DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttk and CG6118

DIOPT Version :9

Sequence 1:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001097806.1	Gene:	CG6118 / 41884	FlyBaseID:	FBgn0038339	Length:	967	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	145/583 - (24%)
Similarity:	219/583 - (37%)	Gaps:	174/583 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHPI 71
            ::.|.|||...|:...|..|...|...|||:|..|:..||||:|||.|||||..:|:.:|..|||
  Fly   392 QYLLSWNNFHGNMCRGFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENPSSHPI 456

  Fly    72 VILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGL-TEVN-----DDKPSP---- 126
            :::.||..|.|..||||||.|:|:|..|.|..||:|||:::|||| ||.|     .|..||
  Fly   457 LLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFLKVAEAMKIKGLHTEKNLDSDASDISSPHESD 521

  Fly   127 ----------------AAAAAG-AGATGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAG 174
                            :..||| .||..|:.::.:|.|..      |.|..:.     .|:..:|
  Fly   522 GTECRYERGTHSVNITSGHAAGYGGAPSSQQSSPSPSLNG------PNRCPTP-----LSSGGSG 575

  Fly   175 NTPTLPVQPSLLSSA-----LMPKRKRGRPRKLS-------GSSNGTGN----DYDDF------- 216
            |......:..:.|.|     .|....|......|       |.|||:.|    |.:.|
  Fly   576 NPNYAGFREHIKSKATLAETFMKNLNRNNNNNNSSNNYNHLGGSNGSLNLTEADSNSFAILQANS 640

  Fly   217 ---------------DRENMMNDSSDLGNGKMCNESYSGNDDGSDDNQPNA-GHTDDLN----ES 261
                           .|:.:|:.:::||..|...|.       ..|..|:| .|.|.||    .:
  Fly   641 KKMLDSARKQHKYLAKRKILMHYNTELGGEKRLKEM-------ERDRYPSAEQHDDALNNNHSHA 698

  Fly   262 RDSL--------------PSKRSKNSKDHRVVSHHEDNSTSVTPTKATPELSQRLFGSSSTTISA 312
            :|::              ||..:.|.|...|.|||..|:::....:           ||:...|:
  Fly   699 QDNIMEPIITTIVPQTPPPSTHNNNFKIRLVESHHLTNNSNNNQNQ-----------SSNNNNSS 752

  Fly   313 TAP-GGSSTGPSETISLLEI-----SDERESAP---VHLPTILGLKIRAINTTTPAQQGSPQTPT 368
            ::| ........|.::|::|     |..||:.|   ...|.|..:|.......:||:..|
  Fly   753 SSPQSNDCNNDEEALNLVQIPNANGSRNREATPTCATPTPDIQLIKREVKTELSPAENLS----- 812

  Fly   369 KSKPKIRQATGSNNSNSLLKQQLRGGAKDPEVPPATRITGAVTPNAALNAEEQSKEMPKK----N 429
                       :||.:.   .::.|...|.:......       |:.|:.|..|.....|    |
  Fly   813 -----------NNNGHD---DEMAGAGFDRKYDDNNN-------NSGLDMETDSNNNNSKPGGDN 856

  Fly   430 QDEVNACIGLHSLANAAEQQAAQVASTGNLHHQLLLHMAANNSMLNTTDYYQQQQQESPSSAG 492
            .:.:...:|.|.|.:|..:...|                      :..|:..|.||:..:..|
  Fly   857 NNGLALALGKHKLLSAINRNIEQ----------------------DHPDHEHQDQQDREADHG 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_001189329.1	BTB	23..119	CDD:279045	50/96 (52%)
		BTB	34..119	CDD:197585	47/85 (55%)
		C2H2 Zn finger	612..638	CDD:275370
		zf-C2H2_4	646..669	CDD:290605
		C2H2 Zn finger	648..669	CDD:275370
CG6118	NP_001097806.1	Myb_DNA-bind_4	20..97	CDD:290549
		BTB	408..508	CDD:279045	52/99 (53%)
		BTB	419..510	CDD:197585	49/90 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020