DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttk and br

DIOPT Version :9

Sequence 1:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	1045	Identity:	219/1045 - (20%)
Similarity:	330/1045 - (31%)	Gaps:	427/1045 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SQRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKH 69
            :|.|||||||:||::.|.|:.|...|.|.|||||.||:.:|||::|||||||||..|..|.|.||
  Fly     4 TQHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCKH 68

  Fly    70 PIVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVN-DDKPSPAAAAAGA 133
            |:::|:||.:.|:.:|::|:|.|||:|.|:.|.:||:.||.||:.|||:.. :|..|..|.....
  Fly    69 PVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQIQNL 133

  Fly   134 GATGSESTATTPQLQRIQPYLVPQRNRSQAGG--LLASAANAGNTP--TLPVQPSLLSSALMP-- 192
            ..:|..:...|.......|:   ..:....||  .|.|...||:.|  .:|..||.:::.|:.
  Fly   134 ANSGGRTPLNTHTQSLPHPH---HGSLHDDGGSSTLFSRQGAGSPPPTAVPSLPSHINNQLLKRM 195

  Fly   193 -------------------KRKRGRPRKL-------SGSSNG----------------TGNDYDD 215
                               ||.||....|       |||:|.                |..|:..
  Fly   196 AMMHRSSAAAAAEETSHAFKRLRGSDNSLPLSGAVGSGSNNNSPDLPPLHARSASPQQTPADFST 260

  Fly   216 FDRENMMND--------SSDLGNGKMCNESYSGNDDGSDDNQPN--------------------A 252
            ....|..|.        :...|||.      |||.:|:.:...|                    |
  Fly   261 IKHHNNNNTPPLKEEKRNGPTGNGN------SGNGNGNGNGASNGNGISISDKLGSLTPSPLARA 319

  Fly   253 GHTDDLNESRDSLPSKRSKNSKDHR---VVSHHEDNSTS--------------------VTPTKA 294
            |..|..:|..|.:.|..:.|:.|..   ....|:.|.:|                    :....|
  Fly   320 GADDVKSEPMDMVCSNNNANANDEHSNDSTGEHDANRSSSGDGGKGSLSSGNDEEIGDGLASHHA 384

  Fly   295 TPEL-----SQRLF----------------------------------GSSSTTISAT-APGGSS 319
            .|:.     ..::|                                  ||:.:.:|.. .||||.
  Fly   385 APQFIMSPAENKMFHAAAFNFPNIDPSALLGLNTQLQQSGDLAVSPQGGSTGSLLSGVIVPGGSG 449

  Fly   320 TGPSETISLLEISD--------ERESAPVHLPTILGLKIRAINTTTPAQQGSPQTPTKSKPKIRQ 376
            ..||.:.|....::        |::|:|..|                .||....||..:.|:::|
  Fly   450 GTPSNSSSNNNNNNSNNQQQKVEQQSSPHQL----------------LQQQHHSTPHTNSPQLKQ 498

  Fly   377 -----------------ATGSNNSNSLLKQQLRGGAKDPEVPPATRITGAVTPNAALNAEEQSKE 424
                             |.||..|.|...|.:         |.|...:...:|.||.:..|:.:|
  Fly   499 EQPKSGGGSCKSSDLHIAAGSERSLSRSSQGM---------PDAGGHSATPSPTAAYHKRERERE 554

  Fly   425 ------------------------------------------------MPKKNQ-----DEVNAC 436
                                                            :|..:|     .|::|.
  Fly   555 RERERERERERERSLDHERDLERPGGTGSPPPPPPSHHSHFGQHPLSLLPSHHQLHATHHELSAA 619

  Fly   437 IGLHSLANAAEQQAAQVASTGN--LHHQLLLHMAANNSMLNTTDYYQQQQQESPSSAGQFMDDDL 499
            ...|:.|:|....|..:|..|:  .||.||.|..|:.|.....        .|.|.||.
  Fly   620 AAHHAHAHAHAAHAHALARAGSPMEHHHLLHHRRASLSPSGAV--------SSASGAGG------ 670

  Fly   500 ELLSLNDQQDKSDEPDHEMVTLADENAGLPGYQGNEAEATPAQEDSPAAETATAPPPAPRSGKKG 564
                                  ....||.||..|....::...:|...|.....|.|
  Fly   671 ----------------------RGGGAGGPGGPGGSLLSSVRAQDVAQANRLLLPLP-------- 705

  Fly   565 AKRPIQRRRVRRKAQSTLDDQAEHLTEMSVRGLDLFRYASVVEGVYRCTECAKENMQKTFKNKYS 629
                                                     :...:||..|.     |....|.:
  Fly   706 -----------------------------------------LNACHRCDVCG-----KLLSTKLT 724

  Fly   630 FQRHAFLYHEGKHRKVF---PCPVCSKEFSRPDKMKNHLKMTHENFTPPKDIGAFSPLKYLISAA 691
            .:||    .|.:|.:..   .|.:|.|.|...:.:.|
  Fly   725 LKRH----KEQQHLQPLNNAVCNLCHKVFRTLNSLNN---------------------------- 757

  Fly   692 AAGDMHATIYQQQQDHYHRQL------------AEQLEQQNASFDSRDSSLILPDVKMEHAEDQD 744
                 |.:||.::|.::|...            ..:|.|..:|..:..::
  Fly   758 -----HKSIYHRRQKNHHSYFHHGAGVSQAGSPGSRLHQSLSSLSAAAAA--------------- 802

  Fly   745 AEQEAELSDG--GYDASNPAAAAAAMLSLQQDVIIKDEIQISPSPSPTPPASCAVAEGKSLALAS 807
            |.....:..|  |....|..|||||..:...::::          ||...|: |||.|.:   :|
  Fly   803 ANNSVNVGGGSVGGAGGNAVAAAAAAAAAAAELLL----------SPIVGAA-AVAGGTA---SS 853

  Fly   808 TAQTA 812
            |.|.|
  Fly   854 TLQLA 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_001189329.1	BTB	23..119	CDD:279045	51/95 (54%)
		BTB	34..119	CDD:197585	47/84 (56%)
		C2H2 Zn finger	612..638	CDD:275370	6/25 (24%)
		zf-C2H2_4	646..669	CDD:290605	5/25 (20%)
		C2H2 Zn finger	648..669	CDD:275370	5/20 (25%)
br	NP_001162638.2	BTB	22..118	CDD:279045	51/95 (54%)
		BTB	33..118	CDD:197585	47/84 (56%)
		C2H2 Zn finger	712..729	CDD:275368	6/25 (24%)
		C2H2 Zn finger	742..763	CDD:275368	7/53 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020