DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttk and Btbd18

DIOPT Version :9

Sequence 1:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_002729248.1	Gene:	Btbd18 / 100363270	RGDID:	2323370	Length:	724	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	124/549 - (22%)
Similarity:	184/549 - (33%)	Gaps:	150/549 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 FDQLLHAE---TFTDVTLAVEGQHLKAHKMVLSACSPYF-NTLFVSHPEKHPIVILK--DVPYSD 81
            |.||.|.:   .|.|..|..||:.:.||..:||||||:| ..|....|.:...|:|:  .:....
  Rat    21 FLQLHHQQQSGVFCDALLQAEGEAVPAHCCILSACSPFFTERLERERPVQGRKVVLELGGLKIQT 85

  Fly    82 MKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGAGATGSESTATTPQ 146
            ::.|:||:|..|:.|.||.....|..|..||:                          |...|.|
  Rat    86 LRKLVDFLYTSEMEVSQEEAQDVLSAARQLRV--------------------------SELETLQ 124

  Fly   147 LQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKR---KRGRPRKLSGSSNG 208
            |:               ||.|..|..........:||.  |:|.:..|   .|.|||
  Rat   125 LE---------------GGKLVKAPQGRRLNRECLQPP--SAAPISARVVVPRSRPR-------- 164

  Fly   209 TGNDYDDFDRENMMNDSSDLGNGKMCNESYSGNDDGS--DDNQPNAGHTDD-----------LNE 260
                    ....:....|.||..|:   ...|.::|:  ..|.|||.:..|           |.:
  Rat   165 --------TPLPVTQTPSPLGAVKL---KSLGEEEGAHKKSNLPNADNLSDTLLLKKKARVCLTQ 218

  Fly   261 SRDSLPSKRSKNSKDHRVVSHHEDNSTSVTPTKATPELSQRLFGSS-STTISATAPGGSSTGPSE 324
            .|.|.||.:.:..|:::      .|..|.......|.:.::|.... ..:.|..:|...::.||.
  Rat   219 ERSSSPSSQREGPKENK------SNPGSTALPSLYPSVDEQLLPRKIRLSRSKPSPHVYTSKPSS 277

  Fly   325 TISLLEISDERESAPVHLPTILGLKIRAINTTTPAQQGSPQTPTKSKP---KIRQATGSNNSNSL 386
            .:          |.|..:||..|.::....|.:.|.||    ..|.||   ...|:|
  Rat   278 ML----------SGPSSMPTAPGRRLWRQRTVSEATQG----VDKQKPGEVSTLQST-------- 320

  Fly   387 LKQQLRGGAKDPEVPPATRITGAVTPNAALNAEEQSKEMPKKNQDEVNAC--IGLHSLANAAEQQ 449
                       |:.|...:..|...|:....|       |..|..|....  :.|..:.|....:
  Rat   321 -----------PDPPDVGKTGGKKQPSPESRA-------PASNSVEEGQVGRVKLRKIVNGTCWE 367

  Fly   450 AAQVASTGNLHH--QLLLHMAAN---NSMLNTTDYYQQQQQESPSSAGQFMDDDLELLSLND-QQ 508
            ..|.....|...  |:|....|:   .::|::.:     :||.|:.. |...|..|...|.| ..
  Rat   368 VVQEPPIRNTQDSPQILESSDADEPPGTLLSSVN-----EQEIPARI-QLCHDSPENSRLQDILL 426

  Fly   509 DKSDEPDHEMVTLADENAGLPGYQGNEAE 537
            ..|..|||.:|  ..|....|...|.|.|
  Rat   427 SASHSPDHPVV--KSEFGSSPMLTGKEPE 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttk	NP_001189329.1	BTB	23..119	CDD:279045	34/101 (34%)
		BTB	34..119	CDD:197585	29/87 (33%)
		C2H2 Zn finger	612..638	CDD:275370
		zf-C2H2_4	646..669	CDD:290605
		C2H2 Zn finger	648..669	CDD:275370
Btbd18	XP_002729248.1	BTB	24..123	CDD:279045	33/124 (27%)
Btbd18	XP_002729248.1	BTB	35..123	CDD:197585	30/113 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10373
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910