DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTry and PRSS56

DIOPT Version :9

Sequence 1:	NP_476771.1	Gene:	alphaTry / 48316	FlyBaseID:	FBgn0003863	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_001356777.1	Gene:	PRSS56 / 646960	HGNCID:	39433	Length:	604	Species:	Homo sapiens

Alignment Length:	251	Identity:	84/251 - (33%)
Similarity:	123/251 - (49%)	Gaps:	36/251 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSANIIVTAAHCLQSVSASVLQVRAGSTYWS-- 91
            ||||||||....::||.:.||..|...|||.:.:|:.::|||||.......:|        |:
Human   103 GRIVGGSAAPPGAWPWLVRLQLGGQPLCGGVLVAASWVLTAAHCFVGAPNELL--------WTVT 159

  Fly    92 ----SGGVVAK---VSSFKNHEGYNANTMVNDIAVIRLSSSLSFSSSIKAISL--ATYNPANGAS 147
                |.|..|:   |:....|..::..|..||:|:::|.:.:|...|.:.:.|  ....|..|.:
Human   160 LAEGSRGEQAEEVPVNRILPHPKFDPRTFHNDLALVQLWTPVSPGGSARPVCLPQEPQEPPAGTA 224

  Fly   148 AAVSGWGTQSSGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIR-NTMICAA--ASGKDACQGD 209
            .|::|||..........: ::...|.::|...|..:   .|..:| :||:||.  |.|.|:||||
Human   225 CAIAGWGALFEDGPEAEA-VREARVPLLSTDTCRRA---LGPGLRPSTMLCAGYLAGGVDSCQGD 285

  Fly   210 SGGPLVSG-------GVLVGVVSWGYGCAYSNYPGVYADVAVLRSWV---VSTANS 255
            |||||...       .||.||.|||.||.....||||..|||.:.|:   :|.|:|
Human   286 SGGPLTCSEPGPRPREVLFGVTSWGDGCGEPGKPGVYTRVAVFKDWLQEQMSAASS 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	79/239 (33%)
PRSS56	NP_001356777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..96
		Tryp_SPc	105..335	CDD:238113	79/241 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910