DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTry and TMPRSS3

DIOPT Version :9

Sequence 1:	NP_476771.1	Gene:	alphaTry / 48316	FlyBaseID:	FBgn0003863	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_076927.1	Gene:	TMPRSS3 / 64699	HGNCID:	11877	Length:	454	Species:	Homo sapiens

Alignment Length:	265	Identity:	88/265 - (33%)
Similarity:	122/265 - (46%)	Gaps:	39/265 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VILLSAVVCALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSANIIVTA 69
            |:.|....|        |.......|||||:.:.:|.:|||.|||..|.|.||||:.:...|:||
Human   199 VVTLQCTAC--------GHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITA 255

  Fly    70 AHCLQSV---SASVLQVRAGSTYWSSGGVVA---------KVSSFKNHEGYNANTMVNDIAVIRL 122
            |||:..:   .:..:||          |:|:         .|.....|..|....:.||||:::|
Human   256 AHCVYDLYLPKSWTIQV----------GLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKL 310

  Fly   123 SSSLSFSSSIKAISL--ATYNPANGASAAVSGWGTQSSGSSSIPSQLQYVNVNIVSQSQCASSTY 185
            :..|:|:..|:.:.|  :..|..:|.....||||....|:......|.:..|.::|...|.....
Human   311 AGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDV 375

  Fly   186 GYGSQIRNTMICAA--ASGKDACQGDSGGPLVSG----GVLVGVVSWGYGCAYSNYPGVYADVAV 244
             ||..|..:|:||.  ..|.|:||||||||||..    ..|||..|:|.|||..|.||||..|..
Human   376 -YGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTS 439

  Fly   245 LRSWV 249
            ...|:
Human   440 FLDWI 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	83/238 (35%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:292133	4/18 (22%)
		Tryp_SPc	216..444	CDD:214473	83/238 (35%)
		Tryp_SPc	217..447	CDD:238113	83/239 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910