DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc7 and Ttc7a

DIOPT Version :9

Sequence 1:	NP_652063.1	Gene:	Ttc7 / 48387	FlyBaseID:	FBgn0021847	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001094226.1	Gene:	Ttc7a / 362696	RGDID:	1306211	Length:	858	Species:	Rattus norvegicus

Alignment Length:	902	Identity:	292/902 - (32%)
Similarity:	477/902 - (52%)	Gaps:	94/902 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANKNMRNTTTKVEALIESCRSEGKWHRVIELTDEL------------KTGSPHNECLA------ 47
            ||.|....|..|||:.:|.||:||:|.|:.:|...|            :..||....::
  Rat     1 MAAKGAHGTHLKVESEMERCRAEGQWDRMFQLVRHLQVLGISGGGSSNRRSSPSGRFISLDTDDF 65

  Fly    48 -NFLVGEARLESYLEEN---ALASDSNFGRAKSGLAEARRFLHLALGESGQKAGIALDAYLLLAK 108
             ..|:.||.||..|::|   ...|.....:..|.|.|||..|...|...........:|.|:|.|
  Rat    66 GKLLLAEALLEQCLKDNHDKIKNSIPLLEKTDSRLNEARDHLSSILNNGKLPPQYMCEAMLILGK 130

  Fly   109 LCFACGEYEQSLDNFVKAELNTLAEKELTLRSLKILAESYAIKGLCLEQQTTKPSSKFKKAEKDT 173
            |.:..|.|..::..:.:|.::.::.::..|..:::|:|::.||||.||:.....:|..:..|::.
  Rat   131 LHYVEGSYRDAVSMYARAGIDDISVEDKPLYQMRLLSEAFVIKGLSLERLPNSVASHIRLTEREE 195

  Fly   174 EMISCFERASDLGLLYLQEYDLVSGSSGSSNNSTA----GSTLNVNASTVQPSSSSFAISSTIPA 234
            |:::||||||.:..::|||.:      .:|||||:    ||
  Rat   196 EVVACFERASWVAQVFLQELE------KTSNNSTSRHLKGS------------------------ 230

  Fly   235 SGPSGLEMNRRMGAILETALQRAPIVLIKTEKLQEAVERYRIMLNAIETRATQSLRLTLARQLAE 299
                 |.::..:...||.|||.|.:..:|...:.:.:...|.:|..:||:|||:.::..|:.||.
  Rat   231 -----LSVDYELSYFLEAALQSAYVKNLKKGNIVKGMRELREILRTVETKATQNFKVVAAKHLAG 290

  Fly   300 VLLRGVSGTIY-------SPPFTGKSGGGTLRGGSSKKLWKPRKYAARQQFNPRNQQEEVILLLL 357
            |||..:|...|       .|.|..|.....:    ::.|.||..|.....:.|::..||.:||||
  Rat   291 VLLHSLSEDCYWSPLSHPLPEFMSKEENSFI----TQTLRKPHLYEGDNLYCPKDNIEEALLLLL 351

  Fly   358 IAEALAVRDTVLSQSPEFRQARQHAMGNVTAVYDLLTLATVRWGLVQLLNESFEKALKFSFGEQH 422
            |:|::|.||.|||::||..:.|:.::.|.:|:||||::...|.|...:|:|..|:|:|::|||.|
  Rat   352 ISESMATRDVVLSRAPEQEEDRKVSLQNASAIYDLLSITLGRRGQYVMLSECLERAMKYAFGEFH 416

  Fly   423 VWRQYGLSLMAAEKHSHALRVLQESMKLTPSDPLPCLLASRLCYESLETVKQGLDYAQQ--ALKR 485
            :|.|..||::|..|.::|:.:|:|.|||.||:|...|:|:::|..||..:::...:|..  .|..
  Rat   417 LWYQVALSMVACGKSAYAVSLLRECMKLQPSNPTVPLMAAKVCIGSLHWLEEAEHFAMVVIGLGE 481

  Fly   486 EVKGLRPSRSQLFVGIGHQQLAIQSNLKSERDACHKLALDALERAVQFDGNDHLAEYYLSLQYAL 550
            |.....| :..|.:|:.:...|..:.|||::|..|:.||..||||::...:|....:|:|||.||
  Rat   482 EAGEFLP-KGYLALGLTYSLQATDATLKSKQDELHRKALQTLERALELAPDDPQIIFYVSLQLAL 545

  Fly   551 LGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHL 615
            :.|::.|:..::.||.:..:.|..|||.|||.::.:..:.||.|:..|:.|.|:|..|:..|..|
  Rat   546 VRQISSAIERLQEALTVCRDDANALHLLALLFSAQKHHQHALDVINMAITEHPENFNLMFTKVKL 610

  Fly   616 QLHLEDAETALGTVQHMLAVWRDVYE-AQLAGEEEKHS------DTKSGVHL----AHSSQMSDK 669
            :..|:..|.||.|.:.||.:|:.:|. :||.|.|:..|      ..::|:||    ||     |.
  Rat   611 EQVLKGPEEALVTCRQMLRLWQALYNFSQLGGLEKDGSFEGLTVKKQNGIHLTLPDAH-----DA 670

  Fly   670 DSNSVYAASLAAVSRVEQALSEAASSLSSFTQRPGPRRPWMLQIEIWLLLADVYLRIDQPNEALN 734
            ||.|..|:|:|| ||:|:|:||...:.|...|  ||.:.|....:|||..|::::...|..||..
  Rat   671 DSGSRRASSIAA-SRLEEAMSELTITTSVLKQ--GPMQLWTTLEQIWLQAAELFMEQRQLKEAGF 732

  Fly   735 CIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRL 799
            ||.||:.::|.||.:::|||::......:.:|||.:..|:..||:....:.:||.....||...|
  Rat   733 CIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGHKSL 797

  Fly   800 AEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCPVLPFTSI 856
            |:|:|:||.:...:..:.|..||:|::..|...|:||||.|:|:||.|.|||||:.|
  Rat   798 AQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELEASSPVLPFSII 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TPR	<408..626	CDD:223533	76/219 (35%)
		TPR repeat	420..450	CDD:276809	12/29 (41%)
		TPR repeat	455..484	CDD:276809	7/30 (23%)
		TPR repeat	542..566	CDD:276809	9/23 (39%)
		TPR repeat	571..601	CDD:276809	11/29 (38%)
		TPR_11	712..778	CDD:290150	21/65 (32%)
		TPR repeat	713..741	CDD:276809	11/27 (41%)
		TPR repeat	746..776	CDD:276809	9/29 (31%)
		TPR_11	748..812	CDD:290150	19/63 (30%)
		TPR repeat	781..809	CDD:276809	10/27 (37%)
		TPR_11	782..846	CDD:290150	23/63 (37%)
		TPR_14	782..824	CDD:290164	13/41 (32%)
		TPR repeat	815..843	CDD:276809	11/27 (41%)
Ttc7a	NP_001094226.1	TPR repeat	488..527	CDD:276809	15/39 (38%)
		TPR repeat	532..562	CDD:276809	11/29 (38%)
		TPR repeat	567..594	CDD:276809	10/26 (38%)
		TPR_11	712..776	CDD:290150	21/63 (33%)
		TPR repeat	712..739	CDD:276809	11/26 (42%)
		TPR repeat	747..773	CDD:276809	7/25 (28%)
		TPR repeat	778..808	CDD:276809	10/29 (34%)
		TPR_11	781..843	CDD:290150	22/61 (36%)
		TPR repeat	813..841	CDD:276809	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	356	1.000	Domainoid score	I946
eggNOG	1	0.900	-	-		E1_KOG4162
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1677
OMA	1	1.010	-	-		QHG47978
OrthoDB	1	1.010	-	-		D167932at2759
OrthoFinder	1	1.000	-	-		FOG0001505
OrthoInspector	1	1.000	-	-		otm45281
orthoMCL	1	0.900	-	-		OOG6_103634
Panther	1	1.100	-	-	LDO	PTHR23083
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840