DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc7 and NPG1

DIOPT Version :9

Sequence 1:	NP_652063.1	Gene:	Ttc7 / 48387	FlyBaseID:	FBgn0021847	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001324372.1	Gene:	NPG1 / 818906	AraportID:	AT2G43040	Length:	704	Species:	Arabidopsis thaliana

Alignment Length:	839	Identity:	185/839 - (22%)
Similarity:	321/839 - (38%)	Gaps:	184/839 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CLANFLVGEARLESYLEENALASDSNFGRAKSGLAEARRFLHLALGESGQKAGIAL---DAYLLL 106
            |.....:....:|:.|:|      .|...|:|.|.|                |::|   :|..||
plant    22 CANGICMKTTEVEAKLDE------GNIQEAESSLRE----------------GLSLNFEEARALL 64

  Fly   107 AKLCFACGEYEQSLDNFVKAELNTLAEKELTLRSLKILAESYAIKGLCLEQQTTKPSSKFKKAEK 171
            .:|.:..|..|.:|..|...:|..                  ||:.|.:.....||::|..:..:
plant    65 GRLEYQRGNLEGALRVFEGIDLQA------------------AIQRLQVSVPLEKPATKKNRPRE 111

  Fly   172 DTEMISCFERASDLGL--LYLQEYDLVSGSSGSSNNSTAGSTLNVNASTVQPSSSSFAISST--I 232
            ..:.:|  :.|::|.|  :||:                |.|...:...|.........:.|.  |
plant   112 PQQSVS--QHAANLVLEAIYLK----------------AKSLQKLGRITEAAHECKSVLDSVEKI 158

  Fly   233 PASGPSGLEMNRRMGAILETALQRAPIVLIKTEKLQEAVERYRIMLNAIETRATQSLRLTLARQL 297
            ...|....:::.::...:..|::..|.:..::...|||:..||..|.: :..........:.:..
plant   159 FQQGIPDAQVDNKLQETVSHAVELLPALWKESGDYQEAISAYRRALLS-QWNLDNDCCARIQKDF 222

  Fly   298 AEVLLRGVSGTIYSPPFTGKSGGGTLRGGSSKKLWKPRKYAARQQFNPRNQQEEVILLLLIAEAL 362
            |..||.  ||...|||..|....|:                    :.|||..||.||||:|.
plant   223 AVFLLH--SGVEASPPSLGSQIEGS--------------------YIPRNNIEEAILLLMIL--- 262

  Fly   363 AVRDTVLSQSPEFRQARQHAMGNV---TAVYDLLTLATVRWGLVQLLNESFEKALKFSFGEQHVW 424
                           .::..:|..   .:|::.||.|........:|.:..|:.:...|.....|
plant   263 ---------------LKKFNLGKAKWDPSVFEHLTFALSLCSQTAVLAKQLEEVMPGVFSRIERW 312

  Fly   425 RQYGLSLMAAEKHSHALRVLQESMKL--TPSDPLPCLLASRLCYESLETVKQGLDYAQQALKREV 487
            ....||..||.::|.|:.:|::|:..  .|.|.:..|||::||.|......:|..|||:|: ...
plant   313 NTLALSYSAAGQNSAAVNLLRKSLHKHEQPDDLVALLLAAKLCSEEPSLAAEGTGYAQRAI-NNA 376

  Fly   488 KGLRPSRSQLFVGIGHQQLAI----QSNLKS---ERDACHKLALDALERAVQFDGNDHLAEYYLS 545
            :|:    .:...|:|.:.|.:    |:.:.:   ||......:|.||:.|:.|:.|:....:.|.
plant   377 QGM----DEHLKGVGLRMLGLCLGKQAKVPTSDFERSRLQSESLKALDGAIAFEHNNPDLIFELG 437

  Fly   546 LQYALLGQLAEALVHIR-FALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFP--DNLQ 607
            :|||....|..|..:.: |..|............||:|::.:|..||..|.:.||.|..  |...
plant   438 VQYAEQRNLKAASRYAKEFIDATGGSVLKGWRFLALVLSAQQRFSEAEVVTDAALDETAKWDQGP 502

  Fly   608 LLHVKAHLQLHLEDAETALGTVQHMLAVWRDVYEAQLAGEEEKHSDTKSGVHLAHSSQMSDKDSN 672
            ||.:||.|::...:...|:.|.:::||    :.:||          .||...|...|||.:...|
plant   503 LLRLKAKLKISQSNPTEAVETYRYLLA----LVQAQ----------RKSFGPLRTLSQMEEDKVN 553

  Fly   673 SVYAASLAAVSRVEQALSEAASSLSSFTQRPGPRRPWMLQIEIWLLLADVYLRIDQPNEALNCIH 737
                                                   :.|:|..||.:|..:...|:...|:.
plant   554 ---------------------------------------EFEVWHGLAYLYSSLSHWNDVEVCLK 579

  Fly   738 EASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLG---EPRL 799
            :|.::...|..::...|::....:::..|...||:.:..:.:......|:|......|   :|.|
plant   580 KAGELKQYSASMLHTEGRMWEGRKEFKPALAAFLDGLLLDGSSVPCKVAVGALLSERGKDHQPTL 644

  Fly   800 --AEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCPVLPFTSI 856
              |..:|.||.::||:..|.|:.||.|.:..|....:.|||..:..||.|.|:..|::|
plant   645 PVARSLLSDALRIDPTNRKAWYYLGMVHKSDGRIADATDCFQAASMLEESDPIESFSTI 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TPR	<408..626	CDD:223533	61/229 (27%)
		TPR repeat	420..450	CDD:276809	9/29 (31%)
		TPR repeat	455..484	CDD:276809	11/28 (39%)
		TPR repeat	542..566	CDD:276809	7/24 (29%)
		TPR repeat	571..601	CDD:276809	9/29 (31%)
		TPR_11	712..778	CDD:290150	13/65 (20%)
		TPR repeat	713..741	CDD:276809	8/27 (30%)
		TPR repeat	746..776	CDD:276809	5/29 (17%)
		TPR_11	748..812	CDD:290150	13/68 (19%)
		TPR repeat	781..809	CDD:276809	9/32 (28%)
		TPR_11	782..846	CDD:290150	21/68 (31%)
		TPR_14	782..824	CDD:290164	15/46 (33%)
		TPR repeat	815..843	CDD:276809	9/27 (33%)
NPG1	NP_001324372.1	PEP_TPR_lipo	436..>696	CDD:274350	73/312 (23%)
		TPR repeat	589..617	CDD:276809	4/27 (15%)
		TPR repeat	622..657	CDD:276809	9/34 (26%)
		TPR repeat	662..688	CDD:276809	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	75	1.000	Domainoid score	I3192
eggNOG	1	0.900	-	-		E1_KOG4162
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I2121
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167932at2759
OrthoFinder	1	1.000	-	-		FOG0001505
OrthoInspector	1	1.000	-	-		oto3890
orthoMCL	1	0.900	-	-		OOG6_103634
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730