DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttk and Zbtb24

DIOPT Version :9

Sequence 1:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_700447.2	Gene:	Zbtb24 / 268294	MGIID:	3039618	Length:	710	Species:	Mus musculus

Alignment Length:	913	Identity:	176/913 - (19%)
Similarity:	262/913 - (28%)	Gaps:	375/913 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPE-KHPIVILKD 76
            :.|...:|:..:.........|:||.||..|.:|||.:|:|.|.||:.:|....| ...|.:|:.
Mouse    17 DTHSDTVLASLEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEG 81

  Fly    77 VPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEV------NDDKPSPAAAAAGAGA 135
            :.......||:|:|.|.:...::.....|..|:.|::..|.:.      |...|.|.|    ...
Mouse    82 MVADTFGILLEFIYTGYLHASEKTTEQILATAQFLKVYDLVKAYADFQDNHSAPKPPA----LNC 142

  Fly   136 TGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKRKRGRPR 200
            ||:             |.:|              .:|..|.|.              ||||||||
Mouse   143 TGT-------------PVVV--------------ISNKKNDPL--------------KRKRGRPR 166

  Fly   201 KLSGSSNG-------------TGNDYDD-----FDRENMMNDSSDLGNGKMCNESYSGNDDGS-- 245
            |.:|...|             ..|...:     |..|:.:..|......|   ||....:.||
Mouse   167 KANGLQEGRSELAAEGELQLRVNNSVQNRQNFVFKEEDSVKLSEQTPEDK---ESEPAGEPGSVE 228

  Fly   246 ------DDN-QPNAGHTDDLNESRDSLPSKRSKNS---KDHRVVSHHEDNSTSVTPTKATPELSQ 300
                  |:| .|.||   |..||:.....:|.:.|   ||::::...:|.||           ::
Mouse   229 EVPAEKDENFDPKAG---DGQESQSRCSRRRIRRSVKLKDYKLLGDEDDQST-----------AK 279

  Fly   301 RLFGSSSTTISATAPGGSSTGPSETISLLEISDERESAPVHLPTILGLKIRAINTTTPAQQGSPQ 365
            ||.|...                                                    :...|:
Mouse   280 RLCGRKK----------------------------------------------------RSSGPE 292

  Fly   366 TPTKSKPKIRQATGSNNSNSLLKQQLRGGAKDPEVPPATRITGAVTPNAALNAEEQSKEMPKKNQ 430
            ...|...::     ...|:.|...|.|...:.|                 ....|..|...:|:.
Mouse   293 ARCKDCDRV-----FKYSHFLAIHQRRHTGERP-----------------FKCNECGKGFAQKHS 335

  Fly   431 DEVNACIGLHSLANAAEQQ-----AAQVASTGNLHHQLLLHMAANNSMLNTT-----DYYQQQQQ 485
            .:|      |:..:..|:.     ..:..:|   .|.||.||:.::...:.|     .|:.|::|
Mouse   336 LQV------HTRMHTGERPYTCTVCGKALTT---KHSLLEHMSLHSGQKSFTCDQCGKYFSQKRQ 391

  Fly   486 --------------ESPSSAGQFMDDDLELLSLNDQQDKSDEPDHEMVTLADENAGLPGYQGNEA 536
                          |......:|||         ..|.|.....|
Mouse   392 LKSHYRVHTGHSLPECSHCHRKFMD---------VSQLKKHLRTH-------------------- 427

  Fly   537 EATPAQEDSPAAETATAPPPAPRSGKK-GAKRPIQRR-RVRRKAQSTLDDQAEHLTEMSVRGLDL 599
                         |...|......||. .||..:|.. |:.|.
Mouse   428 -------------TGEKPFTCEICGKSFTAKSSLQTHIRIHRG---------------------- 457

  Fly   600 FRYASVVEGVYRCTECAKENMQKTFKNKYSFQRHAFLYHEGKHRKVFPCPVCSKEFSRPDKMKNH 664
                   |..|.|:.|.     |.|.:..:.:||..| |.||  |.|.||.|..:|:|.|.:|.|
Mouse   458 -------EKPYSCSICG-----KCFSDSSAKRRHCIL-HTGK--KPFSCPECGLQFARLDNLKAH 507

  Fly   665 LKM-----------------------------------------------THE-NFTP-PKD--- 677
            ||:                                               .|. ||.| |..
Mouse   508 LKIHSKEKHTADSSSVSGSNVDEGRNILQLQPYQLSTSGEQEIQLLVTDSVHNINFMPGPSQGVS 572

  Fly   678 -IGAFSPLKYLISAAAAGDMHATIYQQQQDHY-------HRQLAEQLEQQNASFDSRDSSLILP- 733
             :.|.||.......||    :.|:..||.:..       .::.||.::..:......:||...|
Mouse   573 IVAAESPQSMATDPAA----NITLLTQQPEQLQGLILSAQQEQAEHIQSLSVIGGQMESSQTEPV 633

  Fly   734 ---DVKMEHAEDQDAEQEAELSDGGYDASNPAAAAAAMLSLQQDVIIKDEIQISPSPSPTPPASC 795
               .:..|..|...|.||...|      |.|||...|              :.:|.||..|.|..
Mouse   634 HVITLSKETLEHLHAHQEQTTS------SVPAADTGA--------------RATPVPSTRPGAEL 678

  Fly   796 AVA 798
            ..|
Mouse   679 TQA 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_001189329.1	BTB	23..119	CDD:279045	27/96 (28%)
		BTB	34..119	CDD:197585	27/85 (32%)
		C2H2 Zn finger	612..638	CDD:275370	7/25 (28%)
		zf-C2H2_4	646..669	CDD:290605	11/69 (16%)
		C2H2 Zn finger	648..669	CDD:275370	10/67 (15%)
Zbtb24	NP_700447.2	BTB	27..128	CDD:279045	27/100 (27%)
		BTB	38..133	CDD:197585	28/94 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..176		21/86 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..256		15/59 (25%)
		C2H2 Zn finger	295..315	CDD:275368	4/24 (17%)
		zf-H2C2_2	308..332	CDD:290200	6/40 (15%)
		COG5048	<320..479	CDD:227381	39/260 (15%)
		C2H2 Zn finger	323..343	CDD:275368	5/25 (20%)
		zf-H2C2_2	335..360	CDD:290200	3/30 (10%)
		C2H2 Zn finger	351..371	CDD:275368	6/22 (27%)
		zf-H2C2_2	363..388	CDD:290200	6/24 (25%)
		C2H2 Zn finger	379..399	CDD:275368	3/19 (16%)
		COG5048	406..>563	CDD:227381	41/235 (17%)
		C2H2 Zn finger	407..427	CDD:275368	5/28 (18%)
		zf-H2C2_2	420..443	CDD:290200	6/55 (11%)
		C2H2 Zn finger	435..455	CDD:275368	6/19 (32%)
		zf-H2C2_2	447..471	CDD:290200	8/57 (14%)
		C2H2 Zn finger	463..479	CDD:275368	4/20 (20%)
		zf-H2C2_2	477..500	CDD:290200	12/25 (48%)
		C2H2 Zn finger	491..511	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..676		11/44 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910