DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTry and OVCH2

DIOPT Version :9

Sequence 1:	NP_476771.1	Gene:	alphaTry / 48316	FlyBaseID:	FBgn0003863	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	XP_016873148.1	Gene:	OVCH2 / 341277	HGNCID:	29970	Length:	569	Species:	Homo sapiens

Alignment Length:	299	Identity:	85/299 - (28%)
Similarity:	133/299 - (44%)	Gaps:	50/299 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KIVILLSAVVCALGGTVPEGLLPQ------------------LDGRIVGGSATTISSFPWQISLQ 49
            |:::||..|....|.:.... ||:                  :..||:|||.....|:|||:||:
Human    11 KLILLLGIVFFERGKSATLS-LPKAPSCGQSLVKVQPWNYFNIFSRILGGSQVEKGSYPWQVSLK 74

  Fly    50 RSGSHSCGGSIYSANIIVTAAHCLQSVS-ASVLQVRAGS---TYWSSGGVVAKVSSFKNHEGYNA 110
            :...|.|||||.|...::|||||:.:.: .|.|.|.||.   :....|.....:.:...|..::.
Human    75 QRQKHICGGSIVSPQWVITAAHCIANRNIVSTLNVTAGEYDLSQTDPGEQTLTIETVIIHPHFST 139

  Fly   111 -NTMVNDIAVIRLSSSLSFSSSIKAISLATYNP--ANGASAAVSGWGTQSSGSSSIPSQ-LQYVN 171
             ..|..|||:::::.:..|...:..|.|.....  ..|.....:|||..:.|  .:.|| ||.||
Human   140 KKPMDYDIALLKMAGAFQFGHFVGPICLPELREQFEAGFICTTAGWGRLTEG--GVLSQVLQEVN 202

  Fly   172 VNIVSQSQCASSTYGYGSQIR-NTMICAA--ASGKDACQGDSGGPLV-----SGGVLVGVVSWGY 228
            :.|::..:|.::.......|. .|.:|..  ..|:|||||||||.|:     ....|.||.|||.
Human   203 LPILTWEECVAALLTLKRPISGKTFLCTGFPDGGRDACQGDSGGSLMCRNKKGAWTLAGVTSWGL 267

  Fly   229 GC----------AYSNYPGVYADVAVLRSWV---VSTAN 254
            ||          :....||::.|::.:..|:   :.|.|
Human   268 GCGRGWRNNVRKSDQGSPGIFTDISKVLPWIHEHIQTGN 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	75/244 (31%)
OVCH2	XP_016873148.1	Tryp_SPc	55..298	CDD:214473	75/244 (31%)
		Tryp_SPc	56..301	CDD:238113	75/246 (30%)
		CUB	320..424	CDD:238001
		CUB	435..546	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910