DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaTry and Prss53

DIOPT Version :9

Sequence 1:	NP_476771.1	Gene:	alphaTry / 48316	FlyBaseID:	FBgn0003863	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	XP_006230384.1	Gene:	Prss53 / 499270	RGDID:	1566127	Length:	591	Species:	Rattus norvegicus

Alignment Length:	303	Identity:	73/303 - (24%)
Similarity:	129/303 - (42%)	Gaps:	67/303 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IVIL--LSAVVCALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSANII 66
            ::::  |.|...|.|...|....|| :|..:.|      .:|||.|::|.|.|.|.||:.:...:
  Rat    15 VIVIEGLQAAQRACGQRGPGPPEPQ-EGNTLPG------EWPWQASVRRQGVHICSGSLVADTWV 72

  Fly    67 VTAAHCLQSVSASVL---QVRAGSTY---WSSGGVVAKVSSFKNHEGYNANTMVNDIAVIRLSSS 125
            :|||||.:.::.:.|   .|..||..   .|.|.....|::.:..:.||..:..:|:|:::|:..
  Rat    73 LTAAHCFEKMATAELSSWSVVLGSLKQEGLSPGAEEVGVAALQLPKAYNHYSQGSDLALLQLTHP 137

  Fly   126 LSFSSSIKAISLATYNPANGASAAVSGWGTQSSGSSSIP------SQ------------------ 166
            :..::  ..:...|::...|||...:||...:|.....|      ||
  Rat   138 IVHTT--LCLPQPTHHFPFGASCWATGWDQNTSDGKYCPRHKSRESQTGSVLTVLALCSHCVSEL 200

  Fly   167 ------------LQYVNVNIVSQSQCASSTYG------YGSQIRNTMICAAASG--KDACQGDSG 211
                        |:.:.:.::|:..| :..|.      ..:..|:.|:|..|..  :..||||||
  Rat   201 DSTLSPLPVSRTLRNLRLRLISRPTC-NCLYNRLHQRLLANPARSGMLCGGAQPGVQGPCQGDSG 264

  Fly   212 GPLV-----SGGVLVGVVSWGYGCAYSNYPGVYADVAVLRSWV 249
            ||::     ...|.||::|:...||..:.|.:..|:|...||:
  Rat   265 GPVMCREPDGHWVQVGIISFTSNCAQEDTPVLLTDMAAHSSWL 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	64/273 (23%)
Prss53	XP_006230384.1	Tryp_SPc	45..310	CDD:238113	65/272 (24%)
Prss53	XP_006230384.1	Tryp_SPc	341..561	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343319
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.030