Protein Alignment Ttc7 and Ttc7b

DIOPT Version :10

• Sequence 1: NP_652063.1
• Gene: Ttc7 / 48387
• FlyBaseID: FBgn0021847
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: XP_006515388.1
• Gene: Ttc7b / 104718
• MGIID: 2144724
• Length: 937
• Species: Mus musculus
• Alignment Length: 971
• Identity: 318/971 - (32%)
• Similarity: 506/971 - (52%)
• Gaps: 156/971 - (16%)

  Fly     7 RNTTTKVEALIESCRSEGKWHRVIELTDELKTGSPHNECLANFLVGEARLESYLEENALASDSNF 71
            |...:::|..||.||||.:|.|:.||..:|......|:.:|..|:||::||.:|:|..|...::.
Mouse     4 RKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQHLKEKPLRQGASP 68

  Fly    72 GRAKSGLAEARRFLHLALGESGQKAGIALDAYLLLAKLCFACGEYEQSLDNFVKAELNTLAEKEL 136
            ...:..|.|.|:.|..||.....|:....::.|::|||.:..|:|:::|:.:.:..|:.|....:
Mouse    69 RGPRPQLTEVRKHLTAALDRGNLKSEFLQESNLVMAKLTYVEGDYKEALNIYARVGLDDLPLTAV 133

  Fly   137 TLRSLKILAESYAIKGLCLEQQTTKPSSKFKKAEKDTEMISCFERASDLGLLYLQEYDLVSGSSG 201
            ....|:::||:||.||||||:.....|:.....:::.::|:|:|:|.|:.||||||.:
Mouse   134 PPYRLRMIAEAYATKGLCLEKLPVSSSTSNLHVDREQDVITCYEKAGDIALLYLQEIE------- 191

  Fly   202 SSNNSTAGSTLNVNASTVQPSSSSFAISSTIPASGPSGLEMNRRMGAILETALQRAPIVLIKT-- 264
                       .|..:.:|..|         |..||:  ..::.:|..|||.||||.::..|.
Mouse   192 -----------RVMLTNIQNRS---------PKPGPA--PHDQELGFFLETGLQRAHVLYFKNGI 234

  Fly   265 ------EKLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRGVSGTIY-----SPPFTGKS 318
                  :.|...|.|:|.:|.|:|||.||:||:|:||||||:||||:....|     .||:....
Mouse   235 DVHEDQQNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWSPLEEPPYQSPL 299

  Fly   319 GGGTLRGGSSKKLWKPRK---YAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPEFRQARQ 380
            .....:|.::|....||:   |:....|.|:...||.:|||||:|::|.||.|||:.||.:..|.
Mouse   300 DDPLRKGANTKAYTLPRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRL 364

  Fly   381 HAMGNVTAVYDLLTLATVRWGLVQLLNESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQ 445
            .::.:.:.||||||:|..|.|..::|:|..|:|:||:|.|.|:|.|:.||||||.|.:.|::||:
Mouse   365 ISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLK 429

  Fly   446 ESMKLTPSDPLPCLLASRLCYESLETVKQG-------LDYAQQALKREVKGLRPSRSQLFVGIGH 503
            |.::|.|.|....|||::||..||..:::.       :|..::..:.:.||      .|.:|:.:
Mouse   430 ECIRLKPDDATIPLLAAKLCVGSLHWLEEAEKFAKTVVDVGEKTSEFKAKG------YLALGLTY 488

  Fly   504 QQLAIQSNLKSERDACHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALR 568
            ...|..::|:..::...:.||.|.:||......||.|.:||:||.|:..|:.|||.::|.||.|:
Mouse   489 SLQATDASLRGMQEGLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQ 553

  Fly   569 MEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHML 633
            .:.|..|||.||||::.:...:||.:::.||.|:|:|..||..|..|:......:.||.|.:|||
Mouse   554 GDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLESLCRGPDEALLTCKHML 618

  Fly   634 AVWRDVY---------------------EAQL-------AGEEEKHSD---------TKSGVHL- 660
            .:|:..|                     ..||       ..:.|..||         |:|.:||
Mouse   619 QIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETVSDSSSSSSLSRTESPLHLF 683

  Fly   661 -------------------AHSSQMSD-------------------------------------- 668
                               |||  .||
Mouse   684 VSSPLHSHPKPDIFVWPPAAHS--FSDPGPRHEPSFCNSPEAHFHGFPSLFSVKPLLISSGHAGM 746

  Fly   669 KDSNSVYAASLAAVSRVEQALSEAASSLSSFTQRPGPRRPWMLQIEIWLLLADVYLRIDQPNEAL 733
            :::.||:|.|:|| |||||||||.||||.|...:.||..|||...:|||..|:||:.|.:|.||.
Mouse   747 EEAGSVHATSVAA-SRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEAT 810

  Fly   734 NCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPR 798
            .|..||:.::|:||.:::|||||......:.:|::.:..|::.:|.|.::::.|......||...
Mouse   811 ACTQEAANLFPMSHNVLYMRGQVAELRGHFDEARRWYEEALSISPTHVKSMQRLALVLHQLGRYS 875

  Fly   799 LAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCPVLPFTSIPLV 859
            ||||:|:||.:::.:..::|..||:|::..|:..|:.:||.|:|:||.|.|.:|||.||.|
Mouse   876 LAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTVIPRV 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TTC7_N	7..409	CDD:466084	138/417 (33%)
		LapB	<408..634	CDD:442196	83/232 (36%)
		TPR repeat	420..450	CDD:276809	15/29 (52%)
		TPR repeat	455..484	CDD:276809	8/35 (23%)
		LapB	542..843	CDD:442196	123/395 (31%)
		TPR repeat	542..566	CDD:276809	11/23 (48%)
		TPR repeat	571..601	CDD:276809	12/29 (41%)
		TPR	712..>847	CDD:440225	47/134 (35%)
		TPR repeat	713..741	CDD:276809	13/27 (48%)
		TPR repeat	746..776	CDD:276809	9/29 (31%)
		TPR repeat	781..809	CDD:276809	10/27 (37%)
		TPR repeat	815..843	CDD:276809	9/27 (33%)
Ttc7b	XP_006515388.1	TTC7_N	1..394	CDD:466084	139/418 (33%)
		TPR repeat	373..399	CDD:276809	13/25 (52%)
		LapB	379..619	CDD:442196	87/245 (36%)
		TPR repeat	439..467	CDD:276808	7/27 (26%)
		TPR repeat	557..585	CDD:276809	11/27 (41%)
		TPR	789..>922	CDD:440225	45/132 (34%)
		TPR repeat	790..818	CDD:276809	13/27 (48%)
		TPR repeat	824..852	CDD:276809	8/27 (30%)
		TPR repeat	857..887	CDD:276809	11/29 (38%)
		TPR repeat	892..920	CDD:276809	9/27 (33%)