DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTry and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_476771.1	Gene:	alphaTry / 48316	FlyBaseID:	FBgn0003863	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	257	Identity:	81/257 - (31%)
Similarity:	127/257 - (49%)	Gaps:	27/257 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VILLSAVVCALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSANIIVTA 69
            ::.|..:.|......|         |:||....::.|:|||:|:|....|.|||||...:.::||
Human   188 LVSLHCLACGKSLKTP---------RVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTA 243

  Fly    70 AHCLQS-VSASVLQVRAGSTYWSS--GGVVAKVSSFKNHEGYNANTMVNDIAVIRLSSSLSFSSS 131
            |||.:. ......:|||||....|  ...|||:...:.:..|..:   ||||:::|...|:||.:
Human   244 AHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKD---NDIALMKLQFPLTFSGT 305

  Fly   132 IKAISLATYN----PANGASAAVSGWGTQSSGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIR 192
            ::.|.|..::    ||  ....:.|||........:...|...:|.::..::| ::...|..::.
Human   306 VRPICLPFFDEELTPA--TPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRC-NADDAYQGEVT 367

  Fly   193 NTMICAA--ASGKDACQGDSGGPLV---SGGVLVGVVSWGYGCAYSNYPGVYADVAVLRSWV 249
            ..|:||.  ..|.|.|||||||||:   ....:||:|||||||...:.||||..|:...:|:
Human   368 EKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	77/230 (33%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	1/8 (13%)
		Tryp_SPc	204..429	CDD:214473	77/230 (33%)
		Tryp_SPc	205..432	CDD:238113	77/231 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910