DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttk and bab1

DIOPT Version :9

Sequence 1:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_728565.1	Gene:	bab1 / 38116	FlyBaseID:	FBgn0004870	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	966	Identity:	215/966 - (22%)
Similarity:	338/966 - (34%)	Gaps:	350/966 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ASQRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEK 68
            :||:|||||||:|:||.::|||||..|.|.|||||.:|:.:||||||||||||||.||....|.:
  Fly    98 SSQQFCLRWNNYQTNLTTIFDQLLQNECFVDVTLACDGRSMKAHKMVLSACSPYFQTLLAETPCQ 162

  Fly    69 HPIVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGA 133
            |||||::||.:||:|::::||||||::|.|:::...||:||.|:::||.:|...:.:.|||||.:
  Fly   163 HPIVIMRDVNWSDLKAIVEFMYRGEINVSQDQIGPLLRIAEMLKVRGLADVTHMEAATAAAAAAS 227

  Fly   134 G----ATGSESTATT-----------------------------PQLQRIQPYLVPQRNRSQAGG 165
            .    ::..|||:|:                             |...|:.| |..|:.|:....
  Fly   228 SERMPSSPKESTSTSRTEHDREREAEELLAFMQPEKKLRTSDWDPAELRLSP-LERQQGRNVRKR 291

  Fly   166 LLASAANAGNTPTLPVQPSLLSSALMPKRKRGRPRKLSGSSNGTGNDYDDFDRENMMNDSSDLGN 230
            ...||....|.   |..||.|||.:..:|.                :.:..:||...:
  Fly   292 RWPSADTIFNP---PAPPSPLSSLIAAERM----------------ELEQKERERQRD------- 330

  Fly   231 GKMCN--------ESYSGNDDGSDDNQPNAGHTDDLNESRDSLPSKRSKNSKDHR---------- 277
               |:        ...||:..|:......|.|..|: .|..:.|...|::|:.|.
  Fly   331 ---CSLMTPPPKPPMSSGSTVGATRRLETAIHALDM-PSPAATPGPLSRSSRPHSQSPQQQQAQQ 391

  Fly   278 ---------VVSHHEDNSTSVTPTKATPELSQRLFGSSSTTISATAPGGSS---TGPSETISLLE 330
                     :..||.        ....|..||    ::.:.....:|.|.|   .||:..::
  Fly   392 QGQLPLPLPLHPHHH--------ASPAPHPSQ----TAGSAHHPASPAGDSRFPLGPAAAMA--- 441

  Fly   331 ISDERESAPVHLPTILGLKIRAINTTTPAQQGSPQTPTKSKPKIRQ----------------ATG 379
                              ..|.::...|.....|:.|  ..|....                ..|
  Fly   442 ------------------AARELSGLGPGPSAEPRLP--PPPPHHHGGGGVGGGGVGGGGAGGVG 486

  Fly   380 SNNSNSLLKQQLRGGAKDPEVPPATRITGAVTPNAALNAEEQSKEMPKKNQDEVNACIGLHSLAN 444
            |...:||        |.|.|:.|...        ..:..||::|.|     :..:|.:|......
  Fly   487 SGGGSSL--------ADDLEIKPGIA--------EMIREEERAKMM-----ENSHAWMGATGSTL 530

  Fly   445 AAEQQAAQVAS----TGNLHHQLLLHMAANNSMLNTTDYYQQQQQES--PSSAGQFMDDDL-ELL 502
            ||:....|:.|    ..|.:..|:.||.          :.::...:|  |.:..:.:...| |.|
  Fly   531 AADSYQYQLQSMWQKCWNTNQNLMHHMR----------FRERGPLKSWRPETMAEAIFSVLKEGL 585

  Fly   503 SLNDQQDKSDEPDHEMVTLADENAGLPGYQGNEAEATPAQEDSPAAETATAPPPAPRSGKKGAKR 567
            ||:....|.|.|....|..|:....:.|         |:.:..|..                  |
  Fly   586 SLSQAARKYDIPYPTFVLYANRVHNMLG---------PSIDGGPDL------------------R 623

  Fly   568 PIQRRRVRRKAQSTLDDQAEHLTEMSVRGLDLFRYASVVEGVYRCTECAKENMQKTFKNKYSFQR 632
            |..|.|.:|.......|  ||     ::|:       :...|:|.|:..|:.         |...
  Fly   624 PKGRGRPQRILLGIWPD--EH-----IKGV-------IKTVVFRDTKDIKDE---------SLAA 665

  Fly   633 HAFLYHEGKHRKVFP-----------------------CP----------VCSKEFSRPDKMKNH 664
            |...|  |:|...||                       ||          |..::....:.....
  Fly   666 HMPPY--GRHSPAFPLQDLPLSYPGASGALAGAPSSMACPNGSGPQTGVGVAGEQHMSQETAAAV 728

  Fly   665 LKMTHE---------------NFTPPKDIG--------------AFSPLKYLISAAAAGDMHATI 700
            ..:.|.               |..|...:|              :.||    ..::.:|..||..
  Fly   729 AAVAHNIRQQMQMAAVPPGLFNLPPHPGVGGGVGNVPGAAGGRASISP----ALSSGSGPRHAPS 789

  Fly   701 --------------------YQQQQD--HYHRQLAEQLEQQNASFDSRDSSLILPDVKMEHAEDQ 743
                                :||||.  |:|.|.. .|:||.|              .:.|.:.|
  Fly   790 PCGPAGLLPNLPPSMAVALHHQQQQQAAHHHMQQL-HLQQQQA--------------HLHHHQQQ 839

  Fly   744 DAEQEAELSDG--------GYDASNPAAAAAAMLSLQQDVIIKDEIQISPSPSPTP 791
            ..:|:.:...|        |:.||:.::|:::.:....    ..:.:.||..|.||
  Fly   840 QQQQQQQHHQGGHQVAHKSGFGASSSSSASSSSMGQHH----APKAKSSPLRSETP 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_001189329.1	BTB	23..119	CDD:279045	55/95 (58%)
		BTB	34..119	CDD:197585	48/84 (57%)
		C2H2 Zn finger	612..638	CDD:275370	4/25 (16%)
		zf-C2H2_4	646..669	CDD:290605	5/55 (9%)
		C2H2 Zn finger	648..669	CDD:275370	3/30 (10%)
bab1	NP_728565.1	BTB	117..216	CDD:279045	56/98 (57%)
		BTB	128..213	CDD:197585	48/84 (57%)
		HTH_psq	569..614	CDD:283007	12/53 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010