Protein Alignment NONO and nono

DIOPT Version :10

• Sequence 1: NP_031389.3
• Gene: NONO / 4841
• HGNCID: 7871
• Length: 471
• Species: Homo sapiens
• Sequence 2: NP_963873.1
• Gene: nono / 321994
• ZFINID: ZDB-GENE-030131-713
• Length: 441
• Species: Danio rerio
• Alignment Length: 477
• Identity: 302/477 - (63%)
• Similarity: 358/477 - (75%)
• Gaps: 42/477 - (8%)

Human     1 MQSNKTFNLEKQNHTPRKHHQHHHQQQHHQQQQQQPPPPPIPANGQ-----QASSQNEGLTIDLK 60
            ||.|:....|:|||.|::       ||.:.||:||..|....:|||     :.||.|.|.||||:
Zfish     1 MQGNRGPRSEQQNHGPQR-------QQPNPQQEQQRKPTGADSNGQHTDAGEQSSPNAGFTIDLQ 58

Human    61 NFRKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIA 125
            ||:||||||:||||||||||||...|||::.|||.|||||.|:||:||:|||||||||:|||:||
Zfish    59 NFKKPGEKTYTQRSRLFVGNLPAGTTEEDVEKLFSKYGKASEIFINKDRGFGFIRLETKTLADIA 123

Human   126 KVELDNMPLRGKQLRVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGK 190
            |.|||:...||:|:|||||.|.|:|||:||||:|||||||||||:||.:|||:|||||||||:||
Zfish   124 KAELDDTIFRGRQIRVRFATHGAALTVKNLPQFVSNELLEEAFSMFGPIERAIVIVDDRGRPTGK 188

Human   191 GIVEFSGKPAARKALDRCSEGSFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPP 255
            |||||:.||:||||||||.:|:||||.||||||:|||:|||:||||||:|:.||..:||||||||
Zfish   189 GIVEFANKPSARKALDRCGDGAFLLTAFPRPVTIEPMEQLDEEEGLPERLINKNPVYHKEREQPP 253

Human   256 RFAQPGSFEYEYAMRWKALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRRQ 320
            |||||||||||||||||||:||||||.:|||||||||:||||.|:||||||||||||||||:|||
Zfish   254 RFAQPGSFEYEYAMRWKALMEMEKQQYEQVDRNIKEAKEKLETELEAARHEHQVMLMRQDLLRRQ 318

Human   321 EELRRMEELHNQEVQKRKQLELRQEEERRRREEEMRRQQEEMMRRQQEGFKGTFPDAREQEIRMG 385
            ||||||||.|:||||||||:||||||||||||||:|...||:||||| |..|.|.:.|:.::|
Zfish   319 EELRRMEEAHSQEVQKRKQMELRQEEERRRREEELRAHSEELMRRQQ-GQGGNFSEKRDPDMR-- 380

Human   386 QMAMGG-AMGINNRGAMPPAPVPAGTPAPPGPATMMPDGTLGLTPPTTERFGQAATMEGIGAIGG 449
             |.||| .||:|..        |.|..|          ...|.|..|:...|.:      |..||
Zfish   381 -MHMGGQGMGMNRN--------PMGGNA----------SNTGSTNLTSNEQGAS------GNPGG 420

Human   450 TPPAFNRAAPGAEFAPNKRRRY 471
            .|..|.|..|. :|..|||||:
Zfish   421 LPLPFPRPGPN-DFGANKRRRF 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NONO	NP_031389.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		19/54 (35%)
		DBHS	54..373		250/318 (79%)
		RRM1_p54nrb	73..143	CDD:410001	49/69 (71%)
		RRM_SF	149..228	CDD:473069	62/78 (79%)
		NOPS_p54nrb_PSF_PSPC1	219..311	CDD:240581	76/91 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..471		12/27 (44%)
nono	NP_963873.1	RRM1_p54nrb	71..141	CDD:410001	49/69 (71%)
		RRM2_p54nrb	147..226	CDD:410004	62/78 (79%)
		NOPS_p54nrb	217..310	CDD:240582	77/92 (84%)