DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3558 and Fhip1b

DIOPT Version :9

Sequence 1:	NP_001137777.1	Gene:	CG3558 / 48421	FlyBaseID:	FBgn0025681	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_001005538.2	Gene:	Fhip1b / 293343	RGDID:	1359585	Length:	989	Species:	Rattus norvegicus

Alignment Length:	1136	Identity:	325/1136 - (28%)
Similarity:	478/1136 - (42%)	Gaps:	297/1136 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GH---VGPLRQRPIDAATDCDPRACYDSFCKHWQQAFEIIQ----HSAPPSHDDVLGVVSHLDYM 72
            ||   .|...|.|:.|    ||..|...|..||.|...|::    .:|....||:..|.:|...|
  Rat    16 GHRVPQGASLQTPVMA----DPETCLMVFKNHWSQVVRILERQGSRAAAGGADDLSAVRNHTYQM 76

  Fly    73 VTLLLVELHHCNKVSLPAAEASGPPAAPCLEFLLSENLLDKLYEWACTTGRYANAV---RLEQLK 134
            :|||..:.      ::|:| .|||  .|.|||.|.|:||.::..|......:.:.|   |.||||
  Rat    77 LTLLAEDR------AVPSA-PSGP--GPLLEFALREDLLSRVLTWQLQWDEFGDGVEERRAEQLK 132

  Fly   135 LYELLVSHSRHQLLCHEPFLRPLLKILASSQGEIFP--PDLEKRLVILLNQLCVVLMQNVHLLDL 197
            |:|:|||.:|..||.|.|....||.:| .:.|...|  |.|::.||:||:||||.:.:...||:.
  Rat   133 LFEMLVSEARQPLLRHGPVREALLALL-DACGRPVPSSPALDEGLVLLLSQLCVCVAREPSLLEF 196

  Fly   198 FFFSAQTQVQEQILNGNVAPPKSGTTTNFIIFSLLIPYVHREGSLGHQARDALLLCMALSQKNSN 262
            |.               ..||:.|.....::||.|:|:|||||:||.||||||||.||||..:..
  Rat   197 FL---------------QPPPEPGAAPRLLLFSRLVPFVHREGTLGQQARDALLLLMALSDGSPT 246

  Fly   263 IGTYIAQYSSICPLLVTGLGGLYSRLPNSIEISSIDWHRITPDDVTEIPELTLFMNALEFCNAVV 327
            :|.|||.:|..||:|.|||..|||.||..||:...|||.:..:|...:|.|.|||::|||||||:
  Rat   247 VGRYIADHSYFCPVLATGLSALYSSLPRKIEVPGDDWHCLRREDWIGVPALALFMSSLEFCNAVI 311

  Fly   328 QVAHEMIKQQLLDFMYQGFIVPVLGPAILQTLKGKHFQTNIDSQISAMSYLDLILRSITEPGLLR 392
            ||||.::::||:|:::.||:|||:|||:        .:|:::..|::.:||:|.||||:||.|||
  Rat   312 QVAHPLVQKQLVDYIHNGFLVPVMGPAL--------HKTSVEEMIASTAYLELFLRSISEPALLR 368

  Fly   393 AFVRFLLDTEKFDGERILDALVERLNSPDANLCMVTMALFDTLLGLHCEDLMLELLLKFMLPGKH 457
            .|:|||| ..:.|...|||.||.|:.| ::.||||:::||.|||.|.|||::|:|:|::::|..|
  Rat   369 TFLRFLL-LHRHDTHTILDTLVARIGS-NSRLCMVSLSLFRTLLNLSCEDVLLQLVLRYLVPCNH 431

  Fly   458 VPISHRHKINKIDPYLNSSEFFLELSPDVMK------------------------RARDLARPKS 498
            |.:|.:..:..:|.|..:::.||.|.|...:                        |..|:..|.|
  Rat   432 VMLSQKPAVRDVDLYGRAADKFLSLIPRCCRHHAPSPPRPEHASWARGGPSREPGRREDITGPGS 496

  Fly   499 VHEPVVSELT-PLPSLPSP----VMSKTIGANWNYYGVHTGDSLYA------------------- 539
            ......|.:| |.||.||.    :..:::|.:.:.........|.|
  Rat   497 PSVDSSSVVTVPRPSTPSRLALFLRQQSLGGSESPGPAPRSPGLTASPTSSPGRRPSPAEEPGEL 561

