Protein Alignment NONO and nono-1

DIOPT Version :10

• Sequence 1: NP_031389.3
• Gene: NONO / 4841
• HGNCID: 7871
• Length: 471
• Species: Homo sapiens
• Sequence 2: NP_498295.3
• Gene: nono-1 / 175844
• WormBaseID: WBGene00017778
• Length: 562
• Species: Caenorhabditis elegans
• Alignment Length: 424
• Identity: 157/424 - (37%)
• Similarity: 219/424 - (51%)
• Gaps: 63/424 - (14%)

Human    67 EKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDN 131
            :|.||.|.||||||||.::.|.|:::||..:|...|.:: ..|||.|:||:||..||.||..:|.
 Worm   109 KKKFTGRCRLFVGNLPNEVKETELKELFSPHGDIAECYL-SGKGFAFLRLDTRAHAESAKEAIDG 172

Human   132 MPLRGKQLRVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVEFS 196
            ..:.|:|:|||||.|.|::.|:.|...||||:|..|||.||.|||||.|||::|||:|:|||||.
 Worm   173 RIIHGRQVRVRFAVHGAAIRVKELSPTVSNEMLYHAFSHFGDVERAVHIVDEKGRPTGEGIVEFE 237

Human   197 GKPAARKALDRCSEGSFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPPRFAQPG 261
            .||...:|:....:..||||..|:|:..|.::..|:::||.|:::.:.....||||..|||..|.
 Worm   238 RKPNCNEAMAAIRDKVFLLTASPKPLICEVLEPRDEDDGLAERMIPRTPGLSKERELGPRFPTPN 302

Human   262 SFEYEYAMRWKALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRRQEELRRM 326
            ||||.|.|:||.|..:|::::.|:|..::|:|.:||.:||.|..::|..::|:||.|||:||.|:
 Worm   303 SFEYVYGMKWKELYVVEQKRRAQLDEELRESRRRLESDMELAYQDYQAQMLREDLQRRQQELERL 367

Human   327 EELHNQEVQKRKQLELRQEEERRRREEEMRRQQEEMMRRQQEGFKGTFPDAREQEIRMGQMAMGG 391
            |                     ..|.|.||.     :.....|..|..|...:.....|....||
 Worm   368 E---------------------AARRERMRG-----LGGPPPGMPGGVPPQAQPFNPHGGSMFGG 406

Human   392 AMGINNRGAMPPAPVPAGTP----------APPGPATMM--------PDGTLGLTPP-------T 431
            ..|       |..|.|.|.|          .|.||..:|        |.|.:| .||       .
 Worm   407 PGG-------PGGPPPFGQPFQQAPQGMFNVPTGPPPLMGGGGDPRGPPGGMG-GPPGHGGMGGP 463

Human   432 TERFGQAATMEGIGAIGGTPPAFNRAAPGAEFAP 465
            ....||... .|.|.:||.||  .:..||....|
 Worm   464 PGHGGQGGP-PGHGGMGGPPP--GQGGPGGPGGP 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NONO	NP_031389.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51
		DBHS	54..373		126/305 (41%)
		RRM1_p54nrb	73..143	CDD:410001	32/69 (46%)
		RRM_SF	149..228	CDD:473069	39/78 (50%)
		NOPS_p54nrb_PSF_PSPC1	219..311	CDD:240581	35/91 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..471		9/23 (39%)
nono-1	NP_498295.3	RRM1_p54nrb_like	115..184	CDD:409769	32/69 (46%)
		RRM2_p54nrb_like	190..269	CDD:409770	39/78 (50%)
		eNOPS_SF	260..349	CDD:240579	34/88 (39%)