DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc7 and NPGR1

DIOPT Version :9

Sequence 1:	NP_652063.1	Gene:	Ttc7 / 48387	FlyBaseID:	FBgn0021847	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_564285.1	Gene:	NPGR1 / 839637	AraportID:	AT1G27460	Length:	694	Species:	Arabidopsis thaliana

Alignment Length:	900	Identity:	177/900 - (19%)
Similarity:	330/900 - (36%)	Gaps:	275/900 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 CRSEGKWHRVIELTDELKTGSPHNECLANFLVGEARLESYLEENALASDSNFGRAKSGLAEARRF 84
            |...|:..|.     |.:.|||.:....:|           ..:.|:|.:..|...|.|.:
plant     3 CACSGEQFRF-----EDQPGSPESLATRDF-----------SASGLSSRNGGGDWDSKLED---- 47

  Fly    85 LHLALGESGQKAGIAL---DAYLLLAKLCFACGEYEQSLDNFVKAELNTL--------AEKEL-- 136
            :.:...||..|..::|   :|..||.:|.:..|.::.:|..|...::..|        .||.|
plant    48 IQVDEAESTLKEALSLNYEEARALLGRLEYQRGNFDAALQVFKGIDIKVLTPRIIKAIVEKTLPC 112

  Fly   137 --------------TLRSLKILAESYAIKGLCLEQQTTKPSSKFKKAEKDTEMISCFERASDLGL 187
                          ::.|:.:|.|:..:|...||:     ...:|:|.::.::|
plant   113 KPRSKAVIVPPTTMSMHSVSLLLEAILLKARSLEE-----LGSYKEAAEECKII----------- 161

  Fly   188 LYLQEYDLVSGSSGSSNNSTAGSTLNVNASTVQPSSSSFAISSTIPASGPSGLEMNRRMGAILET 252
                                    |:|             :.:.:|:..|.|:....::..|.:.
plant   162 ------------------------LDV-------------VENALPSGMPDGISGFAKLQDIFQK 189

  Fly   253 ALQRAPIVLIKTEKLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRGVSGTIYSPPFTGK 317
            ||:..|::..|.....|.:..||..|:.......|.|.:| .:.||.|||
plant   190 ALELLPLLWKKAGNHHETIASYRRALSRPWNLDPQRLAVT-QKSLALVLL--------------- 238

  Fly   318 SGGGTLRGGSSKKLWKPRKYAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPEFRQARQHA 382
                               |.:.:.....|.:|.::||:|:.:.:.|.|  :...||
plant   239 -------------------YGSVEACPKDNIEEAIVLLMLLVKKMVVGD--IQWDPE-------- 274

  Fly   383 MGNVTAVYDLLTLATVRWGLVQLLNESFEKALK--FSFGEQHVWRQYGLSLMAAEKHSHALRVLQ 445
                  :.|.||.|....|..::|....|:.|.  ::.||:  |....|...||.....|:.:|:
plant   275 ------LMDHLTYALSMTGQFEVLANYLEQTLPGVYTRGER--WYLLSLCYSAAGIDKAAINLLK 331

  Fly   446 ESMKLTPSDP-----LPCLL-ASRLCYESLETVKQGLDYAQQAL---KREVKGLRPSRSQLFVGI 501
              |.|.||:.     :|.|| .::||.:..:..:.|:::|.:.|   ..:.:.|. |::..|:|:
plant   332 --MALGPSESRQIPHIPLLLFGAKLCSKDPKHSRDGINFAHRLLDLGNSQSEHLL-SQAHKFLGV 393

  Fly   502 GHQQLAIQSNLKSERDACHKLALDALERAVQFDGNDHLAE--YYLSLQYALLGQLAEALVHIRFA 564
            .:...|..|.|.|||....|.:|.:|..|.:....|...:  :.||::.|:..       :::.|
plant   394 CYGNAARSSKLDSERVFLQKKSLFSLNEAAKRGKADPELDVIFNLSVENAVQR-------NVQAA 451

  Fly   565 LALRMEHAPCL---------HLFALLLTSSRRPREALGVVEDALHEFPD--NLQLLHVKAHLQLH 618
            |...:|::..:         || |::|::.:|.::|..:::..:.|..|  .::||.:||.||:.
plant   452 LDGAVEYSSMVGGVSTKGWKHL-AIVLSAEKRLKDAESILDFTMEEAGDIEKIELLRLKAVLQMA 515

  Fly   619 LEDAETALGTVQHMLAVWRDVYEAQLAGEEEKHSDTKSGVHLAHSSQMSDKDSNSVYAASLAAVS 683
            .|..:.|:.|                                               .:||..:.
plant   516 QEQPKKAMKT-----------------------------------------------CSSLLGLI 533

  Fly   684 RVEQALSEAASSLSSFTQRPGPRRPWMLQIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQ 748
            |.::...::.|.|..|            :.|.|..||.||.::...::|..|:.:|
plant   534 RAQEKSEQSESLLQKF------------ETEAWQDLASVYGKLGSWSDAETCLEKA--------- 577

  Fly   749 IMFMRGQVHVYLEQWFDAKQC-------------FLNAVAANPNHTEALRALGEAHLVLGEPRL- 799
                |...:.....|.:...|             |..:::..|:|..::.::.|..:..|:..|
plant   578 ----RSMCYYSPRGWNETGLCLEAKSLHEEALISFFLSLSIEPDHVPSIVSIAEVMMKSGDESLP 638

  Fly   800 -AEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCPVLPF 853
             |:..|.:|.:|||.....|..||.|.:..|....:|:.:..:.:||.|.||..|
plant   639 TAKSFLMNALRLDPRNHDAWMKLGHVAKKQGLSQQAAEFYQAAYELELSAPVQSF 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TPR	<408..626	CDD:223533	58/241 (24%)
		TPR repeat	420..450	CDD:276809	8/29 (28%)
		TPR repeat	455..484	CDD:276809	8/37 (22%)
		TPR repeat	542..566	CDD:276809	4/23 (17%)
		TPR repeat	571..601	CDD:276809	6/38 (16%)
		TPR_11	712..778	CDD:290150	13/78 (17%)
		TPR repeat	713..741	CDD:276809	9/27 (33%)
		TPR repeat	746..776	CDD:276809	4/42 (10%)
		TPR_11	748..812	CDD:290150	13/78 (17%)
		TPR repeat	781..809	CDD:276809	6/29 (21%)
		TPR_11	782..846	CDD:290150	16/65 (25%)
		TPR_14	782..824	CDD:290164	12/43 (28%)
		TPR repeat	815..843	CDD:276809	6/27 (22%)
NPGR1	NP_564285.1	TPR repeat	470..495	CDD:276809	6/25 (24%)
		TPR repeat	503..545	CDD:276809	12/88 (14%)
		TPR repeat	550..580	CDD:276809	10/42 (24%)
		TPR_11	<584..>684	CDD:330823	20/99 (20%)
		TPR repeat	585..613	CDD:276809	3/27 (11%)
		TPR repeat	618..650	CDD:276809	7/31 (23%)
		TPR repeat	655..683	CDD:276809	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	75	1.000	Domainoid score	I3192
eggNOG	1	0.900	-	-		E1_KOG4162
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I2121
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167932at2759
OrthoFinder	1	1.000	-	-		FOG0001505
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103634
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.730