Protein Alignment ttk and br

DIOPT Version :10

• Sequence 1: NP_733443.1
• Gene: ttk / 48317
• FlyBaseID: FBgn0003870
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_061497249.1
• Gene: br / 3290570
• VectorBaseID: AGAMI1_003202
• Length: 688
• Species: Anopheles gambiae
• Alignment Length: 836
• Identity: 190/836 - (22%)
• Similarity: 290/836 - (34%)
• Gaps: 276/836 - (33%)

  Fly     5 SQRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKH 69
            :|.|||||||:||::.|.|:.|...|.|.|||||.:|:.||||::||||||.||..|..|.|.||
Mosquito     4 TQHFCLRWNNYQSSITSAFENLRDDEDFVDVTLACDGRSLKAHRVVLSACSTYFRELLKSTPCKH 68

  Fly    70 PIVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGAG 134
            |:::|:||.::|:.:|::|:|.|||:|.|..|::||:.||.||:.|||:...::.....|:.||.
Mosquito    69 PVIVLQDVAFTDLHALVEFIYHGEVNVHQRSLSSFLKTAEILRVSGLTQQQAEETHGMHASLGAN 133

  Fly   135 ATG-------------------SESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLP 180
            ...                   |:..:..|.|..:.....|     .:||:....:|.|..|.:.
Mosquito   134 LPSGVVHHPIYPEKMLDDSLYVSQGASPPPHLSSLHNSSSP-----NSGGVGGGNSNGGGAPMVN 193

  Fly   181 VQPSLLSSALMPKRKRG----------RPRKLSGSSNGTGNDYDDFD------RENMMNDSSDLG 229
            ......::|...:|:|.          :..::|..|||..|..|..|      :....:.||...
Mosquito   194 QLLKRAAAAAALRRERNNSVHSDEMALKRHRMSVDSNGPTNPRDHLDVICSTPQTTATDFSSSAA 258

  Fly   230 NGKMCNESYSGNDDGSDDNQPNAGHTDDLNESRDSLPSKRSKNSKDHRVVSHHEDNSTSVTPTKA 294
            ...:...|..|.|        .....|.|:...:|..:..|.||..:.:.|...:|:.::....
Mosquito   259 KQHLSLPSPQGKD--------QMRQQDSLSGHANSGSNSFSINSASNLIKSSINNNNNNINNNN- 314

  Fly   295 TPELSQRLFGSSSTTISATAPGGS----STGPSETISLLEISDERESAPVHLPTILGLKIRAINT 355
              .|:..|..|...  |....||:    .:|.|                  :||.||       |
Mosquito   315 --NLNNNLLHSKEN--SGVGGGGAGGLCGSGGS------------------MPTSLG-------T 350

  Fly   356 TTPAQQGSPQTPTK----SKPKIRQA-------------TGSNNSNS----------LLKQQL-- 391
            :..:..||..:..|    |.|..|.|             ||.::.||          |:|..|
Mosquito   351 SNGSNAGSLCSAEKESLASSPSERSAEDVKSEPLELLCGTGGDHENSSDSVTDDHGDLVKGGLDV 415

  Fly   392 RGGAKDPEVPPATRITGAVTPNAALNAEEQSKEMPKKNQDEVNACIGLHS----LANAAEQQAAQ 452
            :|..:.|                              |..|:.:.:..||    |.||:|.:...
Mosquito   416 KGSLRSP------------------------------NDHELESSMHHHSGAQFLMNASENKLFP 450

  Fly   453 VASTGNLHHQLLLHMAANNSMLNTTDYYQQQQQESPSSAGQFMDDDLELLSLNDQQDKSDEPDHE 517
            ...:.|..   :..:||:                 ||:...|....|:.:.|
Mosquito   451 TPPSFNFS---MAALAAD-----------------PSALAGFSTQALQAVEL------------- 482

  Fly   518 MVTLADENAGLPGYQGNEAEATPAQEDSPAAETATAPPPAPRSGKKGAKRPIQRRRVRRKAQSTL 582
                    ||.|  ||....|      |.||...:|.||....|..|....:.
Mosquito   483 --------AGSP--QGMSIAA------SMAASQRSASPPDGGGGGGGGGSSVH------------ 519

  Fly   583 DDQAEHLTEMSVRGLDLFRYASVVEGVYRCTECAKENMQKTFKNKYSFQRHAFLYHEGKHRKVF- 646
                      ...|::.......:...:||..|.     |....|.:.:||    .|.:|.:..
Mosquito   520 ----------GGHGMNRLSLPLPLAACHRCDVCG-----KLLSTKLTLKRH----KEQQHLQPLN 565

  Fly   647 --PCPVCSKEFSRPDKMKNHLKMTHE-----------NFTP-----PKDI--------------- 678
              .|.:|.|.|...:.:.||..:.|.           :..|     |..:
Mosquito   566 NAVCNLCHKVFRTLNSLNNHKSIYHRRQKILHHHHHAHHHPLHGQHPFAVGGGPGAGGPGGGGGG 630

  Fly   679 GAFSPLKY------------LISAAAAGDMHATIYQQQQ-----DHYHRQLAEQLE 717
            ||.|||.:            ..:|||||..|..:.....     |..|..:|.:||
Mosquito   631 GAVSPLHHGAAHAAVTAAAVAAAAAAAGGHHELLNNNAAGATDCDIKHNSVAAKLE 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_733443.1	BTB_POZ_BAB-like	32..115	CDD:349624	44/82 (54%)
		PTZ00112	<184..>309	CDD:240274	26/140 (19%)
		C2H2 Zn finger	612..638	CDD:275370	6/25 (24%)
		zf-C2H2_4	646..669	CDD:464025	6/25 (24%)
		C2H2 Zn finger	648..669	CDD:275370	6/20 (30%)
br	XP_061497249.1	None