DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTry and OVCH1

DIOPT Version :9

Sequence 1:	NP_476771.1	Gene:	alphaTry / 48316	FlyBaseID:	FBgn0003863	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	XP_024304736.1	Gene:	OVCH1 / 341350	HGNCID:	23080	Length:	1120	Species:	Homo sapiens

Alignment Length:	258	Identity:	92/258 - (35%)
Similarity:	134/258 - (51%)	Gaps:	20/258 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VCALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSANIIVTAAHCLQ-- 74
            ||.:....|:    .|..||.||.......:|||:.|:..|.:.|||:|.:...|:|||||:|
Human   595 VCGIPPFSPQ----WLSRRIAGGEEACPHCWPWQVGLRFLGDYQCGGAIINPVWILTAAHCVQLK 655

  Fly    75 --SVSASVLQVRAGSTYWSSGGVVAKVSSFKNHEGYNANTMVNDIAVIRLSSSLSFSSSIKAISL 137
              .:|.:::..........|...|.:......||.:|..:..:|||:|:|||.|.::|.::.:.|
Human   656 NNPLSWTIIAGDHDRNLKESTEQVRRAKHIIVHEDFNTLSYDSDIALIQLSSPLEYNSVVRPVCL 720

  Fly   138 A-TYNPA-NGASAAVSGWGTQSSGSSSIPSQLQYVNVNIVSQSQCASSTY-GYGSQIRNTMICA- 198
            . :..|. :....||:|||: .|....:.|:||.:.|:::.:..|..:.| .:...|...||||
Human   721 PHSAEPLFSSEICAVTGWGS-ISADGGLASRLQQIQVHVLEREVCEHTYYSAHPGGITEKMICAG 784

  Fly   199 -AASG-KDACQGDSGGPLV---SGG--VLVGVVSWGYGCAYSNYPGVYADVAVLRSWVVSTAN 254
             |||| ||.||||||||||   ..|  ||.|:||||.||.....|||:|.|.:...|:.|..|
Human   785 FAASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLDWIQSKIN 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	85/233 (36%)
OVCH1	XP_024304736.1	Tryp_SPc	58..294	CDD:238113
		CUB	336..444	CDD:238001
		CUB	454..565	CDD:238001
		Tryp_SPc	610..845	CDD:238113	85/235 (36%)
		CUB	881..978	CDD:238001
		CUB	1017..1119	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910