DRSC/TRiP Functional Genomics Resources

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Protein Alignment NONO and NRD1

DIOPT Version :10

Sequence 1:NP_031389.3 Gene:NONO / 4841 HGNCID:7871 Length:471 Species:Homo sapiens
Sequence 2:NP_014148.1 Gene:NRD1 / 855470 SGDID:S000005195 Length:575 Species:Saccharomyces cerevisiae


Alignment Length:360 Identity:68/360 - (18%)
Similarity:121/360 - (33%) Gaps:111/360 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    12 QNHT-----PRKHHQHHHQQQHHQQQQQQPPPPPI--PANGQQ------ASSQ------------ 51
            |.||     .|:..:...::.:.::.:.:.||.|.  |:.|::      |..|            
Yeast   236 QAHTITEYGSRRERERERERYNSRRNRSRSPPAPFSQPSTGRKDRYPSVAQDQYSIGAPNTTFGT 300

Human    52 -NEGLTIDLKNFRK---------------PGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKA 100
             |..|..|..|...               |.:........||:|.:|.::.|.::..:.:.:.:.
Yeast   301 NNHHLYPDELNVSNNPHYRPKPVSYDSTLPPDHIKVYSRTLFIGGVPLNMKEWDLANVLKPFAEV 365

Human   101 GEVFIHKDKGFGFIRLETRTLAE--IAKVELDN-MPLR---GKQLRVRFAC---HSASLTVRNLP 156
            ..|.::..:...|:::.:|..||  :.....|. :|||   |.....|..|   |..|:    :|
Yeast   366 QSVILNNSRKHAFVKVYSRHEAENVLQNFNKDGALPLRTRWGVGFGPRDCCDYQHGYSI----IP 426

Human   157 QY-----------------------VSNELLEEAFSVFGQVERAVVIVD----DRGRPSGKGIVE 194
            .:                       |:..:.||...:.|:...:..|..    |.||...:    
Yeast   427 MHRLTDADKKWSVSAQWGGTSGQPLVTGIVFEEPDIIVGEGVSSKAISQKMPTDSGRNGPR---- 487

Human   195 FSGKPAARKALDRCSE---GSFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQP-- 254
             ||||....::...|.   |:..|.:.|....|:||.|               |.:.....||  
Yeast   488 -SGKPNKSGSISSISPVPYGNAPLASPPPQQYVQPMMQ---------------QPYGYAPNQPLP 536

Human   255 ---PRFAQP--GSFEYEYAMRWKALIEMEKQQQDQ 284
               |..|.|  ...:::...:..:|:.|..|||.|
Yeast   537 SQGPAAAAPPVPQQQFDPTAQLNSLMNMLNQQQQQ 571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NONONP_031389.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51 10/51 (20%)
DBHS 54..373 56/292 (19%)
RRM1_p54nrb 73..143 CDD:410001 15/75 (20%)
RRM_SF 149..228 CDD:473069 20/108 (19%)
NOPS_p54nrb_PSF_PSPC1 219..311 CDD:240581 17/73 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..471
NRD1NP_014148.1 CID_Nrd1_like 8..149 CDD:340781
RRM_NRD1_SEB1_like 336..412 CDD:409768 15/75 (20%)
Blue background indicates that the domain is not in the aligned region.

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