DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttk and ZBTB24

DIOPT Version :9

Sequence 1:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_055612.2	Gene:	ZBTB24 / 9841	HGNCID:	21143	Length:	697	Species:	Homo sapiens

Alignment Length:	850	Identity:	167/850 - (19%)
Similarity:	271/850 - (31%)	Gaps:	306/850 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 HQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPE-KHPIVILKDVP 78
            |...:|:.|:.........|:||.||..|.:|||.:|:|.|.||:.:|....| ...|.:|:.:.
Human    19 HSDTVLASFEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMV 83

  Fly    79 YSDMKSLLDFMYRG-----EVSVDQERLTA-FLRVAESLRIKGLTEVNDDKPSPAAAAAGAGATG 137
            ......||:|:|.|     |.|.:|...|| ||:|.:  .:|..|:..::..||
Human    84 ADTFGILLEFIYTGYLHASEKSTEQILATAQFLKVYD--LVKAYTDFQNNHSSP----------- 135

  Fly   138 SESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKRKRGRPRKL 202
            ..:|..|                  ||..:...:|..|.|              ||||||||:|:
Human   136 KPTTLNT------------------AGAPVVVISNKKNDP--------------PKRKRGRPKKV 168

  Fly   203 SGSSNGTGNDYDDFDRENMMNDSSD-------LGNGKMCNESYSGNDDGSDDNQPNA-------- 252
            :...........:.:.:..:|:|..       .|:..:.||..:..:  .::::|..
Human   169 NTLQEEKSELAAEEEIQLRVNNSVQNRQNFVVKGDSGVLNEQIAAKE--KEESEPTCEPSREEEM 231

  Fly   253 ---------GHTDDLNESRDSLPSK----RSKNSKDHRVVSHHEDNSTSVTPTKATPELSQRLFG 304
                     ..|:| .::..|..||    ||...||:::|...||:.:           ::|:.|
Human   232 PVEKDENYDPKTED-GQASQSRYSKRRIWRSVKLKDYKLVGDQEDHGS-----------AKRICG 284

  Fly   305 SSSTTISATAPGGSSTGPSETISLLEISDERESAPVHLPTILGLKIRAINTTTPAQQGSPQTPTK 369
                                          |...|                      |.|:...|
Human   285 ------------------------------RRKRP----------------------GGPEARCK 297

  Fly   370 SKPKIRQATGSNNSNSLLKQQLRGGAKDPEVPPATRITGAVTPNAALNAEEQSKEMPKKNQDEVN 434
            ...|:.:      .|..|                           |::....:.|.|.|    .|
Human   298 DCGKVFK------YNHFL---------------------------AIHQRSHTGERPFK----CN 325

  Fly   435 AC---------IGLHSLANAAEQ-QAAQVASTG-NLHHQLLLHMAANNSMLNTTDYYQQQQQESP 488
            .|         :.:|:..:..|: ....|.|.. ...|.||.||:.::.          |:..:.
Human   326 ECGKGFAQKHSLQVHTRMHTGERPYTCTVCSKALTTKHSLLEHMSLHSG----------QKSFTC 380

  Fly   489 SSAGQFMDDDLELLSLNDQQDKSDEPDHEMVTLADENAGLPGYQGNEAEATPAQEDSP------- 546
            ...|::...:.:|.|            |              |:.:...:.|..:|..
Human   381 DQCGKYFSQNRQLKS------------H--------------YRVHTGHSLPECKDCHRKFMDVS 419

  Fly   547 ------AAETATAPPPAPRSGKK-GAKRPIQRR-RVRRKAQSTLDDQAEHLTEMSVRGLDLFRYA 603
                  ...|...|......||. .||..:|.. |:.|.
Human   420 QLKKHLRTHTGEKPFTCEICGKSFTAKSSLQTHIRIHRG-------------------------- 458

  Fly   604 SVVEGVYRCTECAKENMQKTFKNKYSFQRHAFLYHEGKHRKVFPCPVCSKEFSRPDKMKNHLKMT 668
               |..|.|..|.     |:|.:..:.:||..| |.||  |.|.||.|:.:|:|.|.:|.|||:
Human   459 ---EKPYSCGICG-----KSFSDSSAKRRHCIL-HTGK--KPFSCPECNLQFARLDNLKAHLKI- 511

  Fly   669 HENFTPPKDIGAFSPLKYLISAAAAGDMHATIYQQQQDHYHRQLAEQLEQQNASFDSRDSSLILP 733
            |.......|..:       ||.::..:....|.|.|.  |....:.:.|.|....||..:...:|
Human   512 HSKEKHASDASS-------ISGSSNTEEVRNILQLQP--YQLSTSGEQEIQLLVTDSVHNINFMP 567

  Fly   734 D-------VKMEHAEDQDAEQEAELSDGGYDASNPAAAAAAMLSLQQD----VIIKDEIQISPSP 787
            .       |..|.:::..|:|.|.|:   .....|......:||.||:    :...:.|:....|
Human   568 GPSQGISIVTAESSQNMTADQAANLT---LLTQQPEQLQNLILSAQQEQTEHIQSLNMIESQMGP 629

  Fly   788 SPTPP 792
            |.|.|
Human   630 SQTEP 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_001189329.1	BTB	23..119	CDD:279045	34/102 (33%)
		BTB	34..119	CDD:197585	33/91 (36%)
		C2H2 Zn finger	612..638	CDD:275370	7/25 (28%)
		zf-C2H2_4	646..669	CDD:290605	11/22 (50%)
		C2H2 Zn finger	648..669	CDD:275370	10/20 (50%)
ZBTB24	NP_055612.2	BTB	27..133	CDD:306997	34/107 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..176		18/87 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..254		5/47 (11%)
		C2H2 Zn finger	296..316	CDD:275368	5/52 (10%)
		COG5048	<321..480	CDD:227381	36/232 (16%)
		C2H2 Zn finger	324..344	CDD:275368	3/19 (16%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		C2H2 Zn finger	380..400	CDD:275368	5/45 (11%)
		C2H2 Zn finger	408..428	CDD:275368	1/19 (5%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	464..480	CDD:275368	4/20 (20%)
		C2H2 Zn finger	492..512	CDD:275368	10/20 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910