DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NONO and nito

DIOPT Version :9

Sequence 1:	NP_001138880.1	Gene:	NONO / 4841	HGNCID:	7871	Length:	471	Species:	Homo sapiens
Sequence 2:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster

Alignment Length:	208	Identity:	51/208 - (24%)
Similarity:	89/208 - (42%)	Gaps:	24/208 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    14 HTPR---------KHHQHHHQQQHHQQQQQQPPPPPIPANGQQASSQNEGLTIDLKNFRKPGEKT 69
            |.||         .||.|.|... ||....:|..|...|..::..|:.:.....|.:. :|.:..
  Fly   248 HPPRGPPLHRGGHPHHLHGHAPP-HQYAPMRPLAPRPHAPYEKPESKKDKFPNYLHHV-QPEDDP 310

Human    70 FTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGEVFIHK-----DKGFGFIRLETRTLAEIAKVEL 129
            .:.|: ||.|||...|.::|:|::|.|||...::.|.:     ...|.|:|.:...:|..||:||
  Fly   311 LSTRT-LFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRAKIEL 374

Human   130 DNMPLRGKQLRVRF--ACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGI 192
            ....:...|.::.:  ...:..:.:..|..:.|...||..|..||.:::   |...:|.|  ...
  Fly   375 SGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKK---IEYQKGEP--YAY 434

Human   193 VEFSGKPAARKAL 205
            :::....||..|:
  Fly   435 IQYETVEAATAAV 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NONO	NP_001138880.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		12/45 (27%)
		DBHS	54..373		38/159 (24%)
		RRM1_p54nrb	73..143	CDD:410001	23/74 (31%)
		RRM_SF	149..228	CDD:418427	13/57 (23%)
		NOPS_p54nrb_PSF_PSPC1	219..311	CDD:240581
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..471
nito	NP_001286174.1	RRM	<56..>223	CDD:223796
		RRM1_Spen	98..175	CDD:240754
		RRM2_Spen	312..390	CDD:240755	23/78 (29%)
		RRM3_Spen	397..467	CDD:240756	13/56 (23%)
		SPOC	630..789	CDD:311609
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154205
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930