DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc7 and ttc7b

DIOPT Version :9

Sequence 1:	NP_652063.1	Gene:	Ttc7 / 48387	FlyBaseID:	FBgn0021847	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_009291375.1	Gene:	ttc7b / 568039	ZFINID:	ZDB-GENE-070105-3	Length:	916	Species:	Danio rerio

Alignment Length:	949	Identity:	323/949 - (34%)
Similarity:	498/949 - (52%)	Gaps:	137/949 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RNTTTKVEALIESCRSEGKWHRVIELTDELKTGSPHNECLANFLVGEARLESYLEENALASDSNF 71
            |.:.:::|..||.|||||:|.::.||..:|......|:.|...|:|||:|:.||:||.:...|:.
Zfish     4 RKSGSRLETEIERCRSEGQWDKIPELVRQLSAKLISNDDLGELLLGEAKLQQYLKENPIKQGSSP 68

  Fly    72 GRAKSGLAEARRFLHLALGESGQKAGIALDAYLLLAKLCFACGEYEQSLDNFVKAELNTLAEKEL 136
            ...:..|.|.|:.|..||.....|.....:|.|::||||:...:|.::|:.:.:..|:.:.....
Zfish    69 RGPRPRLQEVRKHLTAALDRGNLKPEYMQEASLIMAKLCYVEADYREALNQYSRVNLDEMQLVGA 133

  Fly   137 TLRSLKILAESYAIKGLCLEQ-QTTKPSSKFKKAEKDTEMISCFERASDLGLLYLQEYDLVSGSS 200
            .:..|.::||:||.||||||: ....||.....|:||.|:|:|:|::.|:.||||||.:... |:
Zfish   134 PVYRLSMIAEAYATKGLCLEKVPMASPSLSNSIADKDQEIITCYEKSGDIALLYLQEVEKAL-SA 197

  Fly   201 GSSNNSTAGSTLNVNASTVQPSSSSFAISSTIPASGPSGLEMNRRMGAILETALQRAPIVLIKTE 265
            |..|.|                          |..||  :...:.:|..|||.||||.::..|..
Zfish   198 GIQNRS--------------------------PKPGP--VTQEQELGYFLETGLQRAHVIHFKNG 234

  Fly   266 KLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRGVSGTIYSPPFTGKSG----GGTLRGG 326
            .|...|.|:|.:|.|:|||.||:||:|:||||||:||||:....|..|......    ...||..
Zfish   235 NLTRGVGRFREILRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPNQSPLDDPLRHS 299

  Fly   327 SSKKLW----KPRKYAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPEFRQARQHAMGNVT 387
            ...|.:    :||.|:....|.|:...||.:|||||:|::|.||.|||:.||....|..::.:.:
Zfish   300 PHAKDYALSRRPRIYSGENLFCPQENTEEALLLLLISESMANRDAVLSRIPEHNNDRIISLQSAS 364

  Fly   388 AVYDLLTLATVRWGLVQLLNESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQESMKLTP 452
            .||||||:|..|.|..::|:|..|:|:||:|.|.|:|.|..||||||.|.:.|::||:|.::|.|
Zfish   365 LVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWFQLALSLMAAGKSARAVKVLKECIRLKP 429

  Fly   453 SDPLPCLLASRLCYESLETVKQG-------LDYAQQALKREVKGLRPSRSQLFVGIGHQQLAIQS 510
            .||...|||.:||..:|..:::|       :|..::|.:...||      .|.:|:.:...|..:
Zfish   430 DDPTIPLLAVKLCIGNLHWLEEGERFAKIVIDMGEKAAEFRAKG------YLAIGLVYSLKATDA 488

  Fly   511 NLKSERDACHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCL 575
            :|:..::...|.||.|.:||......||||.:||:||.|:..|:.|||.::|.||.|:.:....|
Zfish   489 SLRGMQEEYQKKALSAFQRAQSLSPTDHLAVFYLALQLAISRQIPEALGYVRQALQLQGDDVHSL 553

  Fly   576 HLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWRDVY 640
            ||.||||::.:...:||.::|.||.|:|:|..||..|..|:......|.||.:.:.||.:|:..|
Zfish   554 HLLALLLSAQKHYHDALNIIEMALSEYPENFILLFTKVKLETLCRGPEEALLSCKRMLQIWKSCY 618