  Fly   540 --NIQAYLFEAHWRIAQCQKDCLKWANSYRYQKWPRHGQ---GRVHAHAL--ELARQFFSEFGGG 597
              |...||.||...:.:|.:.|..|:..|..::.|....   .|....:|  |..|.
  Rat   562 EDNYLEYLREARRGVDRCVRACRTWSAPYDGERPPPEPNPLGSRTKKRSLLPEEDRD-------- 618

  Fly   598 PIAANETGEKQLDS---LQSIGESSGY--------------ESFKW-----RPADEES-----EA 635
              ...|..|:.|.|   ...:|::.||              |..|.     |...:|.     |.
  Rat   619 --NVREGEEENLGSRGLAVGVGDTPGYLPPPQLNGVPGPWPEGAKKVRLVPRLVSQEGVRELLEG 681

  Fly   636 TDTTVATTAS-EADMDHNSSSLSSVLGASGKR---------------ESWRTSNSNRNELILTDL 684
            |...:|...| ..::.....:||:  |.:|..               ||:..........:.:.|
  Rat   682 TSEGMAGLESFGQELQELEVALSN--GGAGSEPPLEPPLPPEEEEAYESFTCPPEPPGPFLSSPL 744

  Fly   685 DFSEDLFAQGTVSLGPFLNAIWGKLQTFTSNSLYVNLHLTGLITRLAWYPLPLIHSLLLRSDIAI 749
            .....|.:|...  |||:..::.||:....||:|||..||||:.:||.:|.||:.|.||.:::..
  Rat   745 RTLHQLPSQPFT--GPFMAVLFAKLENMLQNSVYVNFLLTGLVAQLACHPQPLLRSFLLNTNMVF 807

  Fly   750 TSDTPSFHQVLRILKQQIDAELPVTEDSLEIIDVARSSLIDREFRLANARKGNEGSPMHHSQQQQ 814
            .....|..|||..:|.:|::.....||...::..|:..||.|
  Rat   808 QPSVKSLLQVLGSVKNKIESFAASQEDFPALLSKAKKYLIAR----------------------- 849

  Fly   815 MVTNSGQQQGQLRSAYATLSAATPVQATPTSAYDPFKRSDNKRRSISKSITSMFSRKSASTSTAP 879
                     |:|..|....:..||            :|||:..||...|:..:..|.:.|    |
  Rat   850 ---------GKLDWAEGPTAGPTP------------RRSDSLVRSRRPSLGELLLRHAHS----P 889

  Fly   880 PNGSSASSGLSQIYAFFTGAASNLVGNNASNDGRGISQAQTSAGTCETSLSTQPPAGASRTGANA 944
            .....|...|                 ....||.|:.                  .|....||:.
  Rat   890 TRARQAVQVL-----------------QPGRDGTGLG------------------LGGGSPGAST 919

  Fly   945 TSTAASGSNSSIAGSTLTLSAQSNTTTHSASTLHGLDGGPSTGGFNSEPASLDSVASMGIIASTS 1009
            ......|..|...|..|
  Rat   920 PVLLPRGGASERQGEAL------------------------------------------------ 936

  Fly  1010 GTERSRDLALCAVLMDEWLKELAAIAQEQSV 1040
               |.::...|||:..|:|||||||:|..:|
  Rat   937 ---RVKNAVYCAVIFPEFLKELAAISQAHAV 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3558	NP_001137777.1	RAI16-like	101..452	CDD:287259	160/355 (45%)
CG3558	NP_001137777.1	LbR-like	898..979	CDD:248061	10/80 (13%)
Fhip1b	NP_001005538.2	RAI16-like	97..426	CDD:370927	160/354 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..510		7/44 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..556		3/31 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346077
Domainoid	1	1.000	297	1.000	Domainoid score	I1401
eggNOG	1	0.900	-	-		E1_KOG3695
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1618
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141539at2759
OrthoFinder	1	1.000	-	-		FOG0003063
OrthoInspector	1	1.000	-	-		oto98722
orthoMCL	1	0.900	-	-		OOG6_105010
Panther	1	1.100	-	-	LDO	PTHR21705
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2039
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800