DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc7 and YPP1

DIOPT Version :9

Sequence 1:	NP_652063.1	Gene:	Ttc7 / 48387	FlyBaseID:	FBgn0021847	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_011714.3	Gene:	YPP1 / 853112	SGDID:	S000003430	Length:	817	Species:	Saccharomyces cerevisiae

Alignment Length:	836	Identity:	149/836 - (17%)
Similarity:	272/836 - (32%)	Gaps:	281/836 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 LVSGSSGSSNNSTAGSTLNVNASTVQPSSSSFAIS-STIPASGPS------------GLEMNRRM 246
            |:.||:.:|...:..|.||:          .|.:. ..|.::||:            .||.|..|
Yeast    28 LLGGSTFNSGFDSLDSVLNL----------QFRLHYHVIGSNGPAKPVCDVLLKESQNLEKNMSM 82

  Fly   247 GAILETALQRAPIVLIKTEKL------------QEAVERYRIMLNAIET-RATQSLRLTLARQLA 298
               :| .|...|.:....||:            .:..|..|.:|::::. ..|.|.:..|..|..
Yeast    83 ---ME-ELNDYPEITKLVEKILFNCLGILFFHRGQFQESQRCLLHSLKIHNNTASQKTALMEQYD 143

  Fly   299 EVLLRGVSGTIYSPPFTGKSGGGTLRGGSSKKLWKPRKYAARQQFNPRNQQEEVILLLLIAEALA 363
            ..|:  |....|             ||..|                   |...::..:...|.||
Yeast   144 RYLI--VENLYY-------------RGLVS-------------------QDINIMQNVFYKELLA 174

  Fly   364 VRDTVLSQSPEFRQARQHAMGNVTAVYDLLTLATVRWGLVQLLNES------------------F 410
            ..||:..:|           ..:...|..|.:|.:|:..:|.|.|:                  |
Yeast   175 HVDTIPPES-----------NGLLFEYISLIVAKLRFNQIQDLAENFKTTVENPFILFLYMIKKF 228

  Fly   411 EKALKFSFGEQHVWRQYGLSLM-------AAEKHSHALR----VLQ--------ESMKLTPSDPL 456
            :..||.......::.::|.:::       |:|.:..||.    .||        :.:|:.||...
Yeast   229 QSPLKKHIDNDDLYLKFGQNVLLKAKFPTASETNDEALEHFNVFLQYYFKFTHIKKIKVNPSWYN 293

  Fly   457 PCLLASRLCYESLETVKQGLDYAQQALKR---EVKGLRPSRSQL-----FVGIGHQQLAIQSNLK 513
            ..:.:....::|:|..|..:...|.....   |:|.....|..:     ||....:...:..|
Yeast   294 FIISSMEKTFQSIEVSKTAMFLFQNLSDNSNDEIKKKTFKRESILNFVNFVKYNDKYYQLHDN-- 356

  Fly   514 SERDAC-----------HKLALDALERAVQFDG---------NDHLAEYYL-------------- 544
            |.||..           :....|::|....:|.         |....||.|
Yeast   357 SHRDIISFIDAYSFILQNSSKTDSIENVFDYDNTVSTFATSLNSFYKEYNLPLMSQSESLDWLEN 421

  Fly   545 SLQYALLGQLAEALVHI--------RFALALRMEHAPCLHLFALLLTSSRRPREA------LGVV 595
            |.:....|.:::.|.:.        ::.|...:.:....:|...::.|::....|      .|..
Yeast   422 STRCVYPGNISKVLTNAWSTLYEIRKYQLDFLVSNNLTSYLCNAMMLSTKEKDNADVEEQEEGEE 486

  Fly   596 EDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQ--------------HMLAVWRDVYEAQLAG 646
            |.||.|.  ..:..:..|. |.|:   |||:.|::              |:||:.|.|
Yeast   487 EKALREL--QFKYSYTLAQ-QRHI---ETAIKTLESLILSKNPNYYKAWHLLALCRSV------- 538

  Fly   647 EEEKHSDTK---SGVHLAHSSQMSD----KDSNSVYAASLAAVSRVEQALS--EAASSLSSFTQ- 701
            :|:|....|   |.:...:.|..::    .|........|..::.:|:...  ||..:|....:
Yeast   539 QEDKEMSYKIVCSVLEAMNESLQNNTLLLNDRWQFIHLKLTQLALIEEIFGTLEALETLPEVFEL 603

  Fly   702 --------RP-----GPR----RPWMLQIEIWLLLADVYLRI-DQPNEALNCIHEASQIYPLSHQ 748
                    :|     ||:    :.::||: :|:..|::|:|. |...:|...|.|||.:......
Yeast   604 YATLFPDSQPELNSMGPKYSQTKEYLLQM-VWIFAANMYMRTKDNDEDAKAAIKEASNVESKFKN 667

  Fly   749 I--MFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAE---------- 801
            :  ....|.:.:..::...|.:.|...:..:.|:.:||  :|.|.|:..|....|
Yeast   668 LNCNIANGYLSIIKDEPGVALKEFETVLYYDENNLDAL--VGFAELIFPEELGVEETNLERYYTL 730

  Fly   802 ---------------------------KMLKDAAKLDP----SCPKIWFALGKVME 826
                                       |.|.:.|.|:.    ..|::|:.|..:.|
Yeast   731 SLDKKPGKRAKLTFVNDTDRSAAYARLKFLLECAILESIEAYYSPEVWWYLSLIYE 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TPR	<408..626	CDD:223533	51/310 (16%)
		TPR repeat	420..450	CDD:276809	7/48 (15%)
		TPR repeat	455..484	CDD:276809	4/28 (14%)
		TPR repeat	542..566	CDD:276809	5/45 (11%)
		TPR repeat	571..601	CDD:276809	7/35 (20%)
		TPR_11	712..778	CDD:290150	14/68 (21%)
		TPR repeat	713..741	CDD:276809	9/28 (32%)
		TPR repeat	746..776	CDD:276809	3/31 (10%)
		TPR_11	748..812	CDD:290150	15/102 (15%)
		TPR repeat	781..809	CDD:276809	9/64 (14%)
		TPR_11	782..846	CDD:290150	15/86 (17%)
		TPR_14	782..824	CDD:290164	14/82 (17%)
		TPR repeat	815..843	CDD:276809	4/12 (33%)
YPP1	NP_011714.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23083
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100