DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttk and chinmo

DIOPT Version :9

Sequence 1:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001188680.1	Gene:	chinmo / 33343	FlyBaseID:	FBgn0086758	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	967	Identity:	204/967 - (21%)
Similarity:	313/967 - (32%)	Gaps:	349/967 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHP 70
            |:|||:||:..|||...|..|..::...||.|:.:|...||||::|:|||..|..||.:.|....
  Fly     5 QQFCLKWNSFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQ 69

  Fly    71 IVILKDVPYSD-MKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLT-------------EVND 121
            .||:.:....| |.:||:|||:|||.|.||.|.:||:.||||::|||:             .:.|
  Fly    70 CVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAESLQVKGLSTETGRLAAQQAQQHMGD 134

  Fly   122 DKP--SPAAAAA---------------------GAGATGSESTA-----TTPQLQRIQPYLVPQR 158
            ..|  ||....:                     |.||||:.|.:     ....|..:
  Fly   135 LSPLDSPTGRRSVRNSLSGGSSSIVPGGVGIGLGGGATGANSMSGMGIGNGLSLAGM-------- 191

  Fly   159 NRSQAGGLLASAAN--AGNTPTLPVQPSLLSSALMPKRKRGRPRKLSGSSNGTGNDYDDFDRENM 221
               .|||.:|:|||  |.:..||..     |:.::.:........:|||:.|.|..:
  Fly   192 ---AAGGGMAAAANAAASSLSTLAA-----SANIVDRCGSAGANIISGSAAGIGGSH-------- 240

  Fly   222 MNDSSDLGNGKMCNESYSGNDDGSDDNQPNAGHTDDLNESRDSLPSKRSKNSKDHRVVSHHEDNS 286
               |...|||. ......||..||...          |....||.|...        .:||...|
  Fly   241 ---SGGAGNGS-GTVGIGGNGVGSGGG----------NNGPISLGSGAG--------AAHHLGGS 283

  Fly   287 TSVTPTKATPELSQRLFGSSSTTISATAPGG--SSTGPSETISLLEISDERESAPVHLPTILGLK 349
            |.:...:..               |...|||  ||:|...|               |:|.|
  Fly   284 TGILKQECD---------------SLMHPGGSSSSSGMGYT---------------HVPPI---- 314

  Fly   350 IRAINTTTPAQQGSPQTPTKSKPKIRQATGSNNSNSLLKQQLRGGAKDPEV------PPATRITG 408
            .|.||...|.::...::|...    ::..||         .||.|:|..|.      ||..|.:.
  Fly   315 YRPINYEPPRKRAIVRSPYSE----QEQRGS---------VLRDGSKSSECPSPINKPPYHRPSS 366

  Fly   409 AVTPNAALNAEEQSKE--MPKKNQDEVNACIGLHSLANAAEQQAAQVASTGNLHHQLLLHMAANN 471
            :.:..|...|:....|  .|:.::.|              ....:..|..||          |.:
  Fly   367 SASSTAPTEADTMHSERASPQSSRYE--------------NHSPSTTAGNGN----------ATS 407

  Fly   472 SMLNTTDYYQQQQQESPSSAGQFMDDDLELLSLNDQQDKSDEPDHEMVTLADENAGLPGYQGNEA 536
            |:....     :.:.:..||.:..|||.||:      |:|.:...|.:.:..||
  Fly   408 SLERIV-----KSERNNGSANEANDDDRELM------DESTDNGAEDLRVKLEN----------- 450

  Fly   537 EATPAQEDSPAAETATAPPPAPRSGKKGAKRPIQRRRVRRKAQSTLDDQAEHLTEMSVRGLDLFR 601
                         ...:|||.|.|.............:  ||..||...    ...|:...|:.
  Fly   451 -------------LKYSPPPPPNSNTSSTTPNTLLENL--KADGTLSSN----LAASIAPADML- 495

  Fly   602 YASVVEGVYRCTECAKENMQKTFKNK----------YSFQRHAFLYHEGKHRKV-FPCPVCSKEF 655
                  .|:..|:...:|...|...|          |.::.:...:...:|:.: .|||.|.:.|
  Fly   496 ------NVWNATKMNNKNSVNTADGKKLKCLYCDRLYGYETNLRAHIRQRHQGIRVPCPFCERTF 554

  Fly   656 SRPDKMKNHLKMTHEN--------FTPPKDIGA--------------FSPLKYLISAAAAGDMHA 698
            :|.:.::.|:...|:.        ...|..:.|              .||.:...:|||:..|:|
  Fly   555 TRNNTVRRHIAREHKQEIGLAAGATIAPAHLAAAAAASAAATAAASNHSPXEAAATAAASVVMNA 619

  Fly   699 T---------------------------------------------------------------- 699
            .
  Fly   620 NKEAAKQRKRKTLKMALEKCMQRRDAMVAETTTGAGGDGAEAGGESGEAVDGAGSEEGAGSEGTE 684

  Fly   700 --IYQQQQDHYHRQLAEQL------EQQNASFDSRDSSLILPDVKMEHAED-----QDAEQEAEL 751
              .|:|||...|::|.:|:      ||...:.||..::.:..........:     .|...:||.
  Fly   685 PLTYEQQQQRMHQELTQQIRAAMAAEQAAEAMDSTMNTTVNTTTTTTTTTNTTGATSDGCSDAEA 749

  Fly   752 SDGGYDASNPAAAAAAMLSLQQDVIIKDEIQISPSPSPTPPASCAVAEGKSLALAST 808
            |||   :..|.                 |:.....|.|.|.:...|.|.|...|:.:
  Fly   750 SDG---SDRPM-----------------EVDEDQPPEPQPGSELVVVEPKIEVLSES 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_001189329.1	BTB	23..119	CDD:279045	43/109 (39%)
		BTB	34..119	CDD:197585	41/98 (42%)
		C2H2 Zn finger	612..638	CDD:275370	5/35 (14%)
		zf-C2H2_4	646..669	CDD:290605	7/22 (32%)
		C2H2 Zn finger	648..669	CDD:275370	6/20 (30%)
chinmo	NP_001188680.1	BTB	22..116	CDD:279045	41/93 (44%)
		BTB	33..116	CDD:197585	39/82 (48%)
		C2H2 Zn finger	519..540	CDD:275368	1/20 (5%)
		C2H2 Zn finger	547..568	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020