DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttk and zbtb20

DIOPT Version :9

Sequence 1:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_021331970.1	Gene:	zbtb20 / 568779	ZFINID:	ZDB-GENE-070112-1992	Length:	707	Species:	Danio rerio

Alignment Length:	764	Identity:	152/764 - (19%)
Similarity:	248/764 - (32%)	Gaps:	251/764 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYF-NTLFVSHPEKHPIVILKD 76
            :|..:::|...::..:...|.|||:.:.|..|:||:.||:|.||:| :.|.:.:.:   |.|...
Zfish    31 HNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD---IEIPSV 92

  Fly    77 VPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGAGA------ 135
            |....::.|:||||.|.:.|.|......|..|..|:||.:.:......|.....:|:|:
Zfish    93 VSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGISGSGSFSVVPG 157

  Fly   136 -TGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKRKRGRP 199
             :|.|:...||:.....|               :|.|.:|...|  ...|:.||
Zfish   158 DSGQETPRGTPESGTSGP---------------SSDAESGYMQT--SHQSVYSS----------- 194

  Fly   200 RKLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKMCNES-YSG-----NDDGSDDNQPNAGHTDDL 258
              |..|.:|.|                 |.||...|.| |:|     |.|
Zfish   195 --LYSSCSGLG-----------------LQNGTRGNRSHYAGAAVIANYD--------------- 225

  Fly   259 NESRDSLPSKRSKNSKDHRVVSHHEDNSTSVTPTKATPELSQRLFGSSSTTISATAPGGSSTGPS 323
                .:||.::.:..:|...::...:.|..:          :|...::.||.....|......|.
Zfish   226 ----SALPLQQKEAGQDPAWITRIHERSQQM----------ERFLSTTETTHCRKQPRPVRLHPG 276

  Fly   324 ETISLLEISDERESAPVHLPTILGLKIRAINTTTPAQQGSPQTPTKSKPKIRQATGSNNSNSL-- 386
            :               :|:....|.:..........:.|.|....:|:|| .::..|..|:|:
Zfish   277 D---------------IHIKQEQGDEFNCYGIEDCREDGEPLECVESEPK-GESFDSGVSSSIGT 325

  Fly   387 ----LKQQLRGGAKDPE--------VPPATRITGAVTPNAALNAEEQSKEMPKKNQDEVNACIGL 439
                ::|....|...|.        .|....:..:.........|:.|...|.:...|    ||:
Zfish   326 ETDSVEQPFLSGFNCPSKGQQGERGTPVQIEVNDSSPEQTQEIIEDSSGNGPTQESGE----IGI 386

  Fly   440 HSLANAAEQQAAQVAS-----------TGNLHHQLLLHMAANNSMLNTTDYYQQQQQESPSSAGQ 493
            |.    |...|.||..           |.||  ::.|.:.:|:.::.|              ||
Zfish   387 HQ----ANLTAPQVMPGGPYLRPGEPLTSNL--RMPLTLTSNSQVMGT--------------AG- 430

  Fly   494 FMDDDLELLSLNDQQDKSDEPDHEMVTLADENAGLP---GYQGNEAEATPAQEDSPAAETATAPP 555
                :..|.:|...|..||......        .||   |.|..:..|.|:....|.....:.||
Zfish   431 ----NTYLPTLFATQSASDNKPFLF--------SLPQSIGSQQPQFVAVPSPNMPPFPGGLSVPP 483

  Fly   556 -------PAPRSGKKGAKRPIQRRRVRRKAQSTLDDQAEHLTEMSVRGLDLFRYASVVEGVYRCT 613
                   .|| .|:.|.|:|                                         |.||
Zfish   484 GGSQQQGGAP-GGQHGEKKP-----------------------------------------YACT 506

  Fly   614 ECAKENMQKTFKNKYSFQRHAFLYHEGKHRKVFPCPVCSKEFSRPDKMKNHLKMTH--------- 669
            .|.     |||..|.::.:|.|: |.|:  |...|.:|.:.||..|.:..|: :||
Zfish   507 LCC-----KTFTAKQNYVKHMFV-HTGE--KPHQCSICWRSFSLKDYLIKHM-VTHTGVRAYQCS 562

  Fly   670 ---ENFTPPKDIGAFSPLKYLISAAAAGDMHATIYQQQQDHYHRQLAEQ 715
               :.||....:.....|.       .|:.....|..::...|:.|.|:
Zfish   563 ICNKRFTQKSSLNVHMRLH-------RGEKSYECYICKKKFSHKTLLER 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_001189329.1	BTB	23..119	CDD:279045	31/96 (32%)
		BTB	34..119	CDD:197585	30/85 (35%)
		C2H2 Zn finger	612..638	CDD:275370	9/25 (36%)
		zf-C2H2_4	646..669	CDD:290605	6/22 (27%)
		C2H2 Zn finger	648..669	CDD:275370	6/20 (30%)
zbtb20	XP_021331970.1	BTB	41..143	CDD:306997	32/104 (31%)
		C2H2 Zn finger	505..525	CDD:275368	9/25 (36%)
		zf-C2H2	531..553	CDD:306579	6/22 (27%)
		C2H2 Zn finger	533..553	CDD:275368	6/20 (30%)
		zf-H2C2_2	545..570	CDD:316026	4/25 (16%)
		zf-C2H2	559..581	CDD:306579	2/21 (10%)
		C2H2 Zn finger	561..581	CDD:275368	2/19 (11%)
		zf-H2C2_2	573..598	CDD:316026	3/31 (10%)
		C2H2 Zn finger	589..609	CDD:275368	4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910