Protein Alignment NONO and nono

DIOPT Version :10

• Sequence 1: NP_031389.3
• Gene: NONO / 4841
• HGNCID: 7871
• Length: 471
• Species: Homo sapiens
• Sequence 2: NP_991398.1
• Gene: nono / 403096
• XenbaseID: XB-GENE-1002494
• Length: 465
• Species: Xenopus tropicalis
• Alignment Length: 472
• Identity: 363/472 - (76%)
• Similarity: 413/472 - (87%)
• Gaps: 8/472 - (1%)

Human     1 MQSNKTFNLEKQNHTPRKHHQHHHQQQHHQQQQQQPPPPPIPANGQQASSQNEGLTIDLKNFRKP 65
            ||.|:.:.:|:|||.||:  |.|.||.|||.||.:...   |.|||||:|.|||:||||||||||
 Frog     1 MQGNRGYRMEQQNHAPRR--QQHQQQHHHQHQQAETTS---PTNGQQATSPNEGVTIDLKNFRKP 60

Human    66 GEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELD 130
            ||||:||||||||||||.|:|||||||||||||||||:|||||||||||||||||||||||.|||
 Frog    61 GEKTYTQRSRLFVGNLPMDVTEEEMRKLFEKYGKAGEIFIHKDKGFGFIRLETRTLAEIAKAELD 125

Human   131 NMPLRGKQLRVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVEF 195
            |:||||||||||||||||||:|:|:||:|||||||||||:||||||.|||||||||.:|||||||
 Frog   126 NLPLRGKQLRVRFACHSASLSVKNIPQFVSNELLEEAFSIFGQVERTVVIVDDRGRSTGKGIVEF 190

Human   196 SGKPAARKALDRCSEGSFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPPRFAQP 260
            :.||:|||||||||:|::|||:||||:||||||||||||||||||::|||...:|||||||||||
 Frog   191 ASKPSARKALDRCSDGAYLLTSFPRPITVEPMDQLDDEEGLPEKLLVKNQMCQREREQPPRFAQP 255

Human   261 GSFEYEYAMRWKALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRRQEELRR 325
            ||||||||||||||||||||||:|||||||||:||:|:|||||||||||||||||||||||||||
 Frog   256 GSFEYEYAMRWKALIEMEKQQQEQVDRNIKEAQEKMEIEMEAARHEHQVMLMRQDLMRRQEELRR 320

Human   326 MEELHNQEVQKRKQLELRQEEERRRREEEMRRQQEEMMRRQQEGFKGTFPDAREQEIRMGQMAMG 390
            |||||:||||||||:|||.||||||||||.|||||||:||||||||.::|||||.:|||.||||.
 Frog   321 MEELHSQEVQKRKQIELRHEEERRRREEETRRQQEEMLRRQQEGFKNSYPDAREADIRMAQMAMP 385

Human   391 GAMGINNRGAMPPAPVPAGTPAPPGPATMMPD-GTLGLTPPTTERFGQAATMEGIGAIGGTPPAF 454
            ||:|:|||.::..:.|.:|..|..||..|||: ..:|:|.|.|||||||..:||:|  |..||||
 Frog   386 GAIGMNNRPSLANSNVASGAAANAGPGAMMPEAAAIGMTSPPTERFGQAPNIEGLG--GANPPAF 448

Human   455 NRAAPGAEFAPNKRRRY 471
            .|..|||:|.|||||||
 Frog   449 PRGTPGADFGPNKRRRY 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NONO	NP_031389.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		24/49 (49%)
		DBHS	54..373		280/318 (88%)
		RRM1_p54nrb	73..143	CDD:410001	64/69 (93%)
		RRM_SF	149..228	CDD:473069	62/78 (79%)
		NOPS_p54nrb_PSF_PSPC1	219..311	CDD:240581	80/91 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..471		17/27 (63%)
nono	NP_991398.1	RRM1_p54nrb	68..138	CDD:410001	64/69 (93%)
		RRM_SF	144..223	CDD:473069	62/78 (79%)
		NOPS_p54nrb	214..307	CDD:240582	81/92 (88%)