DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttk and bab2

DIOPT Version :9

Sequence 1:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_523879.2	Gene:	bab2 / 44254	FlyBaseID:	FBgn0025525	Length:	1067	Species:	Drosophila melanogaster

Alignment Length:	823	Identity:	202/823 - (24%)
Similarity:	317/823 - (38%)	Gaps:	209/823 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHP 70
            |:|||||||:||||.:|||:||.:|:|.||||:.||..:||||||||||||||..||..:|.:||
  Fly   196 QQFCLRWNNYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHP 260

  Fly    71 IVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGAGA 135
            |:|::||.:||:|:|::|||:||::|.|:::...|:|||:|:|:||.||:..:....|:|....|
  Fly   261 IIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETLKIRGLAEVSAGRGEGGASALPMSA 325

  Fly   136 TGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPV-QPSLLSSALMPKRKRGRP 199
            ...|.               .:...:.|..:|....:|.....:.. :|.||...::...:|.|.
  Fly   326 FDDED---------------EEEELASATAILQQDGDADPDEEMKAKRPRLLPEGVLDLNQRQRK 375

  Fly   200 RKLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKM-CNESYSGNDDGSDDNQPNAGHTDDLNESRD 263
            |...||               ....|..|..|:. .:|..|....|...:||.|..|..:..:..
  Fly   376 RSRDGS---------------YATPSPSLQGGESEISERGSSGTPGQSQSQPLAMTTSTIVRNPF 425

  Fly   264 SLPSKRS---KNSKDHRVVSHHEDNSTSVTPTKATPELSQRLFGSSSTTISATAPGGSSTGPSET 325
            :.|:.::   :||..:.|.:..:    |..|| ||...:    |:|...:. :.|||.:.
  Fly   426 ASPNPQTLEGRNSAMNAVANQRK----SPAPT-ATGHSN----GNSGAAMH-SPPGGVAV----- 475

  Fly   326 ISLLEISDERESAPVHLPTILGLKIRAIN---TTTPAQQGSPQTPTKSKPKIRQATGSNNSNSLL 387
                     :.:.|.|:..|:.....|::   ....||.....:...:......|.|:..:.:
  Fly   476 ---------QSALPPHMAAIVPPPPSAMHHHAQQLAAQHQLAHSHAMASALAAAAAGAGAAGA-- 529

  Fly   388 KQQLRGGAKDPEVPPATRITGAV-----TPNAALNAEEQSKEMPKKNQDEVNACIGLHSLANAAE 447
                 |||.......|:..||..     ...||:.:.....|:..:..:.:.            |
  Fly   530 -----GGAGSGSGSGASAPTGGTGVAGSGAGAAVGSHHDDMEIKPEIAEMIR------------E 577

  Fly   448 QQAAQVASTGNLHHQLLLHMAANNSMLNTTDYYQQQQQE-------------------------- 486
            ::.|::..:|.....:....||..:.....|.||.|.|.
  Fly   578 EERAKMIESGGHGGWMGAAAAATGAASVAADSYQYQLQSMWQKCWNTNQQNLVQQLRFRERGPLK 642

  Fly   487 --SPSSAGQFMDDDL-ELLSLNDQQDKSDEPDHEMVTLADENAGLPGYQGNEAEATPAQEDSPAA 548
              .|.:..:.:...| |.|||:....|.|.|....|..|:....:.|               |:.
  Fly   643 SWRPEAMAEAIFSVLKEGLSLSQAARKFDIPYPTFVLYANRVHNMLG---------------PSL 692

  Fly   549 ETATAPPPAPRSGKKGAKRPIQRRRVRRKAQSTLDDQAEHLTEMSVRGL---DLFRYASVVEG-V 609
            :....|.|..|.      ||   :|:                   :.|:   :|.|  ||::. |
  Fly   693 DGGADPRPKARG------RP---QRI-------------------LLGMWPEELIR--SVIKAVV 727

  Fly   610 YRCTECAKENMQKTFKNKY-SFQRHAFLYHEGKHRKVFPCPVCSKEFSRPDKMKNHLKMTHENFT 673
            :|.....||:|.   .::| :.|.|......|.....:.....:|           |...:....
  Fly   728 FRDYREIKEDMS---AHQYANGQGHGTYIGGGTTTNGYHSAAAAK-----------LAAQNAALA 778

  Fly   674 PPKDIGAFSPLKYLISAAAAGDMHATIYQQQQDH--YHRQLAEQLEQQNASFDSRDSSLILPDVK 736
            || |.|  |||..:...     :...|..|||.|  :|:|.|.  .||..|...:.|
  Fly   779 PP-DAG--SPLSSMTET-----LRRQILSQQQQHQQHHQQQAH--HQQQPSHHQQQS-------- 825

  Fly   737 MEHAEDQDAE------QEAELSDGGYDASNPAAAAAAMLSLQQ 773
             .||:..:..      |.:|:.|   ..|..||.|||....||
  Fly   826 -PHAQSMNMYKSPAYLQRSEIED---QVSAAAAVAAAAAKHQQ 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_001189329.1	BTB	23..119	CDD:279045	54/95 (57%)
		BTB	34..119	CDD:197585	48/84 (57%)
		C2H2 Zn finger	612..638	CDD:275370	6/26 (23%)
		zf-C2H2_4	646..669	CDD:290605	2/22 (9%)
		C2H2 Zn finger	648..669	CDD:275370	2/20 (10%)
bab2	NP_523879.2	BTB	213..309	CDD:279045	54/95 (57%)
		BTB	224..309	CDD:197585	48/84 (57%)
		HTH_psq	645..690	CDD:283007	12/59 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010