DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc7 and ttc7a

DIOPT Version :9

Sequence 1:	NP_652063.1	Gene:	Ttc7 / 48387	FlyBaseID:	FBgn0021847	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_001921229.3	Gene:	ttc7a / 559345	ZFINID:	ZDB-GENE-010319-27	Length:	885	Species:	Danio rerio

Alignment Length:	880	Identity:	293/880 - (33%)
Similarity:	463/880 - (52%)	Gaps:	79/880 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KVEALIESCRSEGKWHRVIELTDELKTGSPH-NECLANFLVGEARLESYLEEN-ALASDSN--FG 72
            ::||.::.||||.:|.::..|.::|.....| ::.....|:.||.||..|.|| .|..:|.  ..
Zfish    48 RLEAEVDRCRSECQWDKIPSLVEQLAAARLHDDDDYRTLLLAEALLEECLLENMTLLKNSTPLTE 112

  Fly    73 RAKSGLAEARRFLHLALGESGQKAGIALDAYLLLAKLCFACGEYEQSLDNFVKAELNTLAEKELT 137
            .::..||.|:..|...|.....:.....:|.|||||:.:..|.|..:.....:|.::....::..
Zfish   113 HSQLKLARAKAQLDSILCRGHLEPHYLNEALLLLAKVHYVQGRYRDAQGMCARAGVDDFTHQDQP 177

  Fly   138 LRSLKILAESYAIKGLCLEQQTTKPSSKFKKAEKDTEMISCFERASDLGLLYLQEYDLVSGSSGS 202
            :..|::|||::.||||.|:.|:...:|:.:.:|::.|..:|:..|.|.|||||||.|
Zfish   178 VYQLRMLAEAFVIKGLSLDHQSMSGASRVRLSEREEECQTCYLMACDAGLLYLQELD-------- 234

  Fly   203 SNNSTAGSTLNVNASTVQPSSSSFAISSTIPASGPSGLEMNRRMGAILETALQRAPIVLIKTEKL 267
                         .:...|||.:...:|::|       ..:...|..|:.|||.|.:.|::...|
Zfish   235 -------------KTVCTPSSKTAKSASSVP-------HFDLDPGFFLQAALQSAYLSLLRKGHL 279

  Fly   268 QEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRGVSGTIY----SPPFTG--KSGGGTLRGG 326
            .:...:.|.:|.|:|:|.:||.|.|:||:||||||..|....|    |||..|  |..|.|....
Zfish   280 AQGTHQLRRVLRAVESRGSQSFRKTVARRLAEVLLGSVCEDAYWGPLSPPPPGWLKKEGATHPKD 344

  Fly   327 ----SSKKLWKPRKYAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPEFRQARQHAMGNVT 387
                |||   .|::|:....|.|::..||.:|:|||.|::|..:.|:|::||.|:||:.:|.:.:
Zfish   345 AIYPSSK---PPQRYSTEGAFCPKDVVEEAVLVLLITESMASGEAVISRTPEHREARESSMQDAS 406

  Fly   388 AVYDLLTLATVRWGLVQLLNESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQESMKLTP 452
            :|||||::...|.|...:|:|..|:|:|||:.|.|:|.|.||||||:.|:..|:.||:|...:.|
Zfish   407 SVYDLLSIGMGRRGQYSMLSECLERAMKFSYNEFHLWYQLGLSLMASGKNEDAVAVLKECAAMRP 471

  Fly   453 SDPLPCLLASRLCYESLE------TVKQGL----DYAQQALKREVKGLRPSRSQLFVGIGHQQLA 507
            .||:|.|||:::|...|.      |:..|:    |.|:::|         :|:.|.:|:.....|
Zfish   472 QDPIPPLLAAKVCINHLHWLEDAVTLSAGVVALGDCAEESL---------ARAHLAIGLCRSLQA 527

