DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc7 and TTC7B

DIOPT Version :9

Sequence 1:	NP_652063.1	Gene:	Ttc7 / 48387	FlyBaseID:	FBgn0021847	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_016876533.1	Gene:	TTC7B / 145567	HGNCID:	19858	Length:	914	Species:	Homo sapiens

Alignment Length:	953	Identity:	324/953 - (33%)
Similarity:	506/953 - (53%)	Gaps:	134/953 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANKNMRNTTTKVEALIESCRSEGKWHRVIELTDELKTGSPHNECLANFLVGEARLESYLEENAL 65
            ||.|   ...:::|..||.||||.:|.|:.||..:|......|:.:|..|:||::||.||:|:.|
Human     1 MATK---KAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEHPL 62

  Fly    66 ASDSNFGRAKSGLAEARRFLHLALGESGQKAGIALDAYLLLAKLCFACGEYEQSLDNFVKAELNT 130
            ...::....|..|.|.|:.|..||.....|:....::.|::|||.:..|:|:::|:.:.:..|:.
Human    63 RQGASPRGPKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIYARVGLDD 127

  Fly   131 LAEKELTLRSLKILAESYAIKGLCLEQQTTKPSSKFKKAEKDTEMISCFERASDLGLLYLQEYDL 195
            |....:....|:::||:||.||||||:.....|:.....:::.::|:|:|:|.|:.||||||.:
Human   128 LPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAGDIALLYLQEIE- 191

  Fly   196 VSGSSGSSNNSTAGSTLNVNASTVQPSSSSFAISSTIPASGPSGLEMNRRMGAILETALQRAPIV 260
                             .|..|.:|..|         |..||:  ..::.:|..|||.||||.::
Human   192 -----------------RVILSNIQNRS---------PKPGPA--PHDQELGFFLETGLQRAHVL 228

  Fly   261 LIKTEKLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRGVSGTIY-----SPPFTGKSGG 320
            ..|...|...|.|:|.:|.|:|||.||:||:|:||||||:||||:....|     .||..... .
Human   229 YFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPCQSPL-D 292

  Fly   321 GTLRGGSSKKLW----KPRKYAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPEFRQARQH 381
            ..||.|::.|.:    :.|.|:....|.|:...||.:|||||:|::|.||.|||:.||.:..|..
Human   293 DPLRKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLI 357

  Fly   382 AMGNVTAVYDLLTLATVRWGLVQLLNESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQE 446
            ::.:.:.||||||:|..|.|..::|:|..|:|:||:|.|.|:|.|:.||||||.|.:.|::||:|
Human   358 SLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKE 422

  Fly   447 SMKLTPSDPLPCLLASRLCYESLETVKQG-------LDYAQQALKREVKGLRPSRSQLFVGIGHQ 504
            .::|.|.|....|||::||..||..:::.       :|..::..:.:.||      .|.:|:.:.
Human   423 CIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKG------YLALGLTYS 481

  Fly   505 QLAIQSNLKSERDACHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRM 569
            ..|..::|:..::...:.||.|.:||......||.|.:||:||.|:..|:.|||.::|.||.|:.
Human   482 LQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQG 546

  Fly   570 EHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHMLA 634
            :.|..|||.||||::.:...:||.:::.||.|:|:|..||..|..||......:.||.|.:|||.
Human   547 DDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQ 611

  Fly   635 VWRDVY---------------------EAQL-------AGEEEKHSD----------TKSGVHLA 661
            :|:..|                     ..||       ..:.|..||          |:|.:||.
Human   612 IWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETVSDSSSSSSPLSRTESPLHLF 676

  Fly   662 HSSQM---------------SDKDS-------------------------NSVYAASLAAVSRVE 686
            .||.:               |..|:                         :||:|.|:|| ||||
Human   677 VSSHLHSPKPDTFVWPPAAHSFSDAGPRREPSLCNSPEAYFHGFPSLFSVSSVHATSVAA-SRVE 740

  Fly   687 QALSEAASSLSSFTQRPGPRRPWMLQIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMF 751
            |||||.||||.|...:.||..|||...:|||..|:||:.|.:|.||..|..||:.::|:||.:::
Human   741 QALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLY 805

  Fly   752 MRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPK 816
            ||||:........:|::.:..|:|.:|.|.::::.|......||...||||:|:||.:::.:..:
Human   806 MRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHE 870

  Fly   817 IWFALGKVMEILGDFHASADCFATSLQLEPSCPVLPFTSIPLV 859
            :|..||:|::..|:..|:.:||.|:|:||.|.|.:|||.||.|
Human   871 VWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTIIPRV 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TPR	<408..626	CDD:223533	79/224 (35%)
		TPR repeat	420..450	CDD:276809	15/29 (52%)
		TPR repeat	455..484	CDD:276809	8/35 (23%)
		TPR repeat	542..566	CDD:276809	11/23 (48%)
		TPR repeat	571..601	CDD:276809	12/29 (41%)
		TPR_11	712..778	CDD:290150	23/65 (35%)
		TPR repeat	713..741	CDD:276809	13/27 (48%)
		TPR repeat	746..776	CDD:276809	8/29 (28%)
		TPR_11	748..812	CDD:290150	19/63 (30%)
		TPR repeat	781..809	CDD:276809	10/27 (37%)
		TPR_11	782..846	CDD:290150	21/63 (33%)
		TPR_14	782..824	CDD:290164	13/41 (32%)
		TPR repeat	815..843	CDD:276809	9/27 (33%)
TTC7B	XP_016876533.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4162
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14675
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1315
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47978
OrthoDB	1	1.010	-	-		D167932at2759
OrthoFinder	1	1.000	-	-		FOG0001505
OrthoInspector	1	1.000	-	-		otm41139
orthoMCL	1	0.900	-	-		OOG6_103634
Panther	1	1.100	-	-	O	PTHR23083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3344
SonicParanoid	1	1.000	-	-		X1819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870