Protein Alignment GstD8 and CLIC2

DIOPT Version :10

• Sequence 1: NP_524916.1
• Gene: GstD8 / 48341
• FlyBaseID: FBgn0010044
• Length: 212
• Species: Drosophila melanogaster
• Sequence 2: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Alignment Length: 213
• Identity: 55/213 - (25%)
• Similarity: 84/213 - (39%)
• Gaps: 64/213 - (30%)

  Fly    12 CRSVIMTAKALGVDLNMKLLKV-MDGEQLK-------PEFVKLNPQHCIPTLVDDGFSIWESRAI 68
            |:.:.|.....||..|:..:.: ...|:||       |.|:..|.:     |..|...|.|
Human    33 CQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKE-----LKTDFIKIEE---- 88

  Fly    69 LIYLVEKYGADDSLYPS-DPQKKAVVNQRLYFDMG-TLFQSFVEAIYPQIRNNHPADPEAMQKVD 131
               .:|:..|... ||. .|:.|.      .||:| .||..|  :.|  |:|   ...||.:..:
Human    89 ---FLEQTLAPPR-YPHLSPKYKE------SFDVGCNLFAKF--SAY--IKN---TQKEANKNFE 136

  Fly   132 SA----FGHLDTFLE-------DQE-----------YVAGDCLTIADIALLASVSTFEVV----- 169
            .:    |..||.:|.       |.:           ::.||.||:||.:||..::..:|.
Human   137 KSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYR 201

  Fly   170 DFDI-AQYPNVARWYENA 186
            |||| |::..|.|:..||
Human   202 DFDIPAEFSGVWRYLHNA 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GstD8	NP_524916.1	GST_N_Delta_Epsilon	1..74	CDD:239343	15/69 (22%)
		GST_C_Delta_Epsilon	88..204	CDD:198287	35/128 (27%)
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		16/74 (22%)
		N-terminal	1..94		16/72 (22%)
		O-ClC	12..245	CDD:129941	55/213 (26%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33		55/213 (26%)
		Joint loop	95..106		4/11 (36%)
		C-terminal	107..247		35/126 (28%)
		Foot loop	151..171		1/19 (5%)