DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ttc7 and ttc7b

DIOPT Version :9

Sequence 1:	NP_652063.1	Gene:	Ttc7 / 48387	FlyBaseID:	FBgn0021847	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_031762676.1	Gene:	ttc7b / 100037906	XenbaseID:	XB-GENE-5738866	Length:	861	Species:	Xenopus tropicalis

Alignment Length:	903	Identity:	317/903 - (35%)
Similarity:	495/903 - (54%)	Gaps:	87/903 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANKNMRNTTTKVEALIESCRSEGKWHRVIELTDELKTGSPHNECLANFLVGEARLESYLEENAL 65
            ||.|   ...:::|..||.||||.:|.|:.||..:|......|:.:|..|:|||:||.||::|.:
Frog     1 MATK---KAGSRLETEIERCRSECQWDRIHELVKQLSAKLISNDDMAELLLGEAKLEQYLKDNPI 62

  Fly    66 ASDSNFGRAKSGLAEARRFLHLALGESGQKAGIALDAYLLLAKLCFACGEYEQSLDNFVKAELNT 130
            ...::....:..|.:.|:.|..||.....|..:..:..||:|||.:..|:|.::|..:.:..|:.
Frog    63 KQGTSPRGPRPKLTDVRKHLTAALDRGNLKPDLMQEVNLLMAKLNYVEGDYREALSVYARVGLDD 127

  Fly   131 LAEKELTLRSLKILAESYAIKGLCLEQQTTKPSSKFKKAEKDTEMISCFERASDLGLLYLQEYDL 195
            |.........|:::||:::.||||||:..|..|:.....::|.|:|:|:|:|.|:.||||||.:.
Frog   128 LQLVASPAYKLRMIAEAFSTKGLCLEKLPTSSSTNSLHLDRDQEIITCYEKAGDIALLYLQEIER 192

  Fly   196 VSGSSGSSNNSTAGSTLNVNASTVQPSSSSFAISSTIPASGPSGLEMNRRMGAILETALQRAPIV 260
            |             .|.|              :.:..|..||  :..::.:...|||.||||.::
Frog   193 V-------------QTAN--------------LQNRSPKPGP--VAPDQELSFFLETGLQRAHVL 228

  Fly   261 LIKTEKLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRGVSGTIYSPPFTGKSGGGTL-- 323
            ..|...|...|.|:|.:|.|:|||.||:||:|:||||||:||||:....|..|.........|
Frog   229 YFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEEPPNKSPLDD 293

  Fly   324 --RGGSSKKLW----KPRKYAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPEFRQARQHA 382
              |...:.|.:    :|:.|.....|.|:...||.:|||||:|::|.||.|||:.||.:..|..:
Frog   294 PFRHELNTKSYPLSRRPKVYMGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKNDRIIS 358

  Fly   383 MGNVTAVYDLLTLATVRWGLVQLLNESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQES 447
            :.:.:.||||||:|..|.|..::|:|..|:|:||:|.|.|:|.|:.||||||.|.:.|::||:|.
Frog   359 LQSASVVYDLLTIALGRRGQFEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLREC 423

  Fly   448 MKLTPSDPLPCLLASRLCYESLETVKQGLDYAQQAL-----KREVKGLRPSRSQLFVGIGHQQLA 507
            ::|.|.|....|||::||..||..:::...:|:..:     ..|.|    ::..|.:|:.:...|
Frog   424 IRLKPEDATIPLLAAKLCMGSLHWMEEAERFAKMVVDCGEKSPEFK----AKGYLALGLTYSLQA 484

  Fly   508 IQSNLKSERDACHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHA 572
            ..::|:..::...:.||.|..||......||||.:||:||.|:..|:.|||.::|.||.|:.:.:
Frog   485 SDASLRGVQEDLQRKALLAFHRAHSLSPTDHLAAFYLALQLAISRQIPEALGYVRQALQLQGDDS 549

  Fly   573 PCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWR 637
            ..|||.||||::.:...:||.:::.||.|:|:|..||..|..|:......:.||.|.:|||.:|:
Frog   550 NSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLESLCRGPDEALLTCKHMLQIWK 614

  Fly   638 DVYEAQLAGEEEKHSDTKSGVHL-----AHSSQM--------SDKDS------------------ 671
            ..|..      ...||:..|..|     |...|:        ||.::
Frog   615 SCYNL------TNPSDSGRGSSLLDRAIADRRQLNTITLPDFSDPETGCSSEAPHTHGFYSMFSV 673

  Fly   672 NSVYAASLAAVSRVEQALSEAASSLSSFTQRPGPRRPWMLQIEIWLLLADVYLRIDQPNEALNCI 736
            .||:|.|:|| |||||||||.||||.|...:.||..|||...:|||..|:||:.|.:|.||..|:
Frog   674 RSVHATSIAA-SRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPTEATACV 737

  Fly   737 HEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAE 801
            .||:.::|:||.:::|||||........|||:.:..|::.:|.|.::::.|......||...|||
Frog   738 QEAANLFPMSHNVLYMRGQVAELRGNIDDAKRWYEEALSISPTHVKSMQRLSLILHHLGRYSLAE 802

  Fly   802 KMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCPVLPFTSIPLV 859
            |:|:||.:::.:..::|.:||:|::..|:..|:.:||.|:|:||.|.||:|||.||.|
Frog   803 KILRDAVQVNSTAHEVWNSLGEVLQAQGNDDAATECFLTALELEASSPVVPFTIIPRV 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc7	NP_652063.1	TPR	<408..626	CDD:223533	78/222 (35%)
		TPR repeat	420..450	CDD:276809	15/29 (52%)
		TPR repeat	455..484	CDD:276809	8/33 (24%)
		TPR repeat	542..566	CDD:276809	11/23 (48%)
		TPR repeat	571..601	CDD:276809	11/29 (38%)
		TPR_11	712..778	CDD:290150	25/65 (38%)
		TPR repeat	713..741	CDD:276809	13/27 (48%)
		TPR repeat	746..776	CDD:276809	11/29 (38%)
		TPR_11	748..812	CDD:290150	21/63 (33%)
		TPR repeat	781..809	CDD:276809	10/27 (37%)
		TPR_11	782..846	CDD:290150	21/63 (33%)
		TPR_14	782..824	CDD:290164	13/41 (32%)
		TPR repeat	815..843	CDD:276809	9/27 (33%)
ttc7b	XP_031762676.1	TPR repeat	365..391	CDD:276809	13/25 (52%)
		PEP_TPR_lipo	<407..>851	CDD:274350	157/454 (35%)
		TPR repeat	431..459	CDD:276808	8/27 (30%)
		TPR repeat	549..577	CDD:276809	10/27 (37%)
		3a0801s09	<687..860	CDD:273380	73/172 (42%)
		TPR repeat	714..742	CDD:276809	13/27 (48%)
		TPR repeat	748..776	CDD:276809	10/27 (37%)
		TPR repeat	781..811	CDD:276809	11/29 (38%)
		TPR repeat	816..844	CDD:276809	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14675
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1651
OMA	1	1.010	-	-		QHG47978
OrthoDB	1	1.010	-	-		D167932at2759
OrthoFinder	1	1.000	-	-		FOG0001505
OrthoInspector	1	1.000	-	-		otm48345
Panther	1	1.100	-	-	O	PTHR23083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3344
SonicParanoid	1	1.000	-	-		X1819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110