DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3558 and fhip1aa

DIOPT Version :9

Sequence 1:	NP_001137777.1	Gene:	CG3558 / 48421	FlyBaseID:	FBgn0025681	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	XP_009289541.1	Gene:	fhip1aa / 100000787	ZFINID:	ZDB-GENE-090312-132	Length:	974	Species:	Danio rerio

Alignment Length:	991	Identity:	287/991 - (28%)
Similarity:	448/991 - (45%)	Gaps:	246/991 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 TDCDPRACYDSFCKHWQQAFEIIQ---------------HS------------APPSHDDVLGVV 66
            |..||..|...|..||.|..:|::               |.            .|...|:...|.
Zfish    18 TGVDPETCMIVFKNHWAQVVKILEKHDPLRSNTGGLGGGHGLAGGGGLGSFRFGPIPGDEASAVQ 82

  Fly    67 SHLDYMVTLLLVELHHCNKVSLPAAEASGPPAAPCLEFLLSENLLDKLYEWACTTGRYANAVRLE 131
            :::::|:.||:.|  .|.:..     |.|    |.|||::.||:|::|:.|:... .:.:.::||
Zfish    83 NYVEHMLFLLMEE--ECGQNG-----AMG----PILEFVVMENVLERLFIWSLRR-EFTDDMKLE 135

  Fly   132 QLKLYELLVSHSRHQLLCHEPFLRPLLKILASSQGEIFP-----PDLEKRLVILLNQLCVVLMQN 191
            |||:||:|:..:|..||.|:|.|:||:.:|:|..|.  |     |.:|..||:||||||.||.::
Zfish   136 QLKMYEMLIGQARQPLLHHKPVLKPLMMLLSSCSGS--PTGPSSPAVETELVLLLNQLCCVLAKD 198

  Fly   192 VHLLDLFFFSAQTQVQEQILNGNVAPPKSGTTTNFIIFSLLIPYVHREGSLGHQARDALLLCMAL 256
            ..:|:|||.:::.|                ...||:|||||||::|||||:|.||||||||.|||
Zfish   199 PSVLELFFHTSEDQ----------------GAANFLIFSLLIPFIHREGSVGQQARDALLLIMAL 247

  Fly   257 SQKNSNIGTYIAQYSSICPLLVTGLGGLYSRLPNSIEISSIDWHRITPDDVTEIPELTLFMNALE 321
            |.:|..:..:||:.:..||:|.|||.||||.||..:::.|.:||.:..||..::|.|..|:|:||
Zfish   248 SAENHVVAKHIAENTYFCPVLATGLSGLYSSLPTKLDVPSEEWHCLHRDDWQQLPALVQFLNSLE 312

  Fly   322 FCNAVVQVAHEMIKQQLLDFMYQGFIVPVLGPAILQTLKGKHFQTNIDSQISAMSYLDLILRSIT 386
            |||||:||||..|:.||:.:::.||:||||.||:        .:..::..::..:||||.:||::
Zfish   313 FCNAVIQVAHPSIRDQLVGYIHNGFLVPVLAPAL--------HKLTLEEVMTTTAYLDLFIRSVS 369

  Fly   387 EPGLLRAFVRFLLDTEKFDGERILDALVERLNSPDANLCMVTMALFDTLLGLHCEDLMLELLLKF 451
            ||.||..|:.|:| ..:.|...|||.||.|:|:| ..|..|::|||.||:||:|||:||:|:.|:
Zfish   370 EPALLHTFLSFIL-LHRHDSVHILDTLVSRINTP-FQLGTVSLALFRTLIGLYCEDVMLQLIFKY 432

  Fly   452 MLPGKHVPISHRHKINKIDPYLNSSEFFLELSPDVMKRARDLARPKSVHEPVVSELTPLPSLPSP 516
            ::|..|:.:|.|..:|:.|.|..|:...|.|:|...  :.::..|            ||..|.|.
Zfish   433 LIPCNHMMLSQRRVLNERDCYSVSAAKILALTPSCC--SPEIIPP------------PLRQLDSI 483

  Fly   517 VMSKTIGANWNYYGVH-------------TGDSLYANIQ--AYLFEAHWRIAQCQKDCLKWANSY 566
            :.||  |.:.:..|..             .|..:|.::.  .||::|...|:.|.:.|..|:..|
Zfish   484 LWSK--GTDGSQTGTMETKETLLAEDDCVIGSEIYLDVSYLHYLYDARNSISHCMRACSVWSAPY 546

  Fly   567 --------RYQK------------------------------------------W---------- 571
                    .||:                                          |
Zfish   547 NGENPPPEEYQRSTLDEANRTRSSVATRKKTNSVYNSGPPLKDLSATPGLLDLEWDDSYDACPAQ 611

  Fly   572 --------PRHGQGRVHAHALELARQFF----------SEFGGGPIA--------ANETGEKQLD 610
                    .||.......|..||.|...          |||....:.        ||::|....|
Zfish   612 VHTEEDQETRHIPDEPPEHIQELRRTAIMFVKGSYIEESEFQNDVMVYNLVAQKDANDSGNNYRD 676

  Fly   611 SLQSIGESSGYESFKWRPADEESEATDTTV--ATTASEADMD---HNSSSLSSVLGASGK----- 665
            ..:.. |....|....|..|::::.:::::  ...:...:||   ..|.|...:.|..|:
Zfish   677 PSKPT-EPQKQEVLDGRTTDQKAKNSESSLNNGLNSPVNEMDSKKRGSQSDQKLQGPEGEDLMAQ 740

  Fly   666 -RESWRTSNSNRNELILTD---------LDFSEDLFAQGTVS----------------------- 697
             .|..||..:..|.....|         :|..||.....:.|
Zfish   741 YEELIRTLGAQPNSPTKADSELKSRVDLIDDEEDEMDFNSFSPETPEAEKLPSPFGTKPRSGSKG 805

  Fly   698 -----LGPFLNAIWGKLQTFTSNSLYVNLHLTGLITRLAWYPLPLIHSLLLRSDIAITSDTPSFH 757
                 .|||::.:..:|:...||:|:|||.|||::.:||.||.||:.|.||.:::.......|.:
Zfish   806 HAVPFTGPFVSVLLSRLENMPSNTLHVNLLLTGILAQLAAYPQPLLRSFLLNTNLVFQPSVRSLY 870

  Fly   758 QVLRILKQQIDAELPVTEDSLEIIDVARSSLIDREFRLANARKGNEGSPMHHSQQQQMVTNSGQQ 822
            |||..:|.|||......:||.|::..|:..|:.||   ::.|..........|:..::..||..|
Zfish   871 QVLASVKNQIDVWSSKNKDSSELLTAAQHCLLARE---SSLRDPQSSQAEDASEADRIKRNSAIQ 932

  Fly   823 QGQL-----RSAYATL 833
            ...:     ...|||:
Zfish   933 PKTVVPLSKTEVYATV 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3558	NP_001137777.1	RAI16-like	101..452	CDD:287259	156/355 (44%)
CG3558	NP_001137777.1	LbR-like	898..979	CDD:248061
fhip1aa	XP_009289541.1	RAI16-like	106..433	CDD:287259	156/355 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587037
Domainoid	1	1.000	303	1.000	Domainoid score	I1360
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1600
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141539at2759
OrthoFinder	1	1.000	-	-		FOG0003063
OrthoInspector	1	1.000	-	-		otm26262
orthoMCL	1	0.900	-	-		OOG6_105010
Panther	1	1.100	-	-	O	PTHR21705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4805
SonicParanoid	1	1.000	-	-		X2039
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.930