DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttk and ab

DIOPT Version :9

Sequence 1:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	855	Identity:	207/855 - (24%)
Similarity:	304/855 - (35%)	Gaps:	238/855 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHP 70
            |.:.|:||:.||::||.|..|...|.|.|||||.:.:...|||:|||||||||..|..::|.:||
  Fly    76 QHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHP 140

  Fly    71 IVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGAGA 135
            ||||:||...|:::||.|||.|||:|..|:|..||:.|..|:|:||.:||...|...|.:|....
  Fly   141 IVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKALSAALSH 205

  Fly   136 TGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKRKRGRPR 200
            ..|.:                ..|.|.:...|::..|..|........:.:||.|       .|.
  Fly   206 NSSNN----------------NNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYL-------SPN 247

  Fly   201 KLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKMCNESYSGNDDGSDDNQPNAGHTDDLNESRDSL 265
            :.|.:.|.:.|       .|..|.||.      .|.|.|.|..||            ||.|.:|
  Fly   248 QTSAACNNSSN-------SNSNNHSSS------HNNSSSNNISGS------------LNSSLNS- 286

  Fly   266 PSKRSKNSKDHRVVSHHEDNSTSVTPTKATPELSQRLFGSSSTTISATAPGGSSTGPSETISLLE 330
                              ..|....|...|...:.....::::..:|.|...::|..|...|...
  Fly   287 ------------------PFSAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSSSSA 333

  Fly   331 ISDERESAPVHLPTILGLKIRAINTTTPAQQGSPQTPTKSKPKIRQATGSNNSNSLLKQQLRGGA 395
            .|.:....|..      .:::|.:..:|.:..:| .|:|          :::||.....::.|..
  Fly   334 ASGQTSGTPAI------QELKASSAASPVRNPNP-NPSK----------ASSSNHWDMGEMEGSR 381

  Fly   396 KD---PEVPPATRITGA--------VTPNAALNAEEQSKEMPKKNQDEVNACIGLHSLANAAEQQ 449
            |.   |  ||..||..|        ::|...|    ..:|.|         ..|.|.|......:
  Fly   382 KSHLTP--PPQKRIKSADLFRAQHGISPERLL----LDREFP---------VAGQHPLTRNRSGR 431

  Fly   450 AAQVASTGNLH-HQLLLHMAANNSMLNTTDYYQQQQQESPS-SAGQFMDDDLELLSLNDQQDKSD 512
            ........||. .:.||..|..||         ..||.:|. ..||...:|    |.:...:.||
  Fly   432 DTSKDRERNLELRESLLGQALENS---------NGQQANPKHELGQSAGED----SNSSDTEPSD 483

  Fly   513 EPD--HEMVTLADEN----------AGLPGYQGNEAEATPAQEDSPAAET------ATAPPPAPR 559
            ..|  |:......:|          .||.|..|.....:....|..:..:      ||.|.|.|:
  Fly   484 RGDGQHDGTLDGIDNQRSHSFPNAFLGLQGIPGLLPGPSGINSDFVSRRSLEMRVRATDPRPCPK 548

  Fly   560 SGKKGAKRPIQRRRVRRKAQSTLDDQAEHLTEMSVRGLDLFRYASVVEGVYRCTECAKENMQKTF 624
            .||           :.|.|.:.    ..||.:..          :|..| |||..|.     ...
  Fly   549 CGK-----------IYRSAHTL----RTHLEDKH----------TVCPG-YRCVLCG-----TVA 582

  Fly   625 KNKYSFQRHAFLYHEG---KHRKVFPCP-VCSKEFSRPDKMKNHLKMTHENFTPPKDI------- 678
            |::.|...|....|.|   |...|.|.| ....|.:.....|..:|::      |.::
  Fly   583 KSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDPELASRLLAKAGVKIS------PAELRARASPT 641

  Fly   679 -----------GAFSPLKYLISAAAAGDMHATIYQQQQDHYHRQLAEQLEQQNASFDSRDSSLIL 732
                       |..|..|..:|.|:.|.|...  :...|.     .|.|...|..:....||
  Fly   642 GGSGSSGGGGGGGSSQAKLDLSNASGGPMDDA--EDSDDD-----PEDLTTGNGLYGMGGSS--- 696

  Fly   733 PDVKMEHAEDQDAEQEAELSDGGY----DASNPAAAAAAMLSLQQDVIIKDEIQISPSPSPTPPA 793
            .|:...|        |:.||:.|:    :.:...||.||.|...:|:    .:|:..|.:|
  Fly   697 SDLSRYH--------ESLLSNFGHARMRNEAAAVAATAAALGQPKDL----GVQLPNSNAP---- 745

  Fly   794 SCAVAEGKSL 803
                  |:||
  Fly   746 ------GQSL 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_001189329.1	BTB	23..119	CDD:279045	50/95 (53%)
		BTB	34..119	CDD:197585	46/84 (55%)
		C2H2 Zn finger	612..638	CDD:275370	5/25 (20%)
		zf-C2H2_4	646..669	CDD:290605	5/23 (22%)
		C2H2 Zn finger	648..669	CDD:275370	4/21 (19%)
ab	NP_476562.1	BTB	93..189	CDD:279045	50/95 (53%)
		BTB	104..189	CDD:197585	46/84 (55%)
		zf-Di19	545..597	CDD:283297	17/82 (21%)
		C2H2 Zn finger	546..567	CDD:275371	7/35 (20%)
		C2H2 Zn finger	575..596	CDD:275371	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020