DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc7 and Ttc7b

DIOPT Version :9

Sequence 1:	NP_652063.1	Gene:	Ttc7 / 48387	FlyBaseID:	FBgn0021847	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_038968447.1	Gene:	Ttc7b / 362768	RGDID:	1305920	Length:	939	Species:	Rattus norvegicus

Alignment Length:	973	Identity:	319/973 - (32%)
Similarity:	505/973 - (51%)	Gaps:	158/973 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RNTTTKVEALIESCRSEGKWHRVIELTDELKTGSPHNECLANFLVGEARLESYLEENALASDSNF 71
            |...:::|..||.||||.:|.|:.||..:|......|:.:|..|:||::||.:|:|..|...::.
  Rat     4 RKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQHLKEKPLRQGASP 68

  Fly    72 GRAKSGLAEARRFLHLALGESGQKAGIALDAYLLLAKLCFACGEYEQSLDNFVKAELNTLAEKEL 136
            ...:..|.|.|:.|..||.....|:....::.|::|||.:..|:|:::|:.:.:..|:.|....:
  Rat    69 RGPRPQLTEVRKHLTAALDRGNLKSEFLQESNLVMAKLNYVEGDYKEALNIYARVGLDDLPLMAV 133

  Fly   137 TLRSLKILAESYAIKGLCLEQQTTKPSSKFKKAEKDTEMISCFERASDLGLLYLQEYDLVSGSSG 201
            ....|:::||:||.||||||:.....|:.....:::.::|:|:|:|.|:.||||||.:
  Rat   134 PPYRLRMIAEAYATKGLCLEKLPVSSSTSNLHVDREQDVITCYEKAGDIALLYLQEIE------- 191

  Fly   202 SSNNSTAGSTLNVNASTVQPSSSSFAISSTIPASGPSGLEMNRRMGAILETALQRAPIVLIKT-- 264
                       .|..:.:|..|         |..||:  ..::.:|..|||.||||.::..|.
  Rat   192 -----------RVILTNIQNRS---------PKPGPA--PHDQELGFFLETGLQRAHVLYFKNGI 234

  Fly   265 ------EKLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRGVSGTIY-----SPPFTGKS 318
                  :.|...|.|:|.:|.|:|||.||:||:|:||||||:||||:....|     .||.....
  Rat   235 DVHEDQQNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEEPPCQSPL 299

  Fly   319 GGGTLRGGSSKKLWKPRK---YAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPEFRQARQ 380
            .....:|.::|....||:   |:....|.|:...||.:|||||:|::|.||.|||:.||.:..|.
  Rat   300 DDPLRKGANTKTYTLPRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRL 364

  Fly   381 HAMGNVTAVYDLLTLATVRWGLVQLLNESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQ 445
            .::.:.:.||||||:|..|.|..::|:|..|:|:||:|.|.|:|.|:.||||||.|.:.|::||:
  Rat   365 ISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLK 429

  Fly   446 ESMKLTPSDPLPCLLASRLCYESLETVKQG-------LDYAQQALKREVKGLRPSRSQLFVGIGH 503
            |.::|.|.|....|||::||..||..:::.       :|..::..:.:.||      .|.:|:.:
  Rat   430 ECIRLKPDDATIPLLAAKLCVGSLHWLEEAEKFAKTVVDVGEKTSEFKAKG------YLALGLTY 488

  Fly   504 QQLAIQSNLKSERDACHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALR 568
            ...|..::|:..::...:.||.||:||......||.|.:||:||.|:..|:.|||.::|.||.|:
  Rat   489 SLQATDASLRGMQEVLQRKALLALQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQ 553

  Fly   569 MEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHML 633
            .:.|..|||.||||::.:...:||.:::.||.|:|:|..||..|..|:......:.||.|.:|||
  Rat   554 GDDANSLHLLALLLSAQKHHHDALNIIDMALSEYPENFILLFSKVKLESLCRGPDEALLTCKHML 618

  Fly   634 AVWRDVY--------------------------------------EAQL-------AGEEEKHSD 653
            .:|:..|                                      ..||       ..:.|..||
  Rat   619 QIWKSCYNLTNPSVEIINSAASSQSVWMIRDSGRGSSLLDRTIADRRQLNTITLPDFSDPETVSD 683

  Fly   654 ---------TKSGVHL--------------------AHSSQMSDK-------------------- 669
                     |:|.:||                    |||  :||.
  Rat   684 SSSSSSISRTESPLHLFVSSPLHSHPKPDIFVWPPAAHS--LSDPGPHREPSLCNSPEAHFHGFP 746

  Fly   670 ---DSNSVYAASLAAVSRVEQALSEAASSLSSFTQRPGPRRPWMLQIEIWLLLADVYLRIDQPNE 731
               ..:||:|.|:|| |||||||||.||||.|...:.||..|||...:|||..|:||:.|.:|.|
  Rat   747 SLFSVSSVHATSVAA-SRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAE 810

  Fly   732 ALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGE 796
            |..|..||:.::|:||.:::|||||......:.:|::.:..|::.:|.|.::::.|......||.
  Rat   811 ATACTQEAANLFPMSHNVLYMRGQVAELRGNFDEARRWYEEALSISPTHVKSMQRLALVLHQLGR 875

  Fly   797 PRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCPVLPFTSIPLV 859
            ..||||:|:||.:::.:..::|..||:|::..|:..|:.:||.|:|:||.|.|.:|||.||.|
  Rat   876 YSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTVIPRV 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TPR	<408..626	CDD:223533	79/224 (35%)
		TPR repeat	420..450	CDD:276809	15/29 (52%)
		TPR repeat	455..484	CDD:276809	8/35 (23%)
		TPR repeat	542..566	CDD:276809	11/23 (48%)
		TPR repeat	571..601	CDD:276809	12/29 (41%)
		TPR_11	712..778	CDD:290150	23/65 (35%)
		TPR repeat	713..741	CDD:276809	13/27 (48%)
		TPR repeat	746..776	CDD:276809	9/29 (31%)
		TPR_11	748..812	CDD:290150	19/63 (30%)
		TPR repeat	781..809	CDD:276809	10/27 (37%)
		TPR_11	782..846	CDD:290150	21/63 (33%)
		TPR_14	782..824	CDD:290164	13/41 (32%)
		TPR repeat	815..843	CDD:276809	9/27 (33%)
Ttc7b	XP_038968447.1	TPR	373..627	CDD:223533	97/259 (37%)
		TPR repeat	373..399	CDD:276809	13/25 (52%)
		TPR repeat	439..467	CDD:276808	7/27 (26%)
		TPR repeat	557..585	CDD:276809	11/27 (41%)
		3a0801s09	<765..938	CDD:273380	70/172 (41%)
		TPR repeat	792..820	CDD:276809	13/27 (48%)
		TPR repeat	826..854	CDD:276809	8/27 (30%)
		TPR repeat	859..889	CDD:276809	11/29 (38%)
		TPR repeat	894..922	CDD:276809	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4162
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1677
OMA	1	1.010	-	-		QHG47978
OrthoDB	1	1.010	-	-		D167932at2759
OrthoFinder	1	1.000	-	-		FOG0001505
OrthoInspector	1	1.000	-	-		otm45281
orthoMCL	1	0.900	-	-		OOG6_103634
Panther	1	1.100	-	-	O	PTHR23083
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1819
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840