Protein Alignment NONO and mei2

DIOPT Version :10

• Sequence 1: NP_031389.3
• Gene: NONO / 4841
• HGNCID: 7871
• Length: 471
• Species: Homo sapiens
• Sequence 2: NP_594609.1
• Gene: mei2 / 2542080
• PomBaseID: SPAC27D7.03C
• Length: 750
• Species: Schizosaccharomyces pombe
• Alignment Length: 232
• Identity: 46/232 - (19%)
• Similarity: 78/232 - (33%)
• Gaps: 74/232 - (31%)

Human    26 QQHHQQQQQQPPPPPIPANGQQASSQNEGLTIDLKNFRKP---GEKT------------FTQRSR 75
            ||:.....:.||...|.:....:....:.||      |||   |.::            |:..||
pombe   137 QQNISVLSESPPQNGIQSYISSSEQAAQALT------RKPSVTGFRSSSLNSNSDDIDIFSHASR 195

Human    76 -LFVGNLPPDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQL 139
             |||.|||..:....:.:||.|.|..        ||.....|.|..:..:|..::.......|.|
pombe   196 YLFVTNLPRIVPYATLLELFSKLGDV--------KGIDTSSLSTDGICIVAFFDIRQAIQAAKSL 252

Human   140 RVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVER------AVVIVDDRGRPSGKGIVEFSGK 198
            |.:              ::.::.||...|.....:::      .:..:||.   .|:.::...|
pombe   253 RSQ--------------RFFNDRLLYFQFCQRSSIQKMINQGATIQFLDDN---EGQLLLNMQG- 299

Human   199 PAARKALDRCSEGSFL--------LTTFPRPVTVEPM 227
                        ||.|        |.||...:.::|:
pombe   300 ------------GSVLSILQLQSILQTFGPLLIMKPL 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NONO	NP_031389.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		5/24 (21%)
		DBHS	54..373		41/204 (20%)
		RRM1_p54nrb	73..143	CDD:410001	20/70 (29%)
		RRM_SF	149..228	CDD:473069	14/93 (15%)
		NOPS_p54nrb_PSF_PSPC1	219..311	CDD:240581	1/9 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..471
mei2	NP_594609.1	RRM_SF	188..277	CDD:473069	24/110 (22%)
		RRM2_MEI2_fungi	287..362	CDD:240972	11/54 (20%)
		PHA03246	386..>580	CDD:223020
		RRM_2	596..692	CDD:112856