DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3558 and Fhip2b

DIOPT Version :9

Sequence 1:	NP_001137777.1	Gene:	CG3558 / 48421	FlyBaseID:	FBgn0025681	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_001163945.1	Gene:	Fhip2b / 306015	RGDID:	1308870	Length:	744	Species:	Rattus norvegicus

Alignment Length:	856	Identity:	164/856 - (19%)
Similarity:	291/856 - (33%)	Gaps:	258/856 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VGHVGPLRQRPIDAATDCDPRA-CYDSFCKHWQ----QAFEIIQHSAPPSHDDVLGVVSHLDYMV 73
            :..:|.|.|..:.|.   :|.. ...:|.:||:    ...|....:.|....|   :...|..|:
  Rat     2 LSRLGALLQEAVGAR---EPSIDLLQAFVEHWKGITHYYIESTDENTPAKKTD---IPWRLKQML 60

  Fly    74 TLLLVELHHCNKVSLPAAEASGPPAAPCLEFLLSENLLDKLYEWACTTGR--YANAVRLEQLKLY 136
            .:|:.|         ...:||...|.||||:||...:|:.|    ||.|:  |...:|.:..:.:
  Rat    61 DILVYE---------EKQQASSGEAGPCLEYLLQHKILETL----CTLGKAEYPPGMRQQVFQFF 112

  Fly   137 ELLVSHSRHQLLCHEPFLRPLLKILASSQGEIFPPDL-EKRLVILLNQLCVVLMQNVHLLDLFFF 200
            ..:::..:|.||.:....||:.|:|  ..|...|..| ||..|...:.||..:.|:..||.....
  Rat   113 SKVLAQVQHPLLHYLSVHRPVQKLL--RLGGTAPGSLTEKEEVQFTSVLCSKIQQDPELLAYILE 175

  Fly   201 SAQTQVQEQILNGNVAPPK--------------------------------------------SG 221
            ..:...:::...|:.||||                                            ||
  Rat   176 GKKMIGKKKTARGSAAPPKDIAGYRDKDCPHSDAPSGDPGLDKEYHGVPALSVHLPAVTEGPESG 240

  Fly   222 TTTNFIIFSLLIPYVHREGSLGHQARDALLLCMALSQKNSNIGTYIAQYSSICPLLVTGLGGLYS 286
            ...:.:|.|||.....::..|..:|::.:||.::|:...:  .||:.|.:|.|..:...|..||.
  Rat   241 PGESNLITSLLGLCKSKKSRLALKAQENILLLVSLASPAA--ATYLTQSTSCCTAIAEHLCQLYR 303

  Fly   287 RLPNSIE------ISSIDWHRI--TPDDVTEIP---ELTLFMNALEFCNAVVQVAHEMIKQQLLD 340
            .:|..::      :..|.| |:  .|.|.|..|   .|..|:...::|:.::..||.::...|..
  Rat   304 SMPACLDPADIATLEGISW-RLPSAPSDETAFPGKEALAAFLGWFDYCDHLITEAHTVVADALAR 367

  Fly   341 FMYQGFIVPVLGPAILQTLKGKHFQTNIDSQISAMSYLDLILRSITEPGLLRAFVRFLLDTE--- 402
            .:.:...|..|.|.:|...:        .|.:::.:.|.::||.:..|.||:..:.|||.|:
  Rat   368 AVAEKLFVETLQPQLLHVSE--------QSILTSTALLTVLLRQLRSPALLQEAMTFLLGTDQQP 424

  Fly   403 --KFDGERILDA-LVERLNSPDANLCMVTMALFDTLLGLHCEDLMLELLLK------FMLPGKHV 458
              |.|....|.. |:...:.....:.:.|:.||:.||....|..:..|:|:      ::..|...
  Rat   425 ASKEDSSHTLGTHLIMHCDHLSDEISIATLRLFEELLQKPHERAIRSLVLQNLEGRLYVARGSPE 489

  Fly   459 PISHRHKIN-KIDPYLNSSEFFLELSPDVMKRARDLARPKSVHEPVVSELTPLPSLPSPVMSKTI 522
            |.|:...:: :.|||.  ::.||:.......:........|..:..|:|:........|..:||
  Rat   490 PESYEDNLDLEEDPYF--TDGFLDSGLQPSTKPPPAPATSSDGKTAVTEIVNSFLCLVPEEAKT- 551

  Fly   523 GANWNYYGVHTGDSLYANIQAYLFEAHWRIAQCQKDCLKWANSYRYQKWPRHGQGRVHAHALELA 587
            .|.....|..|          |:.:|:....:|......|.       ||
  Rat   552 SAFLEENGYDT----------YVHDAYGLFQECSSRVAHWG-------WP--------------- 584

  Fly   588 RQFFSEFGGGPIAANETGEKQLDSLQSIGESSGYESFKWRPADEESEATDTTVATTASEADMDHN 652
                  .|..|:.::|..                     ||..|
  Rat   585 ------LGPAPLDSHEPE---------------------RPFFE--------------------- 601

  Fly   653 SSSLSSVLGASGKRESWRTSNSNRNELILTDLDFSEDLFAQGTVSLGPFLNAIWGKLQTFTSNSL 717
                                                          |.||..::.::........
  Rat   602 ----------------------------------------------GRFLQVLFDRIARILDQPY 620

  Fly   718 YVNLHLTGLITRLAWYPLPLIHSLLLRSDIAIT---------------------SDTPSFHQVLR 761
            .:||.:|.:::|||.:|.|.||..||...|::.                     ...|.|...|.
  Rat   621 SLNLQVTSVLSRLALFPHPHIHEYLLDPYISLAPGCRSLFSVLVRVIGDLMQRIQRVPQFSGKLL 685

  Fly   762 ILKQQIDAELP 772
            ::::|:..::|
  Rat   686 LVRKQLMGQIP 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3558	NP_001137777.1	RAI16-like	101..452	CDD:287259	95/420 (23%)
CG3558	NP_001137777.1	LbR-like	898..979	CDD:248061
Fhip2b	NP_001163945.1	RAI16-like	79..477	CDD:287259	95/414 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3695
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.700