DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc7 and ttc-7

DIOPT Version :9

Sequence 1:	NP_652063.1	Gene:	Ttc7 / 48387	FlyBaseID:	FBgn0021847	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001254845.1	Gene:	ttc-7 / 175332	WormBaseID:	WBGene00021444	Length:	971	Species:	Caenorhabditis elegans

Alignment Length:	996	Identity:	242/996 - (24%)
Similarity:	438/996 - (43%)	Gaps:	182/996 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TKVEALIESCRSEGKWHRVIELTDELKTGSPHNECLANFLVGEARLESYLE---ENALASDSNFG 72
            :::||.|:..|::..|.|:.||...:|:.:...|........|..||:||:   |....|..:..
Worm     7 SRLEAEIDRVRADANWKRLSELLPSVKSKNSGLEDCYEMFQAEIVLETYLDHLGEIIRPSHDHMD 71

  Fly    73 RAKSGLAEARRFLHLALGESGQKAGIALDAYLLLAKLCFACGEYEQSLDNFVKAELNTLAEKELT 137
            :    |:.|.:.||.||........:.::|.:||||..:||.|:.::|.....:|:........|
Worm    72 K----LSSAEQLLHEALKGHSDNYTVKIEANILLAKCLYACLEFRKALQCISNSEMENGKTPFRT 132

  Fly   138 LRSLKILAESYAIKGLCLEQQ----TTKP------SSKFKKAEKDTEMISCFERASDLGLLYLQE 192
            ||:|:::||.|||||||:|..    ||:|      |:....:.||...:..||::::|.:.|:.|
Worm   133 LRTLRLVAEGYAIKGLCIESMEEVPTTRPHSNSTTSTSSSASSKDQRALYVFEKSAELAIFYINE 197

  Fly   193 YDLVSGSSGSSNNSTAGSTLNVNASTVQPSSSSFAISSTIPASGPSGLEMNRRMGAILETALQRA 257
            .:               .::|.::...:|      :.:..|.|..:|:....::|.:||..::|.
Worm   198 LE---------------KSINSSSQAAKP------VGTVTPNSQAAGVRQQEKIGELLERIMERV 241

  Fly   258 PIVLIK---TEKLQ---EAVERYRIMLNAIETRAT-QSLRLTLARQLAEVLLRG---VSGTIYSP 312
            .|:..|   .:|:.   |.:|.||.::..:..:.| :.|:..|:||.||:|:|.   :.....|.
Worm   242 AIIRAKDTAAKKVSSGTEGIEWYRKIITCLGDKFTGERLKQKLSRQFAELLIRATVPIEEKSMSE 306

  Fly   313 PFTGKSGGGTLRGGSSKKLWKPRKYAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPEFRQ 377
            ....|:....|..||:|..           :.|:::.||:||||||.|.|:.|:.:||::.:...
Worm   307 AMHTKAMNMKLYHGSNKTF-----------YTPKSKIEEIILLLLINEVLSTREVILSRTDDLSS 360

  Fly   378 ARQHAMGNVTAVYDLLTLATVRWGLVQLLNESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALR 442
            :|..::.|..:.::||||........|||.:.:|:|:||:..:..:|:|:.||.:...:.|.|:|
Worm   361 SRTLSLQNAKSSFNLLTLVLSTINQYQLLAQIYERAMKFANNDSFLWQQFALSAICCGRFSRAIR 425

  Fly   443 VLQE-------------------------------------------------SMKLT--PSDPL 456
            |.::                                                 |:|||  ||..|
Worm   426 VFEQSILASTIASESLTSSASSTSSISSQNSTSKAQNLHQNRRPKSPDSAMFSSLKLTNNPSCAL 490

  Fly   457 PC----LLASRLCYESLETVKQGLDYAQQAL----KREVKGLRPSRSQLFVGIGHQQLAIQSNLK 513
            ..    ::.|::..|.....:..::||.:|:    |........:|.||...|.:...|.:....
Worm   491 SVISEYMMISQVLIERFGNYEPAIEYASKAVDLCSKEGQLSFLKARCQLLHAIAYGFRASEEPSW 555

