DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NONO and spen

DIOPT Version :9

Sequence 1:NP_001138880.1 Gene:NONO / 4841 HGNCID:7871 Length:471 Species:Homo sapiens
Sequence 2:NP_722615.1 Gene:spen / 44205 FlyBaseID:FBgn0016977 Length:5560 Species:Drosophila melanogaster


Alignment Length:485 Identity:106/485 - (21%)
Similarity:182/485 - (37%) Gaps:112/485 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    35 QPPPPPIPANGQQA--SSQNEGLTIDLKNFRKP-GEKTFTQRSRLFVGNLPPDITEEEMRKLFEK 96
            ||.|||:|..|:|:  :.|:.|..: .|:...| |.::...|.:|......|..|         .
  Fly  1727 QPAPPPLPEMGKQSRLTGQSSGNNL-TKSLSVPDGPQSSPARVQLQKSASVPGST---------N 1781

Human    97 YGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRFACHSASLTVRNLPQ---Y 158
            .|....           :.|::.|.:......:.:....|..     :..||::.|:. ||   :
  Fly  1782 VGAPSS-----------LSLDSTTASVETSASISSSTSNGNS-----SLTSAAIHVQK-PQQSTF 1829

Human   159 VSNELLEEAFSVFGQ----VERAVVIVDDR------GRPSGKGIVEFSGKPAA---RKALDRCSE 210
            |..|..:::.:...|    ..:.:....|:      .|......::.|.|.|:   ::.....|:
  Fly  1830 VEEEHTKKSGTSTSQSSSSSSKKISSTHDKLHSKHNNRSESDKKIKKSDKNASSSDKRKNSSTSQ 1894

Human   211 GSFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHK-----------------EREQPPRFA 258
            .|...|    |...:...:.||.....|    |||:..|                 |||:..|.|
  Fly  1895 SSKSAT----PRIEDDSSEADDTADKAE----KNQRHEKEKKERQEKREKDLRKQVEREEKDRKA 1951

Human   259 QPGSFEYEYAMRWKALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMR----- 318
            |....|.|.....:...|.|::::.|.||..||..|:...|.|....|.:...:|:..:|     
  Fly  1952 QQEEREKEDRKAKEEEKEREREKKAQEDREKKEREERELREKEQRDKEQKEKEIREKDLREKEQR 2016

Human   319 ----RQEELRRMEELHNQEVQKRKQ--LELRQEEERRRREEEMRRQQEEMMRRQQEGFKGTFPDA 377
                |::|||. ::|..:|:::::|  .||.:|:::|.||...:.|....|..:|||..|     
  Fly  2017 ERDNREKELRD-KDLREKEMREKEQREKELHREKDQREREHREKEQSRRAMDVEQEGRGG----- 2075

Human   378 REQEIRMGQMA----MGGAMGI-------NNRGAMPPAPVPAGTP--APPGPATMMP---DGTLG 426
            |.:|:...|.:    .|.|..:       |...||.  .:..|||  :|..|:...|   ...|.
  Fly  2076 RMRELSSYQKSKMDIAGEASSLTAIDCQHNKENAMD--TIAQGTPGASPSTPSDNTPKERSRKLS 2138

Human   427 LTPPTTERFGQAATME------GIGAIGGT 450
            ...|......:.::.|      |.|:.||:
  Fly  2139 RNSPVRLHKRRLSSQESNHSAGGGGSCGGS 2168

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NONONP_001138880.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51 8/17 (47%)
DBHS 54..373 75/363 (21%)
RRM1_p54nrb 73..143 CDD:410001 8/69 (12%)
RRM_SF 149..228 CDD:418427 15/94 (16%)
NOPS_p54nrb_PSF_PSPC1 219..311 CDD:240581 27/108 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..471 4/8 (50%)
spenNP_722615.1 RRM2_SHARP 555..628 CDD:240795
RRM3_SHARP 654..726 CDD:240796
RRM4_SHARP 727..803 CDD:240797
RILP-like 1997..>2055 CDD:304877 14/58 (24%)
SPOC 5404..5527 CDD:285043
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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