DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstD3 and MARS1

DIOPT Version :9

Sequence 1:	NP_788656.1	Gene:	GstD3 / 48336	FlyBaseID:	FBgn0010039	Length:	199	Species:	Drosophila melanogaster
Sequence 2:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens

Alignment Length:	146	Identity:	34/146 - (23%)
Similarity:	67/146 - (45%)	Gaps:	22/146 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GKALGLEFNKKIINTLKGEQMNPDFIKINPQHSIPTL-VDNGFTIWESRAILVY--LVEKYGKDD 64
            |:|.|..  :.:|:|:..|.....|:   .:..:|.| :|:|..::.:.||..|  |:..:.:||
Human    20 GRARGRA--EVLISTVGPEDCVVPFL---TRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDD 79

  Fly    65 ALYPKDIQKQAVINQRLYFDMALMYPTLANYYYKAFTTGQFGSEEDYKKVQETFDFLNTFLEGQD 129
                       :.||.|.::...:.|.|:...|.....|:.| |:....|:.....::..|..|:
Human    80 -----------LTNQWLEWEATELQPALSAALYYLVVQGKKG-EDVLGSVRRALTHIDHSLSRQN 132

  Fly   130 --YVAGDQYTVADIAI 143
              ::||:..::|||.:
Human   133 CPFLAGETESLADIVL 148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstD3	NP_788656.1	GST_N_Delta_Epsilon	<1..58	CDD:239343	15/57 (26%)
		GstA	6..173	CDD:223698	32/143 (22%)
		GST_C_Delta_Epsilon	72..188	CDD:198287	17/74 (23%)
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274	10/43 (23%)
		GstA	<47..189	CDD:223698	27/114 (24%)
		GST_C_MetRS_N	77..179	CDD:198340	19/84 (23%)
		PRK12268	264..819	CDD:237029
		MetRS_core	265..633	CDD:173907
		'HIGH' region	273..283
		'KMSKS' region	593..597
		Anticodon_Ia_Met	642..771	CDD:153411
		MetRS_RNA	845..889	CDD:238475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810