  Fly   508 IQSNLKSERDACHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHA 572
            ..:.||::.|..::.||.:|.||...|..|....:|||||:||:.||:||:..::.||.:|.:..
Zfish   528 SDATLKADCDEFNRRALQSLRRAHALDPQDPQISFYLSLQFALVRQLSEAMEPLQLALNVRGDDL 592

  Fly   573 PCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWR 637
            ..|||.||||::.:..:.||..::.||::.|||..||..|..|:..|.....||.|...||.:|:
Zfish   593 HSLHLLALLLSAQKHYQHALDTLKLALNQHPDNFNLLFTKVKLEQVLFGPGAALQTCAEMLQLWQ 657

  Fly   638 DVYEAQLAGEEEKH----------SDTKSGVHLAHSSQMSDKDSNSVYAASLAAVSRVEQALSEA 692
            ..|:.....||:..          |...||:||. .....:.::.|..|.|| ||||:|||:||
Zfish   658 SRYDFTRPSEEDDSNSIPPEPGPLSRKPSGLHLT-LPDFQETETGSQSAPSL-AVSRLEQAMSE- 719

  Fly   693 ASSLSSFTQRPGPRRPWMLQIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVH 757
            .|::|| ..:.||...|.....|||...::::...:..||..|:.||..::|.||.::.::|.|.
Zfish   720 VSAISS-AHKHGPAYIWTTLERIWLQAGELFIADGRMKEAQFCVQEAGTLFPTSHSVLLLKGWVA 783

  Fly   758 VYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALG 822
            .......:||..:..|:|.||.....|..||:..:..|...|.||||:||.::..:..:.|..||
Zfish   784 ELKGNDTEAKSLYDEALAINPRGHHILLHLGKLLVRTGRVGLGEKMLRDAIQVQNTAHEAWSGLG 848

  Fly   823 KVMEILGDFHASADCFATSLQLEPSCPVLPFTSIP 857
            :.::.:|...| .|||.|:|:||.|||:.|||.||
Zfish   849 EALQSIGSPQA-PDCFLTALELESSCPIRPFTIIP 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TPR	<408..626	CDD:223533	82/227 (36%)
		TPR repeat	420..450	CDD:276809	15/29 (52%)
		TPR repeat	455..484	CDD:276809	11/38 (29%)
		TPR repeat	542..566	CDD:276809	12/23 (52%)
		TPR repeat	571..601	CDD:276809	11/29 (38%)
		TPR_11	712..778	CDD:290150	17/65 (26%)
		TPR repeat	713..741	CDD:276809	8/27 (30%)
		TPR repeat	746..776	CDD:276809	7/29 (24%)
		TPR_11	748..812	CDD:290150	19/63 (30%)
		TPR repeat	781..809	CDD:276809	11/27 (41%)
		TPR_11	782..846	CDD:290150	22/63 (35%)
		TPR_14	782..824	CDD:290164	14/41 (34%)
		TPR repeat	815..843	CDD:276809	9/27 (33%)
ttc7a	XP_001921229.3	TPR	<418..586	CDD:223533	64/176 (36%)
		PRK15359	<437..>483	CDD:331681	22/45 (49%)
		TPR repeat	474..501	CDD:276808	8/26 (31%)
		TPR repeat	740..767	CDD:276809	8/26 (31%)
		TPR_11	743..>835	CDD:330823	28/91 (31%)
		TPR repeat	772..802	CDD:276809	7/29 (24%)
		TPR repeat	807..835	CDD:276809	11/27 (41%)
		TPR repeat	841..868	CDD:276809	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	240	1.000	Domainoid score	I2217
eggNOG	1	0.900	-	-		E1_KOG4162
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	521	1.000	Inparanoid score	I1222
OMA	1	1.010	-	-		QHG47978
OrthoDB	1	1.010	-	-		D167932at2759
OrthoFinder	1	1.000	-	-		FOG0001505
OrthoInspector	1	1.000	-	-		otm25727
orthoMCL	1	0.900	-	-		OOG6_103634
Panther	1	1.100	-	-	LDO	PTHR23083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840