	Length:	989	Species:	Mus musculus

Alignment Length:	1134	Identity:	325/1134 - (28%)
Similarity:	474/1134 - (41%)	Gaps:	293/1134 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GH---VGPLRQRPIDAATDCDPRACYDSFCKHWQQAFEIIQHSAPPS----HDDVLGVVSHLDYM 72
            ||   .|...|.|:.|    ||..|...|..||.|...|::...|.:    .||:..|.:|...|
Mouse    16 GHRVPQGASLQTPVMA----DPETCLMVFKNHWSQVVRILERQGPRAATGGADDLSAVRNHTYQM 76

  Fly    73 VTLLLVELHHCNKVSLPAAEASGPPAAPCLEFLLSENLLDKLYEWACTTGRYANAV---RLEQLK 134
            :|||..:.      ::|:| .|||  .|.|||.|.|:||.::..|......:.:.|   |.||||
Mouse    77 LTLLAEDR------AVPSA-PSGP--GPLLEFALREDLLSRVLTWQLQWDEFGDGVEERRAEQLK 132

  Fly   135 LYELLVSHSRHQLLCHEPFLRPLLKILASSQGEIFP--PDLEKRLVILLNQLCVVLMQNVHLLDL 197
            |:|:|||.:|..||.|.|....||.:| .:.|...|  |.|::.||:||:||||.:.:...||:.
Mouse   133 LFEMLVSEARQPLLRHGPVREALLALL-DACGRPVPSSPALDEGLVLLLSQLCVCVAREPSLLEF 196

  Fly   198 FFFSAQTQVQEQILNGNVAPPKSGTTTNFIIFSLLIPYVHREGSLGHQARDALLLCMALSQKNSN 262
            |.               ..||:.|.....::||.|:|:|||||:||.||||||||.||||..:..
Mouse   197 FL---------------QPPPEPGAAPRLLLFSRLVPFVHREGTLGQQARDALLLLMALSDGSPT 246

  Fly   263 IGTYIAQYSSICPLLVTGLGGLYSRLPNSIEISSIDWHRITPDDVTEIPELTLFMNALEFCNAVV 327
            :|.|||.:|..||:|.|||..|||.||..||:...|||.:..:|...:|.|.|||::|||||||:
Mouse   247 VGRYIADHSYFCPVLATGLSALYSSLPRKIEVPGDDWHCLRREDWIGVPALALFMSSLEFCNAVI 311

  Fly   328 QVAHEMIKQQLLDFMYQGFIVPVLGPAILQTLKGKHFQTNIDSQISAMSYLDLILRSITEPGLLR 392
            ||||.::::||:|:::.||:|||:|||:        .:|:::..|::.:||:|.||||:||.|||
Mouse   312 QVAHPLVQKQLVDYIHNGFLVPVMGPAL--------HKTSVEEMIASTAYLELFLRSISEPALLR 368

  Fly   393 AFVRFLLDTEKFDGERILDALVERLNSPDANLCMVTMALFDTLLGLHCEDLMLELLLKFMLPGKH 457
            .|:|||| ..:.|...|||.||.|:.| ::.||||:::||.|||.|.|||::|:|:|::::|..|
Mouse   369 TFLRFLL-LHRHDTHTILDTLVARIGS-NSRLCMVSLSLFRTLLNLSCEDVLLQLVLRYLVPCNH 431

  Fly   458 VPISHRHKINKIDPYLNSSEFFLELSPDVMK------------------------RARDLARPKS 498
            |.:|.:..:..:|.|..:::.||.|.|...:                        |..|:..|.|
Mouse   432 VMLSQKPAVRDVDLYGRAADKFLSLIPRCCRHHAPSPPRPEHASWARGGPSREAGRREDITGPGS 496

  Fly   499 VHEPVVSELT-PLPSLPSP----VMSKTIGANWNYYGVHTGDSLYA------------------- 539
            ......|.:| |.||.||.    :..:::|.:.:...|.....|.|
Mouse   497 PSVDSSSVVTVPRPSTPSRLALFLRQQSLGGSESPGPVPRSPGLTASPTSSPSRRPSPAEEPGEL 561

  Fly   540 --NIQAYLFEAHWRIAQCQKDCLKWANSYRYQKWPRHGQ---GRVHAHAL--ELARQFFSEFGGG 597
              |...||.||...:.:|.:.|..|:..|..::.|....   .|....:|  |..|.
Mouse   562 EDNYLEYLREARRGVDRCVRACRTWSAPYDGERPPPEPNPLGSRTKKRSLLPEEDRD-------- 618

  Fly   598 PIAANETGEKQLDS---LQSIGESSGY--------------ESFK-------WRPADEESEATDT 638
              ...|..|:.|.|   ...:|::.||              |..|       ..|.:...|..:.
Mouse   619 --NVREGEEENLGSRGLAVGVGDTPGYLLPPQLNGVPGPWPEGAKKVRLVPRLVPQEGVRELLEG 681

  Fly   639 TVATTASEADMDHNSSSLSSVL--GASGKR---------------ESWRTSNSNRNELILTDLDF 686
            |....|...........|...|  |.:|..               ||:..........:.:.|..
Mouse   682 TSEDMAGLESFGQELQELEVALSNGGAGSEPPLEPPLPPEEEEAYESFTCPPEPPGPFLSSPLRT 746

  Fly   687 SEDLFAQGTVSLGPFLNAIWGKLQTFTSNSLYVNLHLTGLITRLAWYPLPLIHSLLLRSDIAITS 751
            ...|.:|...  |||:..::.||:....||:|||..||||:.:||.:|.||:.|.||.:::....
Mouse   747 LHQLPSQPFT--GPFMAVLFAKLENMLQNSVYVNFLLTGLVAQLACHPQPLLRSFLLNTNMVFQP 809

  Fly   752 DTPSFHQVLRILKQQIDAELPVTEDSLEIIDVARSSLIDREFRLANARKGNEGSPMHHSQQQQMV 816
            ...|..|||..:|.:|::.....||...::..|:..||.|
Mouse   810 SVKSLLQVLGSVKNKIESFAASQEDFPALLSKAKKYLIAR------------------------- 849

  Fly   817 TNSGQQQGQLRSAYATLSAATPVQATPTSAYDPFKRSDNKRRSISKSITSMFSRKSASTSTAPPN 881
                   |:|..|..           ||:...| :|||:..||...|:..:..|.:.|    |..
Mouse   850 -------GKLDWAEG-----------PTAGPAP-RRSDSLVRSRRPSLGELLLRHAHS----PTR 891

  Fly   882 GSSASSGLSQIYAFFTGAASNLVGNNASNDGRGISQAQTSAGTCETSLSTQPPAGASRTGANATS 946
            ...|...|                 ....||.|:.                  .|....||:...
Mouse   892 ARQAVQVL-----------------QPGRDGTGLG------------------LGGGSPGASTPV 921

  Fly   947 TAASGSNSSIAGSTLTLSAQSNTTTHSASTLHGLDGGPSTGGFNSEPASLDSVASMGIIASTSGT 1011
            ....|..|...|..|
Mouse   922 LLPRGGASERQGEAL-------------------------------------------------- 936

  Fly  1012 ERSRDLALCAVLMDEWLKELAAIAQEQSV 1040
             |.::...|||:..|:|||||||:|..:|
Mouse   937 -RVKNAVYCAVIFPEFLKELAAISQAHAV 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3558	NP_001137777.1	RAI16-like	101..452	CDD:287259	160/355 (45%)
CG3558	NP_001137777.1	LbR-like	898..979	CDD:248061	10/80 (13%)
Fhip1b	NP_001229293.1	RAI16-like	97..426	CDD:370927	160/354 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..562		4/36 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..635		10/57 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..731		4/26 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842620
Domainoid	1	1.000	314	1.000	Domainoid score	I1290
eggNOG	1	0.900	-	-		E1_KOG3695
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1529
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141539at2759
OrthoFinder	1	1.000	-	-		FOG0003063
OrthoInspector	1	1.000	-	-		otm44264
orthoMCL	1	0.900	-	-		OOG6_105010
Panther	1	1.100	-	-	LDO	PTHR21705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4805
SonicParanoid	1	1.000	-	-		X2039
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.830