DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttk and ZBTB9

DIOPT Version :9

Sequence 1:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_689948.1	Gene:	ZBTB9 / 221504	HGNCID:	28323	Length:	473	Species:	Homo sapiens

Alignment Length:	666	Identity:	128/666 - (19%)
Similarity:	190/666 - (28%)	Gaps:	263/666 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHPIVIL 74
            :.:..|.|:||...::......|.||:|.|:|:.|:|||.||:|.||||          |..::|
Human    25 IEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYF----------HDKLLL 79

  Fly    75 KDVPYSDMKS---------LLDFMYRGEVSVDQERLTAFLRVAESLRI-KGLTEVNDDKPSPAAA 129
            .|.|...:.|         ||..:|.|.:.:..:.|.|.|.||..|:: :.:.:.::.......:
Human    80 GDAPRLTLPSVIEADAFEGLLQLIYSGRLRLPLDALPAHLLVASGLQMWQVVDQCSEILRELETS 144

  Fly   130 AAGAGATGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKR 194
            ..|..|.|..|            |.......|..||....::        |.|..:.|||
Human   145 GGGISARGGNS------------YHALLSTTSSTGGWCIRSS--------PFQTPVQSSA----- 184

  Fly   195 KRGRPRKLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKMCNESYSGNDDGSDDNQPNAGHTDDLN 259
            ....|........|.|               |:||............::..||::.....|
Human   185 STESPASTESPVGGEG---------------SELGEVLQIQVEEEEEEEEDDDDEDQGSAT---- 230

  Fly   260 ESRDSLPSKRSKNSKDHRVVSHHEDNSTSVTPTKATPELSQRLFGSSSTTISATAPGGSSTGPSE 324
                     .|:..:..||        :.|.|         |..|.....::||        |.:
Human   231 ---------LSQTPQPQRV--------SGVFP---------RPHGPHPLPMTAT--------PRK 261

  Fly   325 TISLLEISDERESAPVHLPTILGLKIRAINTTTPAQQGSPQTPTKSKPKIRQATGSNNSNSLLKQ 389
            .       .|.||||:.||                      .|....|||          ..:||
Human   262 L-------PEGESAPLELP----------------------APPALPPKI----------FYIKQ 287

  Fly   390 QLRGGAKDPEVPPATRITGAVTPNAALNAEEQSKEMPKKNQDEVNACIGLHSLANAAEQQAAQVA 454
            :        ...|...|:|:.|...  .|:|::|                             |.
Human   288 E--------PFEPKEEISGSGTQPG--GAKEETK-----------------------------VF 313

  Fly   455 STGNLHHQLLLHMAANNSMLNTTDYYQQQQQESPSSAG---QFMDDDL---ELLSLNDQQDKSDE 513
            |.|:         ...|..|.    :.......|:|.|   .:...||   |:||
Human   314 SGGD---------TEGNGELG----FLLPSGPGPTSGGGGPSWKPVDLHGNEILS---------- 355

  Fly   514 PDHEMVTLADENAGLPGYQGNEAEATPAQEDSPAAETATAPPPAPR----SGKKGAKRPIQRRRV 574
                       ..|.||..|....       .|.....|.|....|    .||:.|.:|.:.|.:
Human   356 -----------GGGGPGGAGQAVH-------GPVKLGGTPPADGKRFGCLCGKRFAVKPKRDRHI 402

  Fly   575 RRKAQSTLDDQAEHLTEMSVRGLDLFRYASVVEGVYRCTECAKENMQKTFKNKYSFQRHAFLYHE 639
                          :...|:|             .:.|..|     .|.||.|:....|...:..
Human   403 --------------MLTFSLR-------------PFGCGIC-----NKRFKLKHHLTEHMKTHAG 435

  Fly   640 GKHRKVFPCPVCSKEF 655
            ..|    .||.|.:.|
Human   436 ALH----ACPHCGRRF 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_001189329.1	BTB	23..119	CDD:279045	32/105 (30%)
		BTB	34..119	CDD:197585	31/94 (33%)
		C2H2 Zn finger	612..638	CDD:275370	7/25 (28%)
		zf-C2H2_4	646..669	CDD:290605	4/10 (40%)
		C2H2 Zn finger	648..669	CDD:275370	4/8 (50%)
ZBTB9	NP_689948.1	BTB	38..140	CDD:306997	32/111 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..279		31/188 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..376		24/154 (16%)
		C2H2 Zn finger	388..405	CDD:275368	5/30 (17%)
		C2H2 Zn finger	413..433	CDD:275368	7/24 (29%)
		zf-C2H2	413..433	CDD:306579	7/24 (29%)
		C2H2 Zn finger	440..457	CDD:275368	4/8 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910