DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc7 and Ttc7

DIOPT Version :9

Sequence 1:	NP_652063.1	Gene:	Ttc7 / 48387	FlyBaseID:	FBgn0021847	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_006524264.1	Gene:	Ttc7 / 225049	MGIID:	1920999	Length:	899	Species:	Mus musculus

Alignment Length:	949	Identity:	289/949 - (30%)
Similarity:	474/949 - (49%)	Gaps:	147/949 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANKNMRNTTTKVEALIESCRSEGKWHRVIELTDEL------------KTGSP-------HNECL 46
            ||.|....|..|||:.:|.||:||:|.|:.||...|            :..||       ..:..
Mouse     1 MAAKGAHGTHLKVESEVERCRAEGQWDRMFELARHLQMLGISGGGSSNRRNSPSGRFTTLDTDDF 65

  Fly    47 ANFLVGEARLESYLEENALASDSNFGRAKSG----------LAEARRFLHLALGESGQKAGIALD 101
            ...|:.||.||..|::       |..:.|:.          |.||:..|...|...........:
Mouse    66 VKLLLAEALLEQCLKD-------NHDKIKNSIPLLEKTDHRLNEAKDHLSSLLNNGKLPPQYMCE 123

  Fly   102 AYLLLAKLCFACGEYEQSLDNFVKAELNTLAEKELTLRSLKILAESYAIKGL------------- 153
            |.|:|.||.:..|.|..::..:.:|.::.::.:...|..:::|:|::.||||
Mouse   124 AMLILGKLHYVEGSYRDAVSMYARAGIDDISVENKPLYQMRLLSEAFVIKGLSPTSLAQYVCSLC 188

  Fly   154 -----------------------C-----LEQQTTKPSSKFKKAEKDTEMISCFERASDLGLLYL 190
                                   |     ||:.....:|..:..|::.|:::||||||.:..::|
Mouse   189 PALYSLQHASSFLGEPSPGGQRSCQGGLSLERLPNSVASHIRLTEREEEVVACFERASWVAQVFL 253

  Fly   191 QEYDLVSGSSGSSNNSTA----GSTLNVNASTVQPSSSSFAISSTIPASGPSGLEMNRRMGAILE 251
            ||.:      .:|||||:    ||                             |..:..:...||
Mouse   254 QELE------KTSNNSTSRHLKGS-----------------------------LSPDYELSYFLE 283

  Fly   252 TALQRAPIVLIKTEKLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRGVSGTIY------ 310
            .|||.|.:..:|...:.:.:...|.:|..:||:|||:.::..|:.||.|||..:|...|
Mouse   284 AALQSAYVKNLKKGNIVKGMRELREILRTVETKATQNFKVVAAKHLAGVLLHSLSEDCYWSPLSH 348

  Fly   311 -SPPFTGKSGGGTLRGGSSKKLWKPRKYAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPE 374
             .|.|..|.....:    ::.|.||..|.....:.|::..||.:|||||:|::|.||.|||::||
Mouse   349 PLPEFMNKEENSFV----TQTLRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRAPE 409

  Fly   375 FRQARQHAMGNVTAVYDLLTLATVRWGLVQLLNESFEKALKFSFGEQHVWRQYGLSLMAAEKHSH 439
            ..:.|:.::.|.:|:||||::...|.|...:|:|..|:|:|.:|||.|:|.|..||::|..|.::
Mouse   410 QAEDRKVSLQNASAIYDLLSITLGRRGQYVMLSECLERAMKCAFGEFHLWYQVALSMVACGKSAY 474

  Fly   440 ALRVLQESMKLTPSDPLPCLLASRLCYESLETVKQGLDYAQQAL-KREVKGLRPSRSQLFVGIGH 503
            |:.:|:|.|||.||||...|:|:::|..||..:::...:|...: ..|..|....:..|.:|:.:
Mouse   475 AVSLLRECMKLQPSDPTVPLMAAKVCIGSLHWLEEAEHFATVVIGLGEEAGESLPKGYLALGLTY 539

  Fly   504 QQLAIQSNLKSERDACHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALR 568
            ...|..:.|||::|..|:.||..||||.:...:|....:|::||.||:.|::.|:..::.||.:.
Mouse   540 SLQATDATLKSKQDELHRKALQTLERARELAPDDPQIIFYVALQLALVRQISSAMERLQEALTMC 604

  Fly   569 MEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHML 633
            .:.|..|||.|||.::.:..:.||.|:..|:.|.|:|..|:..|..|:..|:..|.||.|.:.||
Mouse   605 RDDANALHLLALLFSAQKYYQHALDVINMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQML 669

  Fly   634 AVWRDVYE-AQLAGEEEKHS------DTKSGVHL----AHSSQMSDKDSNSVYAASLAAVSRVEQ 687
            .:|:.:|. :||.|.|:..|      ..::|:||    ||     |.||.|..|:|:|| ||:|:
Mouse   670 RLWQTLYNFSQLGGLEKDGSFEGLTVKKQNGIHLTLPDAH-----DADSGSRRASSIAA-SRLEE 728

  Fly   688 ALSEAASSLSSFTQRPGPRRPWMLQIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFM 752
            |:||.  :|::...:.||.:.|....:|||..|::::...|..||..||.||:.::|.||.:::|
Mouse   729 AMSEL--TLTTSVLKQGPMQLWTTLEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYM 791

  Fly   753 RGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKI 817
            ||::......:.:|||.:..|:..||:....:.:||.....||...||:|:|:||.:...:..:.
Mouse   792 RGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEA 856

  Fly   818 WFALGKVMEILGDFHASADCFATSLQLEPSCPVLPFTSI 856
            |..||:|::..|...|:.|||.|:|:||.|.|||||:.|
Mouse   857 WQGLGEVLQDQGQNEAAVDCFLTALELEASSPVLPFSII 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TPR	<408..626	CDD:223533	75/218 (34%)
		TPR repeat	420..450	CDD:276809	12/29 (41%)
		TPR repeat	455..484	CDD:276809	7/29 (24%)
		TPR repeat	542..566	CDD:276809	8/23 (35%)
		TPR repeat	571..601	CDD:276809	11/29 (38%)
		TPR_11	712..778	CDD:290150	21/65 (32%)
		TPR repeat	713..741	CDD:276809	11/27 (41%)
		TPR repeat	746..776	CDD:276809	9/29 (31%)
		TPR_11	748..812	CDD:290150	19/63 (30%)
		TPR repeat	781..809	CDD:276809	10/27 (37%)
		TPR_11	782..846	CDD:290150	22/63 (35%)
		TPR_14	782..824	CDD:290164	13/41 (32%)
		TPR repeat	815..843	CDD:276809	10/27 (37%)
Ttc7	XP_006524264.1	TPR repeat	529..568	CDD:276809	12/38 (32%)
		TPR repeat	573..603	CDD:276809	11/29 (38%)
		TPR repeat	608..635	CDD:276809	10/26 (38%)
		3a0801s09	<646..884	CDD:273380	79/221 (36%)
		TPR repeat	753..780	CDD:276809	8/26 (31%)
		TPR repeat	788..814	CDD:276809	9/25 (36%)
		TPR repeat	819..849	CDD:276809	13/29 (45%)
		TPR repeat	854..882	CDD:276809	1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	348	1.000	Domainoid score	I1028
eggNOG	1	0.900	-	-		E1_KOG4162
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1281
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47978
OrthoDB	1	1.010	-	-		D167932at2759
OrthoFinder	1	1.000	-	-		FOG0001505
OrthoInspector	1	1.000	-	-		otm43209
orthoMCL	1	0.900	-	-		OOG6_103634
Panther	1	1.100	-	-	LDO	PTHR23083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1819
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840