DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTry and CTRB2

DIOPT Version :9

Sequence 1:	NP_476771.1	Gene:	alphaTry / 48316	FlyBaseID:	FBgn0003863	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_001020371.3	Gene:	CTRB2 / 440387	HGNCID:	2522	Length:	263	Species:	Homo sapiens

Alignment Length:	266	Identity:	102/266 - (38%)
Similarity:	143/266 - (53%)	Gaps:	38/266 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ALGGT-----VPEGLLPQLDG--RIVGGSATTISSFPWQISLQ-RSGSHSCGGSIYSANIIVTAA 70
            ||.||     || .:.|.|.|  |||.|......|:|||:||| ::|.|.||||:.|.:.:||||
Human    11 ALLGTTFGCGVP-AIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAA 74

  Fly    71 HCLQSVSASVLQVRAGSTYWSSGG--------VVAKVSSFKNHEGYNANTMVNDIAVIRLSSSLS 127
            ||....|..|:   ||.  :..|.        .:|||  |||.: ::..|:.|||.:::|::...
Human    75 HCGVRTSDVVV---AGE--FDQGSDEENIQVLKIAKV--FKNPK-FSILTVNNDITLLKLATPAR 131

  Fly   128 FSSSIKAISLATYN---PANGASAAVSGWGTQSSGSSSIPSQLQYVNVNIVSQSQCASSTYGYGS 189
            ||.::.|:.|.:.:   || |...|.:|||.....::..|.:||...:.::|.::|..|   :|.
Human   132 FSQTVSAVCLPSADDDFPA-GTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKS---WGR 192

  Fly   190 QIRNTMICAAASGKDACQGDSGGPLV----SGGVLVGVVSWGYGCAYSNYPGVYADVAVLRSWV- 249
            :|.:.||||.|||..:|.||||||||    ....|||:||||.....:..|.|||.||.|..||
Human   193 RITDVMICAGASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSRTCSTTTPAVYARVAKLIPWVQ 257

  Fly   250 -VSTAN 254
             :..||
Human   258 KILAAN 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	89/234 (38%)
CTRB2	NP_001020371.3	Tryp_SPc	33..256	CDD:214473	89/234 (38%)
CTRB2	NP_001020371.3	Tryp_SPc	34..259	CDD:238113	90/236 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910