DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3558 and Fhip1a

DIOPT Version :9

Sequence 1:	NP_001137777.1	Gene:	CG3558 / 48421	FlyBaseID:	FBgn0025681	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	XP_038958681.1	Gene:	Fhip1a / 365834	RGDID:	1565007	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	1076	Identity:	306/1076 - (28%)
Similarity:	455/1076 - (42%)	Gaps:	324/1076 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DPRACYDSFCKHWQQAFEIIQH------------SAPPSHDDVLGVVSHLDYMVTLLLVELHHCN 84
            ||..|...|..||.|..:|::.            |.||  |:...|.:::::|:.||:.|
  Rat    21 DPETCMIVFKNHWAQVVKILEKHDPLKNIQAKYGSIPP--DEASAVQNYVEHMLFLLIEE----- 78

  Fly    85 KVSLPAAEASGPPAAPCLEFLLSENLLDKLYEWACTTGRYANAVRLEQLKLYELLVSHSRHQLLC 149
                   :|......|.|||::.||:::||:.|:... .:.:..:|||||:||:||:.|...||.
  Rat    79 -------QAKDAAMGPILEFVVCENIMEKLFLWSLRR-EFTDETKLEQLKMYEMLVTQSYQPLLH 135

  Fly   150 HEPFLRPLLKILASSQGEIFPPDLEKRLVILLNQLCVVLMQNVHLLDLFFFSAQTQVQEQILNGN 214
            |:|.|:||:.:|:|..|.. .|.:|.:||:||||||.:|.::..:|:|||.:::.|
  Rat   136 HKPILKPLMMLLSSCSGTA-TPAVEGKLVVLLNQLCSILAKDPSILELFFHTSEDQ--------- 190

  Fly   215 VAPPKSGTTTNFIIFSLLIPYVHREGSLGHQARDALLLCMALSQKNSNIGTYIAQYSSICPLLVT 279
                   ...||:|||||||::||||::|.|||||||..|:||.:||.:..:|.:.:..||:|.|
  Rat   191 -------GAANFLIFSLLIPFIHREGTVGQQARDALLFIMSLSAENSMVANHIVENTYFCPVLAT 248

  Fly   280 GLGGLYSRLPNSIEISSIDWHRITPDDVTEIPELTLFMNALEFCNAVVQVAHEMIKQQLLDFMYQ 344
            ||.||||.||..:|....:||.:..||...:|.|..|||:|||||||:||||.:|:.||:.::|.
  Rat   249 GLSGLYSSLPTKLEEKGEEWHCLLKDDWLLLPALVQFMNSLEFCNAVIQVAHPLIRTQLVSYIYN 313

  Fly   345 GFIVPVLGPAILQTLKGKHFQTNIDSQISAMSYLDLILRSITEPGLLRAFVRFLLDTEKFDGERI 409
            ||:||||.||:        .:..::..::..:||||.||||:||.||..|:||:| ..:.:...|
  Rat   314 GFLVPVLAPAL--------HKVTVEEVMTTTAYLDLFLRSISEPALLEIFLRFIL-LHQHENVHI 369

  Fly   410 LDALVERLNSPDANLCMVTMALFDTLLGLHCEDLMLELLLKFMLPGKHVPISHRHKINKIDPYLN 474
            ||.|..|:|:| ..||:|::|||.||:||||||:||:|:|::::|..|:.:|.|..:.:.|.|..
  Rat   370 LDTLTSRINTP-FRLCVVSLALFRTLIGLHCEDVMLQLVLRYLVPCNHMMLSQRWAVKERDCYSV 433

  Fly   475 SSEFFLELSP---------DVMKRARD-LARPKSVHEPVVSELTPLPSL----------PSPVMS 519
            |:...|.|:|         .:..:.|| :...|.:|:....|..|||..          |.|..:
  Rat   434 SAAKLLALTPVCCASGITLTLGNQERDYILWSKCMHDGSGPEEQPLPETPCSPSSPPPPPQPAPA 498

  Fly   520 KTIGANWNYYGVHTGDSLYANIQAYLFEAHWRIAQCQKDCLKWANSY------------------ 566
            ..|        |..|.:|..:...||:|||..|..|.:||..|:..|
  Rat   499 ACI--------VEYGKALDISYLQYLWEAHTNILHCMRDCRVWSALYDGDSPDPETFLQSLSEES 555

  Fly   567 ------------------------RYQ---KW--------------------------------- 571
                                    :.|   :|
  Rat   556 RENSSHPEARLSQQCIRTSGQTKDKSQSELEWDDSYDTGISSGADVGSPGPYDDVETPAPPAPID 620

  Fly   572 -PRHGQGRVHAHALELARQFFSE------------------------------------------ 593
             |:|.| .:..:|:.|.:..:.|
  Rat   621 PPKHIQ-EMKKNAILLFKGSYIEESDFQDDVMVYRLCAEKDAEDTREPQGATTDPPAEAQPKAQP 684

  Fly   594 ------------FGGGPIAANETGEKQLDSLQSIGESSGYESFKWRPADEESEAT---------- 636
                        |...|.|.::.|.:..|..|::...:..||......|.:||.|
  Rat   685 EAQSLPTSNGPLFSPNPEAESKPGRESSDLCQNMFSEAKPESEPGVALDSDSELTVPTFEAEPQS 749

  Fly   637 DTTVATTASE---ADMDHNSSSLSSVLGASGKRE---------------SWRTSNSNRNELILTD 683
            |:.||:|..|   |..|.....|.|  |..|..|               ..||......|....|
  Rat   750 DSPVASTEGEDFIAQYDQIIQELDS--GTEGLTEQSVPASEPSLLTHADEGRTECKAEEEEEDDD 812

  Fly   684 LD-----------------FSEDLF---------AQGTVSLGPFLNAIWGKLQTFTSNSLYVNLH 722
            .|                 ..||..         .|||...||||:.:..||:....|||:|||.
  Rat   813 FDSLMADTPAEEAAPSPFGVGEDTATFTSRHPTRTQGTPFTGPFLSVVLSKLENMLENSLHVNLL 877

  Fly   723 LTGLITRLAWYPLPLIHSLLLRSDIAITSDTPSFHQVLRILKQQIDAELPVTEDSLEIIDVARSS 787
            |.|:||:||.||.||:.|.||.:::.......|.:|||..:|.:|:....|..|...::..|:..
  Rat   878 LIGIITQLASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDFPGLLIQAQQY 942

  Fly   788 LIDREFRLANARKGNEGSPMHHSQQQQMVTNSGQQQGQLRSAYATLSAATPVQATPTSAYDPFKR 852
            |:   ||:                                    .:|..|||..|.    ||.:
  Rat   943 LL---FRV------------------------------------DMSDMTPVALTK----DPIQ- 963

  Fly   853 SDNKRRSISKSIT-------SMFSRKSASTSTAPPN 881
             :..|....|::|       ..|....|..:.||||
  Rat   964 -EISRPESDKTLTDGPPRVLQPFLGNRAQMTKAPPN 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3558	NP_001137777.1	RAI16-like	101..452	CDD:287259	157/350 (45%)
CG3558	NP_001137777.1	LbR-like	898..979	CDD:248061
Fhip1a	XP_038958681.1	RAI16-like	88..411	CDD:370927	157/350 (45%)
Fhip1a	XP_038958681.1	MSCRAMM_ClfB	<660..>766	CDD:411414	18/105 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141539at2759
OrthoFinder	1	1.000	-	-		FOG0003063
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105010
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2039
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820