DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc7 and TTC7A

DIOPT Version :9

Sequence 1:	NP_652063.1	Gene:	Ttc7 / 48387	FlyBaseID:	FBgn0021847	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001275880.1	Gene:	TTC7A / 57217	HGNCID:	19750	Length:	882	Species:	Homo sapiens

Alignment Length:	923	Identity:	298/923 - (32%)
Similarity:	476/923 - (51%)	Gaps:	110/923 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANKNMRNTTTKVEALIESCRSEGKWHRVIELTDELKT-----------GS-------PHNECLA 47
            ||.|....:..|||:.:|.||:||.|.|:.||..:|:|           ||       |..:...
Human     1 MAAKGAHGSYLKVESELERCRAEGHWDRMPELVRQLQTLSMPGGGGNRRGSPSAAFTFPDTDDFG 65

  Fly    48 NFLVGEARLESYLEEN-ALASDSN--FGRAKSGLAEARRFLHLALGESGQKAGIALDAYLLLAKL 109
            ..|:.||.||..|:|| |...||.  ..:.:..::||:.:|...|...........:|.|:|.||
Human    66 KLLLAEALLEQCLKENHAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYMCEAMLILGKL 130

  Fly   110 CFACGEYEQSLDNFVKAELNTLAEKELTLRSLKILAESYAIKGLCLEQQTTKPSSKFKKAEKDTE 174
            .:..|.|..::..:.:|.::.::.:...|..:::|:|::.||||.||:.....:|:|:..|::.|
Human   131 HYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLSEAFVIKGLSLERLPNSIASRFRLTEREEE 195

  Fly   175 MISCFERASDLGLLYLQEYDLVSGSSGSSNNSTAGSTLNVNASTVQPSSSSFAISSTIPASGPSG 239
            :|:||||||.:..::|||.:      .::||||                     |..:....|..
Human   196 VITCFERASWIAQVFLQELE------KTTNNST---------------------SRHLKGCHPLD 233

  Fly   240 LEMNRRMGAILETALQRAPIVLIKTEKLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRG 304
            .|:.    ..||.|||.|.:..:|...:.:.:...|.:|..:||:|||:.::..|:.||.|||..
Human   234 YELT----YFLEAALQSAYVKNLKKGNIVKGMRELREVLRTVETKATQNFKVMAAKHLAGVLLHS 294

  Fly   305 VSGTIY-------SPPFTGKSGGGTLRGGSSKKLWKPRKYAARQQFNPRNQQEEVILLLLIAEAL 362
            :|...|       .|.|.||.....    :::.|.||..|.....:.|::..||.:|||||:|::
Human   295 LSEECYWSPLSHPLPEFMGKEESSF----ATQALRKPHLYEGDNLYCPKDNIEEALLLLLISESM 355

  Fly   363 AVRDTVLSQSPEFRQARQHAMGNVTAVYDLLTLATVRWGLVQLLNESFEKALKFSFGEQHVWRQY 427
            |.||.|||:.||..:.|..::.|..|:||||::...|.|...:|:|..|:|:||:|||.|:|.|.
Human   356 ATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQV 420

  Fly   428 GLSLMAAEKHSHALRVLQESMKLTPSDPLPCLLASRLCYESLETVKQGLDYAQQ--ALKREVKGL 490
            .||::|..|.::|:.:|:|.:||.||||...|:|:::|..||..:::...:|..  :|..|....
Human   421 ALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGEEAGEF 485

  Fly   491 RPSRSQLFVGIGHQQLAIQSNLKSERDACHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLA 555
            .| :..|.:|:.:...|..:.|||::|..|:.||..||||.|...:|.....|:|||.||:.|::
Human   486 LP-KGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPSDPQVILYVSLQLALVRQIS 549

  Fly   556 EALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLE 620
            .|:..::.||.:|.:.|..|||.|||.::.:..:.||.||..|:.|.|:|..|:..|..|:..|:
Human   550 SAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLK 614

  Fly   621 DAETALGTVQHMLAVWRDVY------------------------EAQLAGEEEKHSD-------- 653
            ..|.||.|.:.:|.:|:.:|                        |....|..||...
Human   615 GPEEALVTCRQVLRLWQTLYSFSQLGDFRSPEGFQTPQRNICNSEIYRGGGLEKDGSFGEGLTMK 679

  Fly   654 TKSGVHL----AHSSQMSDKDSNSVYAASLAAVSRVEQALSEAASSLSSFTQRPGPRRPWMLQIE 714
            .:||:||    ||     |.||.|..|:|:|| ||:|:|:||.  ::.|...:.||.:.|....:
Human   680 KQSGMHLTLPDAH-----DADSGSRRASSIAA-SRLEEAMSEL--TMPSSVLKQGPMQLWTTLEQ 736

  Fly   715 IWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPN 779
            |||..|::::......||..||.||:.::|.||.:::|||::........:|||.:..|:..||:
Human   737 IWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPD 801

  Fly   780 HTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQL 844
            ....:.:||.....||...||:|:|:||.:...:|.:.|..||:|::..|...|:.|||.|:|:|
Human   802 GVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALEL 866

  Fly   845 EPSCPVLPFTSIP 857
            |.|.|||||:.||
Human   867 EASSPVLPFSIIP 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TPR	<408..626	CDD:223533	80/219 (37%)
		TPR repeat	420..450	CDD:276809	11/29 (38%)
		TPR repeat	455..484	CDD:276809	7/30 (23%)
		TPR repeat	542..566	CDD:276809	9/23 (39%)
		TPR repeat	571..601	CDD:276809	12/29 (41%)
		TPR_11	712..778	CDD:290150	20/65 (31%)
		TPR repeat	713..741	CDD:276809	10/27 (37%)
		TPR repeat	746..776	CDD:276809	9/29 (31%)
		TPR_11	748..812	CDD:290150	19/63 (30%)
		TPR repeat	781..809	CDD:276809	10/27 (37%)
		TPR_11	782..846	CDD:290150	23/63 (37%)
		TPR_14	782..824	CDD:290164	14/41 (34%)
		TPR repeat	815..843	CDD:276809	10/27 (37%)
TTC7A	NP_001275880.1	TPR_11	736..800	CDD:290150	20/63 (32%)
		TPR repeat	736..763	CDD:276809	10/26 (38%)
		TPR_2	771..801	CDD:285020	8/29 (28%)
		TPR repeat	771..797	CDD:276809	7/25 (28%)
		TPR_16	773..832	CDD:290168	19/58 (33%)
		TPR repeat	802..832	CDD:276809	10/29 (34%)
		TPR_11	804..867	CDD:290150	22/62 (35%)
		TPR repeat	837..865	CDD:276809	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	365	1.000	Domainoid score	I931
eggNOG	1	0.900	-	-		E1_KOG4162
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1315
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47978
OrthoDB	1	1.010	-	-		D167932at2759
OrthoFinder	1	1.000	-	-		FOG0001505
OrthoInspector	1	1.000	-	-		otm41139
orthoMCL	1	0.900	-	-		OOG6_103634
Panther	1	1.100	-	-	LDO	PTHR23083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840