DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttk and BTBD18

DIOPT Version :9

Sequence 1:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001138573.1	Gene:	BTBD18 / 643376	HGNCID:	37214	Length:	712	Species:	Homo sapiens

Alignment Length:	868	Identity:	164/868 - (18%)
Similarity:	272/868 - (31%)	Gaps:	327/868 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 FDQLLH---AETFTDVTLAVEGQHLKAHKMVLSACSPYF-NTLFVSHPEKHPIVILK--DVPYSD 81
            |.||.|   ::.|.||.|..||:.:.||..:||||||:| ..|....|.:...|:|:  .:..|.
Human    21 FLQLHHQQQSDVFCDVLLQAEGEAVPAHCCILSACSPFFTERLERERPAQGGKVVLELGGLKIST 85

  Fly    82 MKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDD------------------KPSPAA 128
            ::.|:||:|..|:.|.||.....|..|..||:..|..:..:                  :|:.||
Human    86 LRKLVDFLYTSEMEVSQEEAQDVLSAARQLRVSELESLQLEGGKLVKAPQGRRLNRECLQPTSAA 150

  Fly   129 AAAGAGATGSE------STATTP------QLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPV 181
            ..:....|.|.      .|..||      :|:.:.....||.|..|         ||.|
Human   151 PISARVVTPSHHPHTPLPTNQTPCPLGAIRLKSLGKEEGPQENNRQ---------NADN------ 200

  Fly   182 QPSLLSSALMPKRKRGRPRKLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKMCNESYSGNDDGSD 246
                ||..|:.|||                                   .:.|
Human   201 ----LSGTLLLKRK-----------------------------------ARAC------------ 214

  Fly   247 DNQPNAGHTDDLNESRDSLPSKRSKNSKDHRVVSHHEDNSTSVTPTKATPELSQRLFGSSSTTI- 310
               |..       :.::|.||..|:..::::       |.|::.||..:|   ..|:.|....:
Human   215 ---PTP-------QEKNSSPSSHSQEPRENK-------NDTALDPTVLSP---PSLYPSVDKHLL 259

  Fly   311 --------SATAPGGSSTGPSETISLLEISDERESAPVHLPTILGLKI---RAINTTTPAQQGSP 364
                    |..:||..::.||..:          |....:|...|.::   |::|..||..:..|
Human   260 PRKIRLSRSKPSPGICTSKPSSIL----------SGSSSVPATPGRRLWRQRSVNKETPEDKPKP 314

  Fly   365 --QTPTKSKPK---IRQATGSNNSNSLLKQQLRGGAKDPEVPPATRITGAVTPNAALNAE--EQS 422
              .:|.:|.|.   :.:..||...:..::......|::.:|       |.|.....:|..  |..
Human   315 GRASPLQSTPNPSGLGKTGGSRKRSPEVRAPNSDSAEEGQV-------GRVKLRKIVNGTCWEVV 372

  Fly   423 KEMPKKNQDEVNACIGLHSLANAAEQQAAQVASTGNLHHQLLLHMAANNSMLNTTDYYQQQQQES 487
            :|.|.||                 .|.:.|:...|....:          ...|..:...:|:.|
Human   373 QETPLKN-----------------TQDSPQIPDPGGDFQE----------PSGTQPFSSNEQEMS 410

  Fly   488 PSSAGQFMDDDLELLSLND-QQDKSDEPDHEMVTLADENAGLPGYQGNEAEATP-AQEDSP---- 546
            |:.. :...|......|.| ....|..|||.:|.             :|.|::| ..|..|
Human   411 PTRT-ELCQDSPMCTKLQDILVSASHSPDHPVVK-------------SEFESSPELVEKEPMLAI 461

  Fly   547 ------AAETATAPPPAPRSGKKGAKRPIQRRRVRRKAQSTLDDQAEHLTEMSVRGLDLFRYASV 605
                  |.:||....|.          ..:..|:...|.::   :.|.:.:..:.|.|:......
Human   462 DCREPYAFDTALLEQPC----------EAEEYRITSAAATS---ELEEILDFMLCGSDIEPPIGS 513

  Fly   606 VEG---------VYRCTECAKENMQKTFKNKYSFQRHAFLYHEGKHRKVFPCPVCSKEFSRPDKM 661
            :|.         .|..||..|.                  :.||            :|:..||
Human   514 LESPGAEGCRTPTYHLTETGKN------------------WIEG------------EEWCLPD-- 546

  Fly   662 KNHLKMTHENFTPPKDIGAFSPLKYLISAAAAGDMHATIYQQQQDHYHRQLAEQLEQQNASFDSR 726
                                                       .:.:.|:|.| ||::.|..:..
Human   547 -------------------------------------------MELWPRELTE-LEKEPAGENRG 567

  Fly   727 DSSLILPDVKMEHAEDQDAEQEAELSDGGYDASNPAAAAAAMLSLQQDVIIKDEIQISPSPSP-- 789
            .:.|:.|.|       ..:|....||.||....:....::..|..|:|.:    :.:|...:|
Human   568 PTELLSPLV-------MPSEVSEVLSVGGRWTPDLEITSSQPLDGQEDKL----LHVSSLDTPQR 621

  Fly   790 -----TPPASCAVAEGKSLALAS 807
                 :||.|..|..|..::|.:
Human   622 SYGDLSPPCSNWVETGLEVSLTT 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_001189329.1	BTB	23..119	CDD:279045	37/101 (37%)
		BTB	34..119	CDD:197585	32/87 (37%)
		C2H2 Zn finger	612..638	CDD:275370	3/25 (12%)
		zf-C2H2_4	646..669	CDD:290605	3/22 (14%)
		C2H2 Zn finger	648..669	CDD:275370	3/20 (15%)
BTBD18	NP_001138573.1	BTB	24..120	CDD:306997	34/95 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..176		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..355		32/184 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..410		9/62 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..676
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..712
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910