  Fly   514 SERDACHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLF 578
            ..:.|.....:..:|..|..|.:|:|:.||.:..:|:...|..|......:|||..:....:.|.
Worm   556 DLKKAQLAKTVQLIEECVSIDAHDYLSLYYAAYFHAISRDLESAKDRCSRSLALNGDQPAAIMLL 620

  Fly   579 ALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWR--DVYE 641
            ||:.|:....:.||.:|.::|.||..|..|:.::.|::......|.:|.|..|:|..|:  ...:
Worm   621 ALIFTAYGDLKGALDLVINSLAEFEHNYGLMVLRLHIETKFGRIEESLDTCSHLLDFWKKQPPVQ 685

  Fly   642 AQLAG-----EEEKHSDTKSGVHL-------AHSSQMSDKDS-----------------NSVYAA 677
            .|||.     :||:...|.:|...       |..||.:...|                 |...::
Worm   686 QQLAYSGGILDEERSQRTINGAAEQLFGGGGATPSQKTGTPSLGRELSTPLATTPLIPMNFPLSS 750

  Fly   678 SLAAVSRV-----EQALSEAASSL--------------SSFTQRPGPRRPW---MLQIEIWLLLA 720
            :|..:|.:     ...||.||.|:              :|.:...|....|   ..|.::|:.||
Worm   751 ALPVISAIPSNASTMDLSGAAESIVGGGASEVGGAASTNSDSLNSGIGDAWSKFRTQADVWMCLA 815

  Fly   721 DVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWF-----------DAKQCFLNAV 774
            ::|:...:..:....|.:|..::|.|.|.::::|::.|...|..           :||..:|.|:
Worm   816 ELYINEGRHADLTKVIEQAITMFPSSPQALYLKGRLLVSRCQKLADETLVSRIRGEAKSAYLAAL 880

  Fly   775 AANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFA 839
            |..|.|.:::.||.:.:...|..::||.||::..::||...:.|..||..:...||...:.:|..
Worm   881 ALAPGHFQSMSALAKLYEEEGNQKMAEHMLREMVRVDPLNCEWWQQLGCSLMKRGDSDRATECLT 945

  Fly   840 TSLQLEPSCPVLPFTSIPLVF 860
            .:.||:.|.|:|||:.:|:||
Worm   946 AAAQLDRSTPLLPFSVVPMVF 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TPR	<408..626	CDD:223533	58/276 (21%)
		TPR repeat	420..450	CDD:276809	9/78 (12%)
		TPR repeat	455..484	CDD:276809	6/36 (17%)
		TPR repeat	542..566	CDD:276809	5/23 (22%)
		TPR repeat	571..601	CDD:276809	8/29 (28%)
		TPR_11	712..778	CDD:290150	18/76 (24%)
		TPR repeat	713..741	CDD:276809	6/27 (22%)
		TPR repeat	746..776	CDD:276809	9/40 (23%)
		TPR_11	748..812	CDD:290150	18/74 (24%)
		TPR repeat	781..809	CDD:276809	7/27 (26%)
		TPR_11	782..846	CDD:290150	17/63 (27%)
		TPR_14	782..824	CDD:290164	12/41 (29%)
		TPR repeat	815..843	CDD:276809	6/27 (22%)
ttc-7	NP_001254845.1	PEP_TPR_lipo	508..>951	CDD:274350	100/442 (23%)
		TPR repeat	579..609	CDD:276809	8/29 (28%)
		TPR repeat	808..836	CDD:276809	6/27 (22%)
		TPR repeat	888..915	CDD:276809	7/26 (27%)
		TPR repeat	920..950	CDD:276809	6/29 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	211	1.000	Domainoid score	I1630
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14675
Inparanoid	1	1.050	259	1.000	Inparanoid score	I1924
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47978
OrthoDB	1	1.010	-	-		D167932at2759
OrthoFinder	1	1.000	-	-		FOG0001505
OrthoInspector	1	1.000	-	-		oto17979
orthoMCL	1	0.900	-	-		OOG6_103634
Panther	1	1.100	-	-	LDO	PTHR23083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3344
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.010