DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstD4 and CLIC4

DIOPT Version :9

Sequence 1:	NP_524913.1	Gene:	GstD4 / 48337	FlyBaseID:	FBgn0010040	Length:	215	Species:	Drosophila melanogaster
Sequence 2:	NP_039234.1	Gene:	CLIC4 / 25932	HGNCID:	13518	Length:	253	Species:	Homo sapiens

Alignment Length:	157	Identity:	35/157 - (22%)
Similarity:	63/157 - (40%)	Gaps:	45/157 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PEFLKLNPQHTIPTLVDNGFAIWESRAIAVYLVEK---YGKDDSLFPNDPQKRALIN--QRLYFD 100
            |::|||:|:|.            ||....:.:..|   |.|:.....|:..:|.|:.  |:|
Human   102 PKYLKLSPKHP------------ESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKL--- 151

  Fly   101 MGTLHDSFMKYYYPFIRTGQLGNAENYKKVEAAFEFLDIFLEGQDYVAGSQLTVADIAILSSVST 165
                 |.::        ...|.:..:...:|      ||....:.::.|:::|:||..:|..:..
Human   152 -----DEYL--------NSPLPDEIDENSME------DIKFSTRKFLDGNEMTLADCNLLPKLHI 197

  Fly   166 FEVV-----EFDISK-YPNVARWYANA 186
            .:||     .|||.| ...:.|:..||
Human   198 VKVVAKKYRNFDIPKEMTGIWRYLTNA 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstD4	NP_524913.1	PRK10542	1..184	CDD:182533	33/153 (22%)
		GST_N_Delta_Epsilon	1..74	CDD:239343	8/32 (25%)
		GST_C_Delta_Epsilon	88..204	CDD:198287	23/107 (21%)
CLIC4	NP_039234.1	Required for insertion into the membrane. /evidence=ECO:0000305	2..101
CLIC4	NP_039234.1	O-ClC	17..252	CDD:129941	35/157 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154229
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930