  Fly   641 ---------------EAQLAGEEEKH-------SDTKSGVHLAHSSQMSD--------------- 668
                           :..:|...:.:       ||.::..|.:.|...|:
Zfish   619 NLTNPSDSGRGSSLLDRAVADRRQLNAMTLPDFSDPETASHASSSLSGSEPVSPLFPLSSLYSPP 683

  Fly   669 ----KDSN--------------------------------------SVYAASLAAVSRVEQALSE 691
                .:||                                      ||:|.|:|| |||||||||
Zfish   684 PPKATESNQRRSSHAFCDHAPRRRFSSASNLPDAFFHGFDSFIGVCSVHATSIAA-SRVEQALSE 747

  Fly   692 AASSLSSFTQRPGPRRPWMLQIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQV 756
            .||||.|...:.||..|||...:|||..|:||:.:.:..||..|..||:.::|:||.::||:|||
Zfish   748 VASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGMGKAAEATACTQEAANLFPMSHNVLFMKGQV 812

  Fly   757 HVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPR---LAEKMLKDAAKLDPSCPKIW 818
            ........:||:.:..|::.:|.|.:.::.||   |:|.:.:   ||||:|:||.:::.:...:|
Zfish   813 AELRGNVDEAKRWYEEALSISPTHVKTMQRLG---LILHQLQRYSLAEKILRDAVQVNSTAHDVW 874

  Fly   819 FALGKVMEILGDFHASADCFATSLQLEPSCPVLPFTSIP 857
            .:||:|::..|:..|:.:||.|:|:||.|||:||||.||
Zfish   875 NSLGEVLQAQGNDAAATECFLTALELEASCPILPFTIIP 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TPR	<408..626	CDD:223533	83/224 (37%)
		TPR repeat	420..450	CDD:276809	15/29 (52%)
		TPR repeat	455..484	CDD:276809	10/35 (29%)
		TPR repeat	542..566	CDD:276809	11/23 (48%)
		TPR repeat	571..601	CDD:276809	12/29 (41%)
		TPR_11	712..778	CDD:290150	22/65 (34%)
		TPR repeat	713..741	CDD:276809	11/27 (41%)
		TPR repeat	746..776	CDD:276809	10/29 (34%)
		TPR_11	748..812	CDD:290150	21/66 (32%)
		TPR repeat	781..809	CDD:276809	11/30 (37%)
		TPR_11	782..846	CDD:290150	22/66 (33%)
		TPR_14	782..824	CDD:290164	14/44 (32%)
		TPR repeat	815..843	CDD:276809	9/27 (33%)
ttc7b	XP_009291375.1	TPR_11	364..429	CDD:290150	32/64 (50%)
		TPR repeat	366..392	CDD:276809	13/25 (52%)
		TPR repeat	397..427	CDD:276809	15/29 (52%)
		TPR repeat	471..510	CDD:276809	12/44 (27%)
		TPR repeat	515..545	CDD:276809	16/29 (55%)
		TPR repeat	550..578	CDD:276809	11/27 (41%)
		TPR_11	769..834	CDD:290150	22/64 (34%)
		TPR repeat	769..797	CDD:276809	11/27 (41%)
		TPR repeat	803..831	CDD:276809	9/27 (33%)
		TPR_11	805..867	CDD:290150	21/64 (33%)
		TPR_2	805..836	CDD:285020	9/30 (30%)
		TPR repeat	836..866	CDD:276809	12/32 (38%)
		TPR_11	842..901	CDD:290150	21/61 (34%)
		TPR repeat	871..899	CDD:276809	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	240	1.000	Domainoid score	I2217
eggNOG	1	0.900	-	-		E1_KOG4162
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14675
Inparanoid	1	1.050	521	1.000	Inparanoid score	I1222
OMA	1	1.010	-	-		QHG47978
OrthoDB	1	1.010	-	-		D167932at2759
OrthoFinder	1	1.000	-	-		FOG0001505
OrthoInspector	1	1.000	-	-		otm25727
orthoMCL	1	0.900	-	-		OOG6_103634
Panther	1	1.100	-	-	O	PTHR23083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3344
SonicParanoid	1	1.000	-	-		X1